ZFIN Morpholino: MO1-amot

Target Location

Genome Build: GRCz11Chromosome: 21

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-amot

No data available

Phenotype

Phenotype resulting from MO1-amot

Phenotype	Fish	Figures
angiogenesis disrupted, abnormal	y1Tg + MO1-amot	Fig. 7 from Ernkvist et al., 2009
blood vessel endothelial cell migration disrupted, abnormal	y1Tg + MO1-amot	Fig. 1 from Ernkvist et al., 2009 Fig. 1 from Aase et al., 2007
cell migration involved in sprouting angiogenesis arrested, abnormal	y1Tg + MO1-amot	Fig. 1 from Aase et al., 2007
dorsal longitudinal anastomotic vessel aplastic, abnormal	y1Tg + MO1-amot	Fig. 1 from Aase et al., 2007
endothelial tip cell filopodium decreased amount, abnormal	y1Tg + MO1-amot	Fig. 1 from Aase et al., 2007

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Phenotype of all Fish created by or utilizing MO1-amot

Phenotype	Fish	Conditions	Figures
cell migration involved in sprouting angiogenesis arrested, abnormal	y1Tg + MO1-amot	standard conditions	Fig. 1 from Aase et al., 2007
intersegmental vessel morphology, abnormal	y1Tg + MO1-amot	standard conditions	Fig. 7 from Ernkvist et al., 2009
intersegmental vessel decreased length, abnormal	y1Tg + MO1-amot	standard conditions	Fig. 6 from Zheng et al., 2009
angiogenesis disrupted, abnormal	y1Tg + MO1-amot	standard conditions	Fig. 7 from Ernkvist et al., 2009
primordial hindbrain channel dilated, abnormal	y1Tg + MO1-amot	standard conditions	Fig. 1 from Aase et al., 2007

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Citations

Include unpublished citations

Dai, X., She, P., Chi, F., Feng, Y., Liu, H., Jin, D., Zhao, Y., Guo, X., Jiang, D., Guan, K.L., Zhong, T.P., and Zhao, B. (2013) Phosphorylation of angiomotin by Lats1/2 kinases inhibits F-actin binding, cell migration and angiogenesis. The Journal of biological chemistry. 288(47):34041-51
Li, Z., Wang, Y., Zhang, M., Xu, P., Huang, H., Wu, D., and Meng, A. (2012) Amotl2 gene inhibits Wnt/beta-catenin signaling and regulates embryonic development in zebrafish embryoys. The Journal of biological chemistry. 287(16):13005-13015
Ernkvist, M., Luna Persson, N., Audebert, S., Lecine, P., Sinha, I., Liu, M., Schlueter, M., Horowitz, A., Aase, K., Weide, T., Borg, J.P., Majumdar, A., and Holmgren, L. (2009) The Amot/Patj/Syx signaling complex spatially controls RhoA GTPase activity in migrating endothelial cells. Blood. 113(1):244-253
Zheng, Y., Vertuani, S., Nyström, S., Audebert, S., Meijer, I., Tegnebratt, T., Borg, J.P., Uhlén, P., Majumdar, A., and Holmgren, L. (2009) Angiomotin-Like Protein 1 Controls Endothelial Polarity and Junction Stability During Sprouting Angiogenesis. Circulation research. 105(3):260-270
Aase, K., Ernkvist, M., Ebarasi, L., Jakobsson, L., Majumdar, A., Yi, C., Birot, O., Ming, Y., Kvanta, A., Edholm, D., Aspenström, P., Kissil, J., Claesson-Welsh, L., Shimono, A., and Holmgren, L. (2007) Angiomotin regulates endothelial cell migration during embryonic angiogenesis. Genes & Development. 21(16):2055-2068

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