ZFIN Morpholino: MO1-mcm5

Target Location

Genome Build: GRCz11Chromosome: 3

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-mcm5

No data available

Phenotype

Phenotype resulting from MO1-mcm5

Phenotype	Fish	Figures
apoptotic process increased occurrence, abnormal	AB + MO1-mcm5	Fig. 3 from Liu et al., 2009
embryo development disrupted, abnormal	AB + MO1-mcm5	Fig. 5 from Bicknell et al., 2011
eye decreased size, abnormal	AB + MO1-mcm5	Fig. 1 from Wu et al., 2021
fourth ventricle decreased size, abnormal	AB + MO1-mcm5	Fig. 1 from Wu et al., 2021
gastrulation with mouth forming second disrupted, abnormal	AB + MO1-mcm5	Fig. 1 from Liu et al., 2009

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Phenotype of all Fish created by or utilizing MO1-mcm5

Phenotype	Fish	Conditions	Figures
hindbrain etv4 expression decreased distribution, abnormal	AB + MO1-mcm5	control	Fig. 4 from Wu et al., 2021
hypoblast apoptotic, abnormal	AB + MO1-mcm5	standard conditions	Fig. 3 from Liu et al., 2009
rhombomere 6 cranial motor neuron increased amount, abnormal	AB + MO1-mcm5	standard conditions	Fig. 1 from Wu et al., 2021
eye decreased size, abnormal	AB + MO1-mcm5	control	Fig. 1 from Wu et al., 2021
fourth ventricle decreased size, abnormal	AB + MO1-mcm5	control	Fig. 1 from Wu et al., 2021

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Citations

Include unpublished citations

Liu, M., Li, Y., Deng, Z., Zhang, K., Huang, S., Xia, J., Feng, Y., Liang, Y., Sun, C., Liu, X., Li, S., Su, B., Dong, Y., Huang, S. (2025) Mcm5 mutation leads to silencing of Stat1-bcl2 which accelerating apoptosis of immature T lymphocytes with DNA damage. Cell Death & Disease. 16:8484
Wu, Y., Huang, S., Zhao, H., Cao, K., Gan, J., Yang, C., Xu, Z., Li, S., Su, B. (2021) Zebrafish Minichromosome Maintenance Protein 5 Gene Regulates the Development and Migration of Facial Motor Neurons via Fibroblast Growth Factor Signaling. Developmental neuroscience. 43(2):84-94
Bicknell, L.S., Walker, S., Klingseisen, A., Stiff, T., Leitch, A., Kerzendorfer, C., Martin, C.A., Yeyati, P., Al Sanna, N., Bober, M., Johnson, D., Wise, C., Jackson, A.P., O'Driscoll, M., and Jeggo, P.A. (2011) Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. Nature Genetics. 43(4):350-5
Liu, X., Huang, S., Ma, J., Li, C., Zhang, Y., and Luo, L. (2009) NF-kappaB and Snail1a coordinate the cell cycle with gastrulation. The Journal of cell biology. 184(6):805-815
Ryu, S., Holzschuh, J., Erhardt, S., Ettl, A.K., and Driever, W. (2005) Depletion of minichromosome maintenance protein 5 in the zebrafish retina causes cell-cycle defect and apoptosis. Proceedings of the National Academy of Sciences of the United States of America. 102(51):18467-18472

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