ZFIN Morpholino: MO1-bmpr1aa

Target Location

Genome Build: GRCz11Chromosome: 13

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-bmpr1aa

No data available

Phenotype

Phenotype resulting from MO1-bmpr1aa

No data available

Phenotype of all Fish created by or utilizing MO1-bmpr1aa

Phenotype	Fish	Conditions	Figures
whole organism wholly dorsalized, abnormal	WT + MO1-bmpr1aa + MO1-bmpr1ab + MO2-bmpr1ab	standard conditions	Fig. 1 from Little et al., 2009
whole organism dorsalized, abnormal	WT + MO1-bmpr1aa + MO1-bmpr1ab + MO2-bmpr1ab + MO4-tp53	standard conditions	Fig. 3 from Demal et al., 2019
posterior cardinal vein ephb4a expression decreased amount, abnormal	WT + MO1-bmpr1aa + MO2-bmpr1ab	control	Fig. S14 from Neal et al., 2019
whole organism wholly dorsalized, abnormal	WT + MO1-bmpr1aa + MO1-bmpr1ab + MO1-bmpr1ba + MO2-bmpr1ab	standard conditions	Fig. 1 from Little et al., 2009
whole organism wholly dorsalized, abnormal	WT + MO1-bmpr1aa + MO1-bmpr1ab + MO1-bmpr1bb + MO2-bmpr1ab	standard conditions	Fig. 1 from Little et al., 2009

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Citations

Include unpublished citations

Tajer, B., Dutko, J.A., Little, S.C., Mullins, M.C. (2021) BMP heterodimers signal via distinct type I receptor class functions. Proceedings of the National Academy of Sciences of the United States of America. 118(15):
Demal, T.J., Heise, M., Reiz, B., Dogra, D., Brænne, I., Reichenspurner, H., Männer, J., Aherrahrou, Z., Schunkert, H., Erdmann, J., Abdelilah-Seyfried, S. (2019) A familial congenital heart disease with a possible multigenic origin involving a mutation in BMPR1A. Scientific Reports. 9:2959
Neal, A., Nornes, S., Payne, S., Wallace, M.D., Fritzsche, M., Louphrasitthiphol, P., Wilkinson, R.N., Chouliaras, K.M., Liu, K., Plant, K., Sholapurkar, R., Ratnayaka, I., Herzog, W., Bond, G., Chico, T., Bou-Gharios, G., De Val, S. (2019) Venous identity requires BMP signalling through ALK3. Nature communications. 10:453
Kim, J.D., Kim, J. (2014) Alk3/Alk3b and Smad5 Mediate BMP Signaling during Lymphatic Development in Zebrafish. Molecules and cells. 37:270-4
Neumann, J.C., Chandler, G.L., Damoulis, V.A., Fustino, N.J., Lillard, K., Looijenga, L., Margraf, L., Rakheja, D., and Amatruda, J.F. (2011) Mutation in the type IB bone morphogenetic protein receptor alk6b impairs germ-cell differentiation and causes germ-cell tumors in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(32):13153-8
Little, S.C., and Mullins, M.C. (2009) Bone morphogenetic protein heterodimers assemble heteromeric type I receptor complexes to pattern the dorsoventral axis. Nature cell biology. 11(5):637-643

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