ZFIN Morpholino: MO1-mitfa

Target Location

Genome Build: GRCz11Chromosome: 6

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-mitfa

No data available

Phenotype

Phenotype resulting from MO1-mitfa

Phenotype	Fish	Figures
developmental pigmentation disrupted, abnormal	WT + MO1-mitfa	Fig. 2 from Lemeer et al., 2007
melanocyte absent, abnormal	WT + MO1-mitfa + MO4-tp53	Fig. 5 from Robu et al., 2007
melanocyte differentiation delayed, abnormal	WT + MO1-mitfa	Fig. 1 from Mellgren et al., 2004
melanocyte differentiation disrupted, abnormal	WT + MO1-mitfa	Fig. 1 from Mellgren et al., 2004
melanocyte migration disrupted, abnormal	WT + MO1-mitfa	Fig. 2 from Mellgren et al., 2004

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Phenotype of all Fish created by or utilizing MO1-mitfa

Phenotype	Fish	Conditions	Figures
developmental pigmentation disrupted, abnormal	WT + MO1-mitfa	standard conditions	Fig. 2 from Lemeer et al., 2007
melanocyte migration disrupted, abnormal	WT + MO1-mitfa	standard conditions	Fig. 2 from Mellgren et al., 2004
melanocyte differentiation delayed, abnormal	WT + MO1-mitfa	standard conditions	Fig. 1 from Mellgren et al., 2004
whole organism lacks parts or has fewer parts of type melanocyte, abnormal	WT + MO1-mitfa	standard conditions	Fig. 1 from Mellgren et al., 2004
whole organism lacks parts or has fewer parts of type melanoblast, abnormal	WT + MO1-mitfa	standard conditions	Fig. 2 from Mellgren et al., 2004

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Citations

Include unpublished citations

Müller-Deile, J., Schenk, H., Niggemann, P., Bolaños-Palmieri, P., Teng, B., Higgs, A., Staggs, L., Haller, H., Schroder, P., Schiffer, M. (2019) Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathy. Biology Open. 8(3):
Hammarström, L.G., Harmel, R.K., Granath, M., Ringom, R., Gravenfors, Y., Färnegårdh, K., Svensson, P.H., Wennman, D., Lundin, G., Roddis, Y., Kitambi, S.S., Bernlind, A., Lehmann, F., Ernfors, P. (2016) The Oncolytic Efficacy and in Vivo Pharmacokinetics of [2-(4-Chlorophenyl)quinolin-4-yl](piperidine-2-yl)methanol (Vacquinol-1) Are Governed by Distinct Stereochemical Features. Journal of medicinal chemistry. 59:8577-92
Paardekooper Overman, J., Preisinger, C., Prummel, K., Bonetti, M., Giansanti, P., Heck, A., Hertog, J.D. (2014) Phosphoproteomics-Mediated Identification of Fer Kinase as a Target of Mutant Shp2 in Noonan and LEOPARD Syndrome. PLoS One. 9:e106682
Paardekooper Overman, J., Yi, J.S., Bonetti, M., Soulsby, M., Preisinger, C., Stokes, M.P., Hui, L., Silva, J.C., Overvoorde, J., Giansanti, P., Heck, A.J., Kontaridis, M.I., den Hertog, J., Bennett, A.M. (2014) PZR Coordinates Shp2 Noonan and LEOPARD Syndrome Signaling in Zebrafish and Mice. Molecular and cellular biology. 34(15):2874-89
Helker, C.S., Schuermann, A., Karpanen, T., Zeuschner, D., Belting, H.G., Affolter, M., Schulte-Merker, S., and Herzog, W. (2013) The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment. Development (Cambridge, England). 140(13):2776-2786
Li, Y., Li, G., Wang, H., Du, J., and Yan, J. (2013) Analysis of a gene regulatory cascade mediating circadian rhythm in zebrafish. PLoS Computational Biology. 9(2):e1002940
Sundström, E., Komisarczuk, A.Z., Jiang, L., Golovko, A., Navratilova, P., Rinkwitz, S., Becker, T.S., and Andersson, L. (2012) Identification of a melanocyte-specific, microphthalmia-associated transcription factor-dependent regulatory element in the intronic duplication causing hair greying and melanoma in horses. Pigment cell & melanoma research. 25(1):28-36
Curran, K., Lister, J.A., Kunkel, G.R., Prendergast, A., Parichy, D.M., and Raible, D.W. (2010) Interplay between Foxd3 and Mitf regulates cell fate plasticity in the zebrafish neural crest. Developmental Biology. 344(1):107-118
Lemeer, S., Jopling, C., Naji, F., Ruijtenbeek, R., Slijper, M., Heck, A.J., and den Hertog, J. (2007) Protein-tyrosine kinase activity profiling in knock down zebrafish embryos. PLoS One. 2(1):e581
Robu, M.E., Larson, J.D., Nasevicius, A., Beiraghi, S., Brenner, C., Farber, S.A., and Ekker, S.C. (2007) p53 activation by knockdown technologies. PLoS Genetics. 3(5):e78

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