ZFIN Morpholino: MO2-krit1

Target Location

Genome Build: GRCz11Chromosome: 19

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO2-krit1

No data available

Phenotype

Phenotype resulting from MO2-krit1

Phenotype	Fish	Figures
heart dilated, abnormal	s843Tg + MO2-krit1	Fig. 5 from Gingras et al., 2012 Fig. 5 from Liu et al., 2011
thymus decreased size, abnormal	WT + MO2-krit1	Fig. 3 from Wang et al., 2011
thymus hematopoietic multipotent progenitor cell decreased amount, abnormal	WT + MO2-krit1	Fig. 3 from Wang et al., 2011
trunk hematopoietic multipotent progenitor cell decreased amount, abnormal	WT + MO2-krit1	Fig. 3 from Wang et al., 2011

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Phenotype of all Fish created by or utilizing MO2-krit1

Phenotype	Fish	Conditions	Figures
trunk hematopoietic multipotent progenitor cell decreased amount, abnormal	WT + MO2-krit1	standard conditions	Fig. 3 from Wang et al., 2011
thymus hematopoietic multipotent progenitor cell decreased amount, abnormal	WT + MO2-krit1	standard conditions	Fig. 3 from Wang et al., 2011
thymus decreased size, abnormal	WT + MO2-krit1	standard conditions	Fig. 3 from Wang et al., 2011
heart dilated, abnormal	s843Tg + MO2-krit1	standard conditions	Fig. 5 from Gingras et al., 2012 Fig. 5 from Liu et al., 2011
vascular endothelium apoptotic, abnormal	y1Tg + MO1-krit1 + MO2-krit1 (AB)	standard conditions	Fig. 4, Fig. 5 from Liu et al., 2010

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Citations

Include unpublished citations

Gingras, A.R., Liu, J.J., and Ginsberg, M.H. (2012) Structural basis of the junctional anchorage of the cerebral cavernous malformations complex. The Journal of cell biology. 199(1):39-48
Liu, H., Rigamonti, D., Badr, A., and Zhang, J. (2011) Ccm1 Regulates Microvascular Morphogenesis during Angiogenesis. Journal of vascular research. 48(2):130-140
Liu, J.J., Stockton, R.A., Gingras, A.R., Ablooglu, A.J., Han, J., Bobkov, A.A., Ginsberg, M.H. (2011) A mechanism of Rap1-induced stabilization of endothelial cell--cell junctions. Molecular biology of the cell. 22:2509-19
Wang, L., Zhang, P., Wei, Y., Gao, Y., Patient, R., and Liu, F. (2011) A blood flow-dependent klf2a-NO signalling cascade is required for stabilization of hematopoietic stem cell programming in zebrafish embryos. Blood. 118(15):4102-10
Liu, H., Rigamonti, D., Badr, A., and Zhang, J. (2010) Ccm1 Assures Microvascular Integrity During Angiogenesis. Translational Stroke Research. 1(2):146-153
Mably, J.D., Chuang, L.P., Serluca, F.C., Mohideen, M.A., Chen, J.N., and Fishman, M.C. (2006) santa and valentine pattern concentric growth of cardiac myocardium in the zebrafish. Development (Cambridge, England). 133(16):3139-3146

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