ZFIN Morpholino: MO1-mtor

Target Location

Genome Build: GRCz11Chromosome: 8

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-mtor

Expressed Gene	Anatomy	Figures
fabp2	gut	Fig. 7 from Makky et al., 2007
fabp10a	liver	Fig. 4 from Wang et al., 2018
urb1	digestive system	Fig. 5 from He et al., 2017

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Phenotype

Phenotype resulting from MO1-mtor

Phenotype	Fish	Figures
digestive system urb1 expression decreased amount, abnormal	s854Tg + MO1-mtor	Fig. 5 from He et al., 2017
gut decreased size, abnormal	WT + MO1-mtor	Fig. 7 from Makky et al., 2007
gut endothelial cell morphology, abnormal	WT + MO1-mtor	Fig. 7 from Makky et al., 2007
gut epithelium morphology, abnormal	WT + MO1-mtor	Fig. 7 from Makky et al., 2007
intestine decreased size, abnormal	WT + MO1-mtor	Fig. 7 from Makky et al., 2007

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Phenotype of all Fish created by or utilizing MO1-mtor

Phenotype	Fish	Conditions	Figures
gut decreased size, abnormal	WT + MO1-mtor	standard conditions	Fig. 7 from Makky et al., 2007
gut epithelium morphology, abnormal	WT + MO1-mtor	standard conditions	Fig. 7 from Makky et al., 2007
intestine decreased size, abnormal	WT + MO1-mtor	standard conditions	Fig. 7 from Makky et al., 2007
liver decreased size, abnormal	WT + MO1-mtor	standard conditions	Fig. 7 from Makky et al., 2007
gut endothelial cell morphology, abnormal	WT + MO1-mtor	standard conditions	Fig. 7 from Makky et al., 2007

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Citations

Include unpublished citations

Sun, X., Zhou, Y., Zhang, R., Wang, Z., Xu, M., Zhang, D., Huang, J., Luo, F., Li, F., Ni, Z., Zhou, S., Chen, H., Chen, S., Chen, L., Du, X., Chen, B., Huang, H., Liu, P., Yin, L., Qiu, J., Chen, D., Deng, C., Xie, Y., Luo, L., Chen, L. (2020) Dstyk mutation leads to congenital scoliosis-like vertebral malformations in zebrafish via dysregulated mTORC1/TFEB pathway. Nature communications. 11:479
Chaturantabut, S., Shwartz, A., Evason, K.J., Cox, A.G., Labella, K., Schepers, A.G., Yang, S., Aravena, M., Houvras, Y., Mancio-Silva, L., Romano, S., Gorelick, D.A., Cohen, D.E., Zon, L.I., Bhatia, S.N., North, T.E., Goessling, W. (2019) Estrogen Activation of G protein-coupled Estrogen Receptor 1 Regulates Phosphoinositide 3-kinase and mTOR Signaling to Promote Liver Growth in Zebrafish and Proliferation of Human Hepatocytes. Gastroenterology. 156(6):1788-1804.e13
Wang, Z., Song, J., Luo, L., Ma, J. (2018) Loss of Leucyl-tRNA synthetase b leads to ILFS1-like symptoms in zebrafish. Biochemical and Biophysical Research Communications. 505(2):378-384
Zhang, Y.M., Zimmer, M.A., Guardia, T., Callahan, S.J., Mondal, C., Di Martino, J., Takagi, T., Fennell, M., Garippa, R., Campbell, N.R., Bravo-Cordero, J.J., White, R.M. (2018) Distant Insulin Signaling Regulates Vertebrate Pigmentation through the Sheddase Bace2. Developmental Cell. 45(5):580-594.e7
He, J., Yang, Y., Zhang, J., Chen, J., Wei, X., He, J., Luo, L. (2017) Ribosome biogenesis protein Urb1 acts downstream of mTOR complex 1 to modulate digestive organ development in zebrafish. Journal of genetics and genomics = Yi chuan xue bao. 44(12):567-576
Chu, C.Y., Chen, C.F., Rajendran, R.S., Shen, C.N., Chen, T.H., Yen, C.C., Chuang, C.K., Lin, D.S., and Hsiao, C.D. (2012) Overexpression of akt1 enhances adipogenesis and leads to lipoma formation in zebrafish. PLoS One. 7(5):e36474
Makky, K., Tekiela, J., and Mayer, A.N. (2007) Target of rapamycin (TOR) signaling controls epithelial morphogenesis in the vertebrate intestine. Developmental Biology. 303(2):501-513

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