ZFIN Morpholino: MO1-bbs7

Target Location

Genome Build: GRCz11Chromosome: 14

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-bbs7

No data available

Phenotype

Phenotype resulting from MO1-bbs7

Phenotype	Fish	Figures
convergent extension process quality, abnormal	WT + MO1-bbs7	Fig. 5 from Lindstrand et al., 2014
embryonic pattern specification disrupted, abnormal	WT + MO1-bbs7	Fig. 4 from Tayeh et al., 2008
embryonic pectoral fin morphogenesis disrupted, abnormal	WT + MO1-bbs7	Fig. 4 from Tayeh et al., 2008
eye decreased size, abnormal	WT + MO1-bbs7	Fig. 2 from Putoux et al., 2011
gastrulation disrupted, abnormal	WT + MO1-bbs7	Fig. S4 from Zaghloul et al., 2010

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Phenotype of all Fish created by or utilizing MO1-bbs7

Phenotype	Fish	Conditions	Figures
notochord increased width, abnormal	WT + MO1-bbs7	standard conditions	Fig. 5 from Lindstrand et al., 2014
scapulocoracoid morphology, abnormal	WT + MO1-bbs7	standard conditions	Fig. 5 from Tayeh et al., 2008
scapulocoracoid increased size, abnormal	WT + MO1-bbs7	standard conditions	Fig. 5 from Tayeh et al., 2008
somite increased width, abnormal	WT + MO1-bbs7	standard conditions	Fig. 5 from Lindstrand et al., 2014 Fig. 2 from Putoux et al., 2011 Fig. S4 from Zaghloul et al., 2010
pronephric proximal convoluted tubule morphology, abnormal	WT + MO1-bbs7	standard conditions	Fig. 5 from Lindstrand et al., 2014

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Citations

Include unpublished citations

Lindstrand, A., Davis, E.E., Carvalho, C.M., Pehlivan, D., Willer, J.R., Tsai, I.C., Ramanathan, S., Zuppan, C., Sabo, A., Muzny, D., Gibbs, R., Liu, P., Lewis, R.A., Banin, E., Lupski, J.R., Clark, R., Katsanis, N. (2014) Recurrent CNVs and SNVs at the NPHP1 Locus Contribute Pathogenic Alleles to Bardet-Biedl Syndrome. American journal of human genetics. 94:745-54
Mei, X., Westfall, T.A., Zhang, Q., Sheffield, V.C., Bassuk, A.G., Slusarski, D.C. (2014) Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms. Developmental Biology. 392(2):245-55
Putoux, A., Thomas, S., Coene, K.L.M., Davis, E.E., Alanay, Y., Ogur, G., Uz, E., Buzas, D., Gomes, C., Patrier, S., Bennett, C.L., Elkhartoufi, N., Saint Frison, M.H., Rigonnot, L., Joye, N., Pruvost, S., Utine, G.E., Boduroglu, K., Nitschke, P., Fertitta, L., Thauvin-Robinet, C., Munnich, A., Cormier-Daire, V., Hennekam, R., Colin, E., Akarsu, N.A., Bole-Feysot, C., Cagnard, N., Schmitt, A., Goudin, N., Lyonnet, S., Encha-Razavi, F., Siffroi, J.P., Winey, M., Katsanis, N., Gonzales, M., Vekemans, M., Beales, P.L., and Attie-Bitach, T. (2011) KIF7 mutations cause fetal hydrolethalus and acrocallosal syndromes. Nature Genetics. 43:601-606
Zaghloul, N.A., Liu, Y., Gerdes, J.M., Gascue, C., Oh, E.C., Leitch, C.C., Bromberg, Y., Binkley, J., Leibel, R.L., Sidow, A., Badano, J.L., and Katsanis, N. (2010) Functional analyses of variants reveal a significant role for dominant negative and common alleles in oligogenic Bardet-Biedl syndrome. Proceedings of the National Academy of Sciences of the United States of America. 107(23):10602-10607
Tayeh, M.K., Yen, H.J., Beck, J.S., Searby, C.C., Westfall, T.A., Griesbach, H., Sheffield, V.C., and Slusarski, D.C. (2008) Genetic interaction between Bardet-Biedl syndrome genes and implications for limb patterning. Human molecular genetics. 17(13):1956-1967
Yen, H.J., Tayeh, M.K., Mullins, R.F., Stone, E.M., Sheffield, V.C., and Slusarski, D.C. (2006) Bardet-Biedl syndrome genes are important in retrograde intracellular trafficking and Kupffer's vesicle cilia function. Human molecular genetics. 15(5):667-677

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