ZFIN Lab: Kane Lab

ZFIN ID: ZDB-LAB-990930-6

Kane Lab

PI/Director:	Kane, Donald A.
Co-PI / Senior Researcher:	Warga, Rachel M.
Contact Person:	Warga, Rachel M.
Email:	rachel.warga@wmich.edu
URL:	http://www.wmich.edu/bios/faculty/kane.html
Address:	Dept of Biological Sciences Western Michigan University Kalamazoo, MI 49008 USA
Country:	United States
Phone:	(296) 387-0781
Fax:	(296) 387-5609
Line Designation:	kw

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

The lab is interested in understanding the role of cell motility, cell contact and cell shape in the determination of cellular fate. The lab is additionally interested in the relationship of the cell cycle and early cell fate determination.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Petrachkova, T., Wortinger, L.A., Bard, A.J., Singh, J., Warga, R.M., Kane, D.A. (2019) Lack of Cyclin B1 in zebrafish causes lengthening of G2 and M phases. Developmental Biology. 451(2):167-179

Warga, R.M., Kane, D.A. (2018) Probing Cadherin Interactions in Zebrafish with E- and N-Cadherin Missense Mutants. Genetics. 210(4):1391-1409

Warga, R.M., Kane, D.A. (2018) A Wilson cell origin for Kupffer's vesicle in the zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 247(9):1057-1069

Warga, R.M., Wicklund, A., Richards, S.E., Kane, D.A. (2016) Progressive loss of RacGAP1/ogre activity has sequential effects on cytokinesis and zebrafish development. Developmental Biology. 418(2):307-22

Warga, R.M., Mueller, R.L., Ho, R.K., and Kane, D.A. (2013) Zebrafish Tbx16 regulates intermediate mesoderm cell fate by attenuating Fgf activity. Developmental Biology. 383(1):75-89

Riley, B.B., Sweet, E.M., Heck, R., Evans, A., McFarland, K.N., Warga, R.M., and Kane, D.A. (2010) Characterization of harpy/Rca1/emi1 mutants: patterning in the absence of cell division. Developmental Dynamics : an official publication of the American Association of Anatomists. 239(3):828-843

Warga, R.M., Kane, D.A., and Ho, R.K. (2009) Fate mapping embryonic blood in zebrafish: multi- and unipotential lineages are segregated at gastrulation. Developmental Cell. 16(5):744-755

Warga, R.M., and Kane, D.A. (2007) A role for N-cadherin in mesodermal morphogenesis during gastrulation. Developmental Biology. 310(2):211-225

Ward, A.B., Warga, R.M., and Prince, V.E. (2007) Origin of the zebrafish endocrine and exocrine pancreas. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(6):1558-1569

McFarland, K.N., Warga, R.M., and Kane, D.A. (2005) Genetic locus half baked is necessary for morphogenesis of the ectoderm. Developmental Dynamics : an official publication of the American Association of Anatomists. 233(2):390-406

Kane, D.A., McFarland, K.N., and Warga, R.M. (2005) Mutations in half baked/E-cadherin block cell behaviors that are necessary for teleost epiboly. Development (Cambridge, England). 132(5):1105-1116

Warga, R.M. and Kane, D.A. (2003) One-eyed pinhead regulates cell motility independent of Squint/Cyclops signaling. Developmental Biology. 261(2):391-411

Dougan, S.T., Warga, R.M., Kane, D.A., Schier, A.F., and Talbot, W.S. (2003) The role of the zebrafish nodal-related genes squint and cyclops in patterning of mesendoderm. Development (Cambridge, England). 130(9):1837-1851

Kane, D. and Adams, R. (2002) Life at the edge: epiboly and involution in the zebrafish. Results and problems in cell differentiation. 40:117-135

Warga, R.M. and Stainier, D.Y.R. (2002) The guts of endoderm formation. Results and problems in cell differentiation. 40:28-47

Warga, R.M. and Nüsslein-Volhard, C. (1999) Origin and development of the zebrafish endoderm. Development (Cambridge, England). 126:827-838

Kane, D.A. (1999) Cell cycles and development in the embryonic zebrafish. In The Zebrafish: Biology. H.W. Detrich, L.I. Zon, and M. Westerfield, eds. Methods Cell Biol.. 59:11-26

Kane, D.A., Zon, L.I., and Detrich, H.W., III (1999) Centromeric markers in the zebrafish. In The Zebrafish: Genetics and Genomics, H.W. Detrich, III, M. Westerfield, and L.I. Zon, eds., San Diego, CA: Academic Press, Methods Cell Biol.. 60:361-363

Warga, R.M. and Nüsslein-Volhard, C. (1998) Spadetail-dependent cell compaction of the dorsal zebrafish blastula. Developmental Biology. 203:116-121

Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Lun, K., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations in zebrafish genes affecting the formation of the boundary between midbrain and hindbrain. Development (Cambridge, England). 123:179-190

Brand, M., Heisenberg, C.P., Warga, R.M., Pelegri, F., Karlstrom, R.O., Beuchle, D., Picker, A., Jiang, Y.J., Furutani-Seiki, M., van Eeden, F.J., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the midline and general body shape during zebrafish embryogenesis. Development (Cambridge, England). 123:129-142

Chen, J.N., Haffter, P., Odenthal, J., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development (Cambridge, England). 123:293-302

Furutani-Seiki, M., Jiang, Y.J., Brand, M., Heisenberg, C.P., Houart, C., Beuchle, D., van Eeden, F.J.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Neural degeneration mutants in the zebrafish, Danio rerio. Development (Cambridge, England). 123:229-239

Granato, M., van Eeden, F.J., Schach, U., Trowe, T., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes controlling and mediating locomotion behavior of the zebrafish embryo and larva. Development (Cambridge, England). 123:399-413

Haffter, P., Granato, M., Brand, M., Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., van Eeden, F.J., Jiang, Y.J., Heisenberg, C.P., Kelsh, R.N., Furutani-Seiki, M., Vogelsang, E., Beuchle, D., Schach, U., Fabian, C., and Nüsslein-Volhard, C. (1996) The identification of genes with unique and essential functions in the development of the zebrafish, Danio rerio. Development (Cambridge, England). 123:1-36

Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Mutations affecting morphogenesis during gastrulation and tail formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:143-151

Hammerschmidt, M., Pelegri, F., Mullins, M.C., Kane, D.A., van Eeden, F.J., Granato, M., Brand, M., Furutani-Seiki, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) dino and mercedes, two genes regulating dorsal development in the zebrafish embryo. Development (Cambridge, England). 123:95-102

Heisenberg, C.P., Brand, M., Jiang, Y.J., Warga, R.M., Beuchle, D., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Genes involved in forebrain development in the zebrafish, Danio rerio. Development (Cambridge, England). 123:191-203

Jiang, Y.J., Brand, M., Heisenberg, C.P., Beuchle, D., Furutani-Seiki, M., Kelsh, R.N., Warga, R.M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Mullins, M.C., Odenthal, J., van Eeden, F.J., and Nüsslein-Volhard, C. (1996) Mutations affecting neurogenesis and brain morphology in the zebrafish, Danio rerio. Development (Cambridge, England). 123:205-216

Kane, D.A., Hammerschmidt, M., Mullins, M.C., Maischein, H.M., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) The zebrafish epiboly mutants. Development (Cambridge, England). 123:47-55

Kane, D.A., Maischein, H.M., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Heisenberg-, C.P., Jiang, Y.J., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) The zebrafish early arrest mutants. Development (Cambridge, England). 123:57-66

Karlstrom, R.O. and Kane, D.A. (1996) A flipbook of zebrafish embryogenesis. Development (Cambridge, England). 123:461

Kelsh, R.N., Brand, M., Jiang, Y.J., Heisenberg, C.P., Lin, S., Haffter, P., Odenthal, J., Mullins, M.C., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Kane, D.A., Warga, R.M., Beuchle, D., Vogelsang, L., and Nüsslein-Volhard, C. (1996) Zebrafish pigmentation mutations and the processes of neural crest development. Development (Cambridge, England). 123:369-389

Mullins, M.C., Hammerschmidt, M., Kane, D.A., Odenthal, J., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Heisenberg, C.P., Jiang, Y.J., Kelsh, R.N., and Nüsslein-Volhard, C. (1996) Genes establishing dorsoventral pattern formation in the zebrafish embryo: the ventral specifying genes. Development (Cambridge, England). 123:81-93

Odenthal, J., Haffter, P., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting the formation of the notochord in the zebrafish, Danio rerio. Development (Cambridge, England). 123:103-115

Odenthal, J., Rossnagel, K., Haffter, P., Kelsh, R.N., Vogelsang, E., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Mutations affecting xanthophore pigmentation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:391-398

Piotrowski, T., Schilling, T.F., Brand, M., Jiang, Y.J., Heisenberg, C.P., Beuchle, D., Grandel, H., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Haffter, P., Hammerschmidt, M., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. II. Anterior arches and cartilage differentiation. Development (Cambridge, England). 123:345-356

Ransom, D.G., Haffter, P., Odenthal, J., Brownlie, A., Vogelsang, E., Kelsh, R.N., Brand, M., van Eeden, F.J., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Mullins, M.C., and Nüsslein-Volhard, C. (1996) Characterization of zebrafish mutants with defects in embryonic hematopoiesis. Development (Cambridge, England). 123:311-319

Schilling, T.F., Piotrowski, T., Grandel, H., Brand, M., Heisenberg, C.P., Jiang, Y.J., Beuchle, D., Hammerschmidt, M., Kane, D.A., Mullins, M.C., van Eeden, F.J., Kelsh, R.N., Furutani-Seiki, M., Granato, M., Haffter, P., Odenthal, J., Warga, R.M., Trowe, T., and Nüsslein-Volhard, C. (1996) Jaw and branchial arch mutants in zebrafish. I. Branchial arches. Development (Cambridge, England). 123:329-344

van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki-, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., Allende, M.L., Weinberg, E.S., and Nüsslein-Volhard, C. (1996) Mutations affecting somite formation and patterning in the zebrafish, Danio rerio. Development (Cambridge, England). 123:153-164

van Eeden, F.J., Granato, M., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., Warga, R.M., and Nüsslein-Volhard, C. (1996) Genetic analysis of fin formation in the zebrafish, Danio rerio. Development (Cambridge, England). 123:255-262

Whitfield, T.T., Granato, M., van Eeden, F.J., Schach, U., Brand, M., Furutani-Seiki, M., Haffter, P., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Mullins, M.C., Odenthal, J., and Nüsslein-Volhard, C. (1996) Mutations affecting development of the zebrafish inner ear and lateral line. Development (Cambridge, England). 123:241-254

Haffter, P., Odenthal, J., Mullins, M.C., Lin, S., Farrell, M.J., Vogelsang, E., Haas, F., Brand, M., van Eeden, F.J.M., Furutani-Seiki, M., Granato, M., Hammerschmidt, M., Heisenberg, C.P., Jiang, Y.J., Kane, D.A., Kelsh, R.N., Hopkins, N., and Nüsslein-Volhard, C. (1996) Mutations affecting pigmentation and shape of the adult zebrafish. Development genes and evolution. 206(4):260-276

Melby, A.E., Warga, R.M., and Kimmel, C.B. (1996) Specification of cell fates at the dorsal margin of the zebrafish gastrula. Development (Cambridge, England). 122:2225-2237

Schneider, S., Steinbeisser, H., Warga, R.M., and Hausen, P. (1996) ß-catenin translocation into nuclei demarcates the dorsalizing centers in frog and fish embryos. Mechanisms of Development. 57:191-198

Warga, R.M. (1996) Origin and specification of the endoderm in the zebrafish. Ph.D. Thesis.

Kimmel, C.B., Warga, R.M., and Kane, D.A. (1994) Cell cycles and clonal strings during formation of the zebrafish central nervous system. Development (Cambridge, England). 120:265-276

Kane, D.A. and Kimmel, C.B. (1993) The zebrafish midblastula transition. Development (Cambridge, England). 119:447-456

Kimmel, C.B., Molven, A., Ellis, T.J., Hatta, K., Ho, R.K., Kane, D.A., Schilling, T.F., Walker, C., and Warga, R.M. (1993) Developmental and mutational analysis of body pattern formation: the zebrafish model. In Physiological and Biochemical Aspects of Fish Development, Walther-B-T. and Fyhn-H-J., eds., Bergen, Norway: University of Bergen Press. :22-29

Kane, D.A., Warga, R.M., and Kimmel, C.B. (1992) Mitotic domains in the early embryo of the zebrafish. Nature. 360:735-737

Kane, D.A. (1991) Zebrafish midblastula transition: the onset of zygotic control during development. Ph.D. Thesis.

Kimmel, C.B., Kane, D.A., and Ho, R.K. (1991) Lineage specification during early embryonic development of the zebrafish. In Cell-Cell Interactions in Early Development, J. Gerhart, ed., Wiley, N.Y.. :203-225

Ho, R.K. and Kane, D.A. (1990) Cell-autonomous action of zebrafish spt-1 mutation in specific mesodermal precursors. Nature. 348:728-730

Kimmel, C.B., Warga, R.M., and Schilling, T.F. (1990) Origin and organization of the zebrafish fate map. Development (Cambridge, England). 108:581-594

Warga, R.M. and Kimmel, C.B. (1990) Cell movements during epiboly and gastrulation in zebrafish. Development (Cambridge, England). 108:569-580

Kimmel, C.B., Kane, D.A., Walker, C., Warga, R.M., and Rothman, M.B. (1989) A mutation that changes cell movement and cell fate in the zebrafish embryo. Nature. 337:358-362

Schilling, T.F., Warga, R.M., and Kimmel, C.B. (1989) Cranial muscles and motoneurons that innervate them originate from the same axial levels in the zebrafish. Soc. Neurosci. Abstr.. 15:810

Kimmel, C.B. and Warga, R.M. (1988) Cell lineage and developmental potential of cells in the zebrafish embryo. Trends in genetics : TIG. 4:68-74

Kimmel, C.B. and Warga, R.M. (1987) Indeterminate cell lineage of the zebrafish embryo. Developmental Biology. 124:269-280

Kimmel, C.B. and Warga, R.M. (1987) Cell lineages generating axial muscle in the zebrafish embryo. Nature. 327:234-237

Kimmel, C.B. and Warga, R.M. (1987) Cell lineages and movements in the formation of the zebrafish embryonic axis. Soc. Neurosci. Abstr.. 13:891

Kimmel, C.B. and Warga, R.M. (1986) Tissue specific cell lineages originate in the gastrula of the zebrafish. Science (New York, N.Y.). 231:356-368

Kimmel, C.B. and Warga, R.M. (1985) Embryonic lineages and migrations of cells during epiboly and axis formation in the zebrafish. Journal of cellular biochemistry. (Suppl.) 9B:272

Kimmel, C.B., Warga, R., and Law, R.D. (1984) Cellular lineages forming the zebrafish nervous system. Soc. Neurosci. Abstr.. 10:1044