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Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-970507-55
Axel Meyer Lab
PI/Director: Meyer, Axel
Contact Person:
Email:
URL: http://www.evolutionsbiologie.uni-konstanz.de/
Address: Department of Biology Evolutionary Biology University of Konstanz Universitatstrasse 10 Konstanz, D-78457 Germany
Country: Germany
Phone: 49-7531-884163
Fax: 49-7531-883018
Line Designation: kn


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 3 genomic features


STATEMENT OF RESEARCH INTERESTS
We are interested in the (1) evolutionary relationships among fishes, (2) the evolution of developmental mechanisms that led to different adult morphologies, and (3) the evolutionary patterns and processes that control the evolution of developmental genes such as hedgehog and Hox genes.

In particular we are interested in studying, from a comparative, evolutionary perspective, the developmental mechanisms in various species of zebrafish and cichlid fishes. Cichlid fishes have an evolutionary key-innovation that is believed to be at least partly responsible for their evolutionary succes, a second set of jaws that is evolutionarily derived from a modified set of gill arches. Using methods and lessons from the zebrafish model we hope to gain understanding of the developmental modifications that led from a general zebrafish morphology to a more specialized cichlid phenotype.

The group of Gerrit Begemann is further interested in the mechanisms by which signalling through retinoic acid participates in patterning of the nervous system and the pectoral fins of the developing zebrafish embryo. Moreover, we study the function and developmental regulation of a subset of T-box (tbx) genes, which are members of a large class of transcription factors, during the development of mesodermal structures in the head and trunk.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Woltering, J.M., Holzem, M., Schneider, R.F., Nanos, V., Meyer, A. (2018) The skeletal ontogeny of Astatotilapia burtoni - a direct-developing model system for the evolution and development of the teleost body plan. BMC Developmental Biology. 18:8
Hulsey, C.D., Fraser, G.J., Meyer, A. (2016) Biting into the Genome to Phenome Map: Developmental Genetic Modularity of Cichlid Fish Dentitions. Integrative and Comparative Biology. 56(3):373-88
Braasch, I., Gehrke, A.R., Smith, J.J., Kawasaki, K., Manousaki, T., Pasquier, J., Amores, A., Desvignes, T., Batzel, P., Catchen, J., Berlin, A.M., Campbell, M.S., Barrell, D., Martin, K.J., Mulley, J.F., Ravi, V., Lee, A.P., Nakamura, T., Chalopin, D., Fan, S., Wcisel, D., Cañestro, C., Sydes, J., Beaudry, F.E., Sun, Y., Hertel, J., Beam, M.J., Fasold, M., Ishiyama, M., Johnson, J., Kehr, S., Lara, M., Letaw, J.H., Litman, G.W., Litman, R.T., Mikami, M., Ota, T., Saha, N.R., Williams, L., Stadler, P.F., Wang, H., Taylor, J.S., Fontenot, Q., Ferrara, A., Searle, S.M., Aken, B., Yandell, M., Schneider, I., Yoder, J.A., Volff, J.N., Meyer, A., Amemiya, C.T., Venkatesh, B., Holland, P.W., Guiguen, Y., Bobe, J., Shubin, N.H., Di Palma, F., Alföldi, J., Lindblad-Toh, K., Postlethwait, J.H. (2016) The spotted gar genome illuminates vertebrate evolution and facilitates human-teleost comparisons. Nature Genetics. 48(4):427-37
Kratochwil, C.F., Sefton, M.M., Meyer, A. (2015) Embryonic and larval development in the Midas cichlid fish species flock (Amphilophus spp.): a new evo-devo model for the investigation of adaptive novelties and species differences. BMC Developmental Biology. 15:12
Feiner, N., Meyer, A., Kuraku, S. (2014) Evolution of the vertebrate Pax4/6 class of genes with focus on its novel member, the Pax10 gene. Genome biology and evolution. 6(7):1635-51
Amemiya, C.T., Alfoldi, J., Lee, A.P., Fan, S., Philippe, H., MacCallum, I., Braasch, I., Manousaki, T., Schneider, I., Rohner, N., Organ, C., Chalopin, D., Smith, J.J., Robinson, M., Dorrington, R.A., Gerdol, M., Aken, B., Biscotti, M.A., Barucca, M., Baurain, D., Berlin, A.M., Blatch, G.L., Buonocore, F., Burmester, T., Campbell, M.S., Canapa, A., Cannon, J.P., Christoffels, A., de Moro, G., Edkins, A.L., Fan, L., Fausto, A.M., Feiner, N., Forconi, M., Gamieldien, J., Gnerre, S., Gnirke, A., Goldstone, J.V., Haerty, W., Hahn, M.E., Hesse, U., Hoffmann, S., Johnson, J., Karchner, S.I., Karaku, S., Lara, M., Levin, J.Z., Litman, G.W., Mauceli, E., Miyake, T., Mueller, M.G., Nelson, D.R., Nitsche, A., Olmo, E., Ota, T., Pallavicini, A., Panji, S., Picone, B., Ponting, C.P., Prohaska, S.J., Przybylski, D., Saha, N.R., Ravi, V., Ribeiro, F.J., Sauka-Spengler, T., Scapigliati, G., Searle, S.M.J., Sharpe, T., Simakov, O., Stadler, P.F., Stegeman, J.J., Sumiyama, K., Tabbaa, D., Tafer, H., Turner-Maier, J., van Heusden, P., White, S., Williams, L., Yandell, M., Brinkmann, H., Volff, J.N., Tabin, C.J., Shubin, N., Schartl, M., Jaffe, D.B., Postlethwait, J.H., Venkatesh, B., Palma, F.D., Lander, E.S., Meyer, A., and Lindblad-Toh, K. (2013) The African coelacanth genome provides insights into tetrapod evolution. Nature. 496:311-316
Feiner, N., Murakami, Y., Breithut, L., Mazan, S., Meyer, A., and Kuraku, S. (2013) Saltatory evolution of the ectodermal neural cortex (ENC) gene family at the vertebrate origin. Genome biology and evolution. 5(8):1485-502
Manousaki, T., Feiner, N., Begemann, G., Meyer, A., and Kuraku, S. (2011) Co-orthology of Pax4 and Pax6 to the fly eyeless gene: molecular phylogenetic, comparative genomic, and embryological analyses. Evolution & development. 13(5):448-459
Gunter, H.M., Clabaut, C., Salzburger, W., and Meyer, A. (2011) Identification and Characterization of Gene Expression Involved in the Coloration of Cichlid Fish Using Microarray and qRT-PCR Approaches. Journal of molecular evolution. 72(2):127-37
Lang, M., Hadzhiev, Y., Siegel, N., Amemiya, C.T., Parada, C., Strähle, U., Becker, M.B., Muller, F., and Meyer, A. (2010) Conservation of shh cis-regulatory architecture of the coelacanth is consistent with its ancestral phylogenetic position. EvoDevo. 1(1):11
Gibert, Y., Bernard, L., Debiais-Thibaud, M., Bourrat, F., Joly, J.S., Pottin, K., Meyer, A., Retaux, S., Stock, D.W., Jackman, W.R., Seritrakul, P., Begemann, G., and Laudet, V. (2010) Formation of oral and pharyngeal dentition in teleosts depends on differential recruitment of retinoic acid signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 24(9):3298-3309
Feiner, N., Begemann, G., Renz, A.J., Meyer, A., and Kuraku, S. (2009) The origin of bmp16, a novel Bmp2/4 relative, retained in teleost fish genomes. BMC Evolutionary Biology. 9:277
Salzburger, W., Renn, S.C., Steinke, D., Braasch, I., Hofmann, H.A., and Meyer, A. (2008) Annotation of expressed sequence tags for the East African cichlid fish Astatotilapia burtoni and evolutionary analyses of cichlid ORFs. BMC Genomics. 9:96
Pittlik, S., Domingues, S., Meyer, A., and Begemann, G. (2008) Expression of zebrafish aldh1a3 (raldh3) and absence of aldh1a1 in teleosts. Gene expression patterns : GEP. 8(3):141-147
Fukamachi, S., and Meyer, A. (2007) Evolution of receptors for growth hormone and somatolactin in fish and land vertebrates: lessons from the lungfish and sturgeon orthologues. Journal of molecular evolution. 65(4):359-372
Siegel, N., Hoegg, S., Salzburger, W., Braasch, I., and Meyer, A. (2007) Comparative genomics of ParaHox clusters of teleost fishes: gene cluster breakup and the retention of gene sets following whole genome duplications. BMC Genomics. 8:312
Luo, J., Stadler, P.F., He, S., and Meyer, A. (2007) PCR survey of hox genes in the goldfish Carassius auratus auratus. Journal of experimental zoology. Part B, Molecular and developmental evolution. 308(3):250-258
Luo, J., Lang, M., Salzburger, W., Siegel, N., Stolting, K.N., and Meyer, A. (2006) A BAC library for the goldfish Carassius auratus auratus (Cyprinidae, Cypriniformes). Journal of experimental zoology. Part B, Molecular and developmental evolution. 306(6):567-574
Gibert, Y., Gajewski, A., Meyer, A., and Begemann, G. (2006) Induction and prepatterning of the zebrafish pectoral fin bud requires axial retinoic acid signaling. Development (Cambridge, England). 133(14):2649-2659
Braasch, I., Salzburger, W., and Meyer, A. (2006) Asymmetric evolution in two fish-specifically duplicated receptor tyrosine kinase paralogons involved in teleost coloration. Mol. Biol. Evol.. 23(6):1192-1202
Steinke, D., Salzburger, W., Braasch, I., and Meyer, A. (2006) Many genes in fish have species-specific asymmetric rates of molecular evolution. BMC Genomics. 7(1):20
Gu, W., Gibert, Y., Wirth, T., Elischer, A., Bloch, W., Meyer, A., Steinlein, O.K., and Begemann, G. (2005) Using Gene-History and Expression Analyses to Assess the Involvement of LGI Genes in Human Disorders. Mol. Biol. Evol.. 22(11):2209-2216
Gibert, Y., McMillan, D.R., Kayes-Wandover, K., Meyer, A., Begemann, G., and White, P.C. (2005) Analysis of the very large G-protein coupled receptor gene (Vlgr1/Mass1/USH2C) in zebrafish. Gene. 353(2):200-206
Chen, W.J., Orti, G., and Meyer, A. (2004) Novel evolutionary relationship among four fish model systems. Trends in genetics : TIG. 20(9):424-431
Hoegg, S., Brinkmann, H., Taylor, J.S., and Meyer, A. (2004) Phylogenetic timing of the fish-specific genome duplication correlates with the diversification of teleost fish. Journal of molecular evolution. 59(2):190-203
Begemann, G., Marx, M., Mebus, K., Meyer, A., and Bastmeyer, M. (2004) Beyond the neckless phenotype: influence of reduced retinoic acid signaling on motor neuron development in the zebrafish hindbrain. Developmental Biology. 271(1):119-129
Santini, S., Boore, J.L., and Meyer, A. (2003) Evolutionary conservation of regulatory elements in vertebrate hox gene clusters. Genome research. 13(6):1111-1122
Taylor, J.S., Braasch, I., Frickey, T., Meyer, A., and van de Peer, Yves (2003) Genome duplication, a trait shared by 22,000 species of ray-finned fish. Genome research. 13(3):382-390
van de Peer, Y., Taylor, J.S., and Meyer, A. (2003) Are all fishes ancient polyploids?. Journal of structural and functional genomics. 3(1-4):65-73
van de Peer, Y., Frickey, T., Taylor, J., and Meyer, A. (2002) Dealing with saturation at the amino acid level: a case study based on anciently duplicated zebrafish genes. Gene. 295(2):205-211
Begemann, G., Gibert, Y., Meyer, A., and Ingham, P.W. (2002) Cloning of zebrafish T-box genes tbx15 and tbx18 and their expression during embryonic development. Mechanisms of Development. 114(1-2):137
Málaga-Trillo, E., Laessing, U., Lang, D.M., Meyer, A., and Stürmer, C.A.O. (2002) Evolution of duplicated reggie genes in zebrafish and goldfish. Journal of molecular evolution. 54(2):235-245
Taylor, J.S., van de Peer, Y., Braasch, I., and Meyer, A. (2001) Comparative genomics provides evidence for an ancient genome duplication event in fish. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 356(1414):1661-1679
van de Peer, Y., Taylor, J.S., Braasch, I., and Meyer, A. (2001) The ghost of selection past: rates of evolution and functional divergence of anciently duplicated genes. Journal of molecular evolution. 53(4-5):436-446
Málaga-Trillo, E. and Meyer, A. (2001) Genome duplications and accelerated evolution of Hox genes and cluster architecture in teleost fishes. American zoologist. 41(3):676-686
Taylor, J.S., van de Peer, Y., and Meyer, A. (2001) Genome duplication, divergent resolution and speciation. Trends in genetics : TIG. 17:299-301
Meyer, A. and Málaga-Trillo, E. (1999) More fishy tales about hox genes. Current biology : CB. 9(6):R210-213
Meyer, A. (1998) Hox gene variation and evolution. Nature. 391:225
Zardoya, R., Abouheif, E., and Meyer, A. (1996) Evolution and orthology of hedgehog genes. Trends in genetics : TIG. 12:496-497
Zardoya, R., Abouheif, E., and Meyer, A. (1996) Evolutionary analyses of hedgehog and Hoxd-10 genes in fish species closely related to the zebrafish. Proc. Natl. Acad. Sci. USA. 93:13036-13041
Graser, R., O'hUigin, C., Vincek, V., Meyer, A., and Klein, J. (1996) Trans-species polymorphism of class II mhc loci in danio fishes. Immunogenetics. 44:36-48
Meyer, A., Ritchie, P., and Witte, K.E. (1995) Predicting developmental processes from evolutionary patterns: a molecular phylogeny of the zebrafish (Danio rerio) and its relatives. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 349:103-111
Meyer, A., Biermann, C.H., and Ortí, G. (1993) The phylogenetic position of the zebrafish (Danio rerio), a model system in developmental biology: an invitation to the comparative method. Proc. R. Soc. Lond.. 252:231-236