Lab
Steiner Lab
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Statement of Research Interest
The long-term interest of our lab has been the evolution and development of the immune system. Our current goal is to understand the early development of cells in the lymphocytic lineage and of the organs in which these cells differentiate. Despite a wealth of information about later stages, little is known about early steps in the differentiation of lymphocytes and the thymic primordium, including commitment to the lymphocytic lineages and homing of lymphocytic progenitors to the thymus. We have developed a visual assay for formation of the thymus, which we are currently using to screen mutagenized fish for defects in thymus and thymocyte development. In addition, we are investigating the genomics structure of immunoglobulin genes as well as the changes involved in the formation of the mature adaptive immune system, more specifically V(D)J recombination and somatic hypermutation and their regulation during development.
Lab Members
- Danilova, N., Wilkes, M., Bibikova, E., Youn, M.Y., Sakamoto, K.M., Lin, S. (2018) Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia. Scientific Reports. 8:5165
- Bibikova, E., Youn, M.Y., Danilova, N., Ono-Uruga, Y., Konto-Ghiorghi, Y., Ochoa, R., Narla, A., Glader, B., Lin, S., Sakamoto, K.M. (2014) TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors. Blood. 124(25):3791-8
- Danilova, N., Bibikova, E., Covey, T.M., Nathanson, D., Dimitrova, E., Konto, Y., Lindgren, A., Glader, B., Radu, C.G., Sakamoto, K.M., Lin, S. (2014) The role of DNA damage response in zebrafish and cellular models of Diamond Blackfan Anemia. Disease models & mechanisms. 7(7):895-905
- Zhang, Y., Morimoto, K., Danilova, N., Zhang, B., and Lin, S. (2012) Zebrafish Models for Dyskeratosis Congenita Reveal Critical Roles of p53 Activation Contributing to Hematopoietic Defects through RNA Processing. PLoS One. 7(1):e30188
- Danilova, N., Sakamoto, K.M., and Lin, S. (2011) Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects. British journal of haematology. 152(2):217-228
- Zimmerman, A.M., Moustafa, F.M., Romanowski, K.E., and Steiner, L.A. (2011) Zebrafish immunoglobulin IgD: Unusual exon usage and quantitative expression profiles with IgM and IgZ/T heavy chain isotypes. Molecular immunology. 48(15-16):2220-3
- Danilova, N., Kumagai, A., and Lin, J. (2010) p53 Upregulation Is a Frequent Response to Deficiency of Cell-Essential Genes. PLoS One. 5(12):e15938
- Danilova, N., Sakamoto, K.M., and Lin, S. (2008) Role of p53 family in birth defects: Lessons from zebrafish. Birth defects research. Part C, Embryo today : reviews. 84(3):215-227
- Danilova, N., Sakamoto, K.M., and Lin, S. (2008) Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family. Blood. 112(13):5228-5237
- Zimmerman, A.M., Yeo, G., Howe, K., Maddox, B.J., and Steiner, L.A. (2008) Immunoglobulin light chain (IgL) genes in zebrafish: Genomic configurations and inversional rearrangements between (V(L)-J(L)-C(L)) gene clusters. Developmental and comparative immunology. 32(4):421-434
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