ZFIN Morpholino: MO1-egfl7

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-egfl7

No data available

Phenotype

Phenotype resulting from MO1-egfl7

Phenotype	Fish	Figures
axial vasculature decreased area, abnormal	s843Tg + MO1-egfl7	Fig. 5 from De Mazière et al., 2008
blood vessel endothelial cell mislocalised, abnormal	WT + MO1-egfl7	Fig. 1 from Schmidt et al., 2007
blood vessel endothelial cell bicellular tight junction increased amount, abnormal	s843Tg + MO1-egfl7	Fig. 6 , Fig. 7 from De Mazière et al., 2008
blood vessel endothelial cell bicellular tight junction mislocalised, abnormal	s843Tg + MO1-egfl7	Fig. 6 , Fig. 7 from De Mazière et al., 2008
blood vessel endothelial cell migration disrupted, abnormal	WT + MO1-egfl7	Fig. 1 from Schmidt et al., 2007

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Phenotype of all Fish created by or utilizing MO1-egfl7

Phenotype	Fish	Conditions	Figures
whole organism casp8 expression increased amount, abnormal	AB + MO1-egfl7	standard conditions	Fig. 4 from Lai et al., 2019
whole organism isg20 expression increased amount, abnormal	AB + MO1-egfl7	standard conditions	Fig. 4 from Lai et al., 2019
whole organism phlda3 expression increased amount, abnormal	AB + MO1-egfl7	standard conditions	Fig. 4 from Lai et al., 2019
whole organism tp53 expression increased amount, abnormal	AB + MO1-egfl7	standard conditions	Fig. 4 from Lai et al., 2019
cellular response to stress increased process quality, abnormal	AB + MO1-egfl7	standard conditions	Fig. 4 from Lai et al., 2019

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Citations

Include unpublished citations

Jin, S., Na, H., Jeon, H., Park, J., Choe, C.P. (2021) egfl6 expression in the pharyngeal pouch is dispensable for craniofacial development. Animal cells and systems. 25:255-263
Lai, J.K.H., Gagalova, K.K., Kuenne, C., El-Brolosy, M.A., Stainier, D.Y.R. (2019) Induction of interferon-stimulated genes and cellular stress pathways by morpholinos in zebrafish. Developmental Biology. 454(1):21-28
Renz, M., Otten, C., Faurobert, E., Rudolph, F., Zhu, Y., Boulday, G., Duchene, J., Mickoleit, M., Dietrich, A.C., Ramspacher, C., Steed, E., Manet-Dupé, S., Benz, A., Hassel, D., Vermot, J., Huisken, J., Tournier-Lasserve, E., Felbor, U., Sure, U., Albiges-Rizo, C., Abdelilah-Seyfried, S. (2015) Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins. Developmental Cell. 32:181-190
Rossi, A., Kontarakis, Z., Gerri, C., Nolte, H., Hölper, S., Krüger, M., Stainier, D.Y. (2015) Genetic compensation induced by deleterious mutations but not gene knockdowns. Nature. 524(7564):230-3
De Mazière, A., Parker, L., Van Dijk, S., Ye, W., and Klumperman, J. (2008) Egfl7 knockdown causes defects in the extension and junctional arrangements of endothelial cells during zebrafish vasculogenesis. Developmental Dynamics : an official publication of the American Association of Anatomists. 237(3):580-591
Schmidt, M., De Mazière, A., Smyczek, T., Gray, A., Parker, L., Filvaroff, E., French, D., van Dijk, S., Klumperman, J., and Ye, W. (2007) The role of Egfl7 in vascular morphogenesis. Novartis Foundation symposium. 283(1):18-28
Parker, L.H., Schmidt, M., Jin, S.W., Gray, A.M., Beis, D., Pham, T., Frantz, G., Palmieri, S., Hillan, K., Stainier, D.Y., De Sauvage, F.J., Ye, W. (2004) The endothelial-cell-derived secreted factor Egfl7 regulates vascular tube formation. Nature. 425(6984):754-758

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