ZFIN Morpholino: MO2-musk

Target Location

Genome Build: GRCz11Chromosome: 10

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-musk

Expressed Gene	Anatomy	Figures
chrna1	myotome acetylcholine-gated channel complex	Fig. 6 from Müller et al., 2010 Fig. 1 from Jing et al., 2009

Phenotype

Phenotype resulting from MO2-musk

Phenotype	Fish	Figures
myotome neuromuscular junction decreased amount, abnormal	WT + MO2-musk	Fig. 6 from Müller et al., 2010
neuromuscular junction development decreased occurrence, abnormal	WT + MO2-musk	Fig. 6 from Müller et al., 2010
skeletal muscle acetylcholine-gated channel clustering decreased occurrence, abnormal	WT + MO2-musk	Fig. 6 from Müller et al., 2010

Phenotype of all Fish created by or utilizing MO2-musk

Phenotype	Fish	Conditions	Figures
neuromuscular junction development decreased occurrence, abnormal	WT + MO2-musk	standard conditions	Fig. 6 from Müller et al., 2010
myotome neuromuscular junction decreased amount, abnormal	WT + MO2-musk	standard conditions	Fig. 6 from Müller et al., 2010
skeletal muscle acetylcholine-gated channel clustering decreased occurrence, abnormal	WT + MO2-musk	standard conditions	Fig. 6 from Müller et al., 2010
motor neuron axon branchiness, abnormal	slc24a5^b1/+ + MO2-musk	standard conditions	Fig. 3 from McMacken et al., 2018
myotome cholinergic synapse decreased amount, abnormal	slc24a5^b1/+ + MO2-musk	standard conditions	Fig. 3 from McMacken et al., 2018
motor neuron axon morphology, ameliorated	slc24a5^b1/+ + MO2-musk	chemical treatment by environment: forskolin	Fig. 5 from McMacken et al., 2018
motor neuron axon truncated, abnormal	slc24a5^b1/+ + MO2-musk	standard conditions	Fig. 3 from McMacken et al., 2018
motor neuron axon morphology, ameliorated	slc24a5^b1/+ + MO2-musk	chemical treatment by environment: albuterol	Fig. 3 from McMacken et al., 2018
motor neuron axon truncated, abnormal	slc24a5^b1/+ + MO2-musk	chemical treatment by environment: ICI 118551, chemical treatment by environment: albuterol	Fig. 4 from McMacken et al., 2018
myotome cholinergic synapse amount, ameliorated	slc24a5^b1/+ + MO2-musk	chemical treatment by environment: albuterol	Fig. 3 from McMacken et al., 2018
motor neuron axon branchiness, abnormal	slc24a5^b1/+ + MO2-musk	chemical treatment by environment: ICI 118551, chemical treatment by environment: albuterol	Fig. 4 from McMacken et al., 2018

Citations

Include unpublished citations

McMacken, G., Cox, D., Roos, A., Müller, J., Whittaker, R., Lochmüller, H. (2018) The Beta-Adrenergic Agonist Salbutamol Modulates Neuromuscular Junction Formation in Zebrafish Models of Human Myasthenic Syndromes. Human molecular genetics. 27(9):1556-1564
Müller, J.S., Jepson, C.D., Laval, S.H., Bushby, K., Straub, V., and Lochmüller, H. (2010) Dok-7 promotes slow muscle integrity as well as neuromuscular junction formation in a zebrafish model of congenital myasthenic syndromes. Human molecular genetics. 19(9):1726-1740
Jing, L., Lefebvre, J.L., Gordon, L.R., and Granato, M. (2009) Wnt signals organize synaptic prepattern and axon guidance through the zebrafish unplugged/MuSK receptor. Neuron. 61(5):721-733
Zhang, J., Lefebvre, J.L., Zhao, S., and Granato, M. (2004) Zebrafish unplugged reveals a role for muscle-specific kinase homologs in axonal pathway choice. Nature Neuroscience. 7(12):1303-1309

1 - 4 of 4

Show