ZFIN Lab: Lundegaard Lab

ZFIN ID: ZDB-LAB-230713-1

ZFIN ID: ZDB-LAB-230713-1

Lundegaard Lab

PI/Director:	Lundegaard, Pia Rengtved
Contact Person:	Lundegaard, Pia Rengtved
Email:	plundegaard@sund.ku.dk
URL:	https://bmi.ku.dk/english/research/molecular-cardiology-and-membrane-proteins/lundegaard-group/
Address:	University of Copenhagen, Faculty of Health and Medical Sciences, Blegdamsvej 3B, 2200 Copenhagen N, Denmark.
Country:	Denmark
Phone:	00 45 21 15 27 91‬
Fax:
Line Designation:	cph

GENOMIC FEATURES ORIGINATING FROM THIS LAB No data available

STATEMENT OF RESEARCH INTERESTS

Our lab interests are focused on understanding the molecular mechanisms underlying vertebrate heart development and function. We have a particular interest in how the atrial dysfunction leads to atrial cardiomyopathy, atrial fibrillation, and other types of arrhythmias.

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Ambrosio, E.M.G., Bailey, C.S.L., Unterweger, I.A., Christensen, J.B., Bruchez, M.P., Lundegaard, P.R., Ober, E.A. (2024) LiverZap: a chemoptogenetic tool for global and locally restricted hepatocyte ablation to study cellular behaviours in liver regeneration. Development (Cambridge, England). 151(4):

Unterweger, I.A., Klepstad, J., Hannezo, E., Lundegaard, P.R., Trusina, A., Ober, E.A. (2023) Lineage tracing identifies heterogeneous hepatoblast contribution to cell lineages and postembryonic organ growth dynamics. PLoS Biology. 21:e3002315e3002315

Mocho, J.P., Lang, F., Valentin, G., Bedu, S., McKimm, R., Ramos, J., Saavedra Torres, Y., Wheatley, S.E., Higgins, J., Millington, M.E., Lundegaard, P.R., Chamorro Valverde, R., Jenčič, V., von Krogh, K. (2022) A Multi-Site Assessment of Anesthetic Overdose, Hypothermic Shock, and Electrical Stunning as Methods of Euthanasia for Zebrafish (Danio rerio) Embryos and Larvae. Biology. 11(4):

Bensimon-Brito, A., Boezio, G.L.M., Cardeira-da-Silva, J., Wietelmann, A., Ramkumar, S., Lundegaard, P.R., Helker, C.S.M., Ramadass, R., Piesker, J., Nauerth, A., Mueller, C., Stainier, D.Y.R. (2021) Integration of multiple imaging platforms to uncover cardiovascular defects in adult zebrafish. Cardiovascular research. 118(12):2665-2687

Linscheid, N., Santos, A., Poulsen, P.C., Mills, R.W., Calloe, K., Leurs, U., Ye, J.Z., Stolte, C., Thomsen, M.B., Bentzen, B.H., Lundegaard, P.R., Olesen, M.S., Jensen, L.J., Olsen, J.V., Lundby, A. (2021) Quantitative proteome comparison of human hearts with those of model organisms. PLoS Biology. 19:e3001144

Collins, M.M., Ahlberg, G., Hansen, C.V., Guenther, S., Marín-Juez, R., Sokol, A.M., El-Sammak, H., Piesker, J., Hellsten, Y., Olesen, M.S., Stainier, D.Y.R., Lundegaard, P.R. (2019) Early sarcomere and metabolic defects in a zebrafish pitx2c cardiac arrhythmia model. Proceedings of the National Academy of Sciences of the United States of America. 116(48):24115-24121

Sokol, A.M., Uszczynska-Ratajczak, B., Collins, M.M., Bazala, M., Topf, U., Lundegaard, P.R., Sugunan, S., Guenther, S., Kuenne, C., Graumann, J., Chan, S.S.L., Stainier, D.Y.R., Chacinska, A. (2019) Correction: Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish. PLoS Genetics. 15:e1007972

Sokol, A.M., Uszczynska-Ratajczak, B., Collins, M.M., Bazala, M., Topf, U., Lundegaard, P.R., Sugunan, S., Guenther, S., Kuenne, C., Graumann, J., Chan, S.S.L., Stainier, D.Y.R., Chacinska, A. (2018) Loss of the Mia40a oxidoreductase leads to hepato-pancreatic insufficiency in zebrafish. PLoS Genetics. 14:e1007743

Ahlberg, G., Refsgaard, L., Lundegaard, P.R., Andreasen, L., Ranthe, M.F., Linscheid, N., Nielsen, J.B., Melbye, M., Haunsø, S., Sajadieh, A., Camp, L., Olesen, S.P., Rasmussen, S., Lundby, A., Ellinor, P.T., Holst, A.G., Svendsen, J.H., Olesen, M.S. (2018) Rare truncating variants in the sarcomeric protein titin associate with familial and early-onset atrial fibrillation. Nature communications. 9:4316

Skarsfeldt, M.A., Bomholtz, S.H., Lundegaard, P.R., Lopez-Izquierdo, A., Tristani-Firouzi, M., Bentzen, B.H. (2018) Atrium-specific ion channels in the zebrafish-A role of I_KACh in atrial repolarization.. Acta physiologica (Oxford, England). 223(3):e13049

Lundegaard, P.R., Anastasaki, C., Grant, N.J., Sillito, R.R., Zich, J., Zeng, Z., Paranthaman, K., Larsen, A.P., Armstrong, J.D., Porteous, D.J., Patton, E.E. (2015) MEK Inhibitors Reverse cAMP-Mediated Anxiety in Zebrafish. Chemistry & Biology. 22(10):1335-46

Colanesi, S., Taylor, K.L., Temperley, N.D., Lundegaard, P.R., Liu, D., North, T.E., Ishizaki, H., Kelsh, R.N., and Patton, E.E. (2012) Small molecule screening identifies targetable zebrafish pigmentation pathways. Pigment cell & melanoma research. 25(2):131-143

Richardson, J., Lundegaard, P.R., Reynolds, N.L., Dorin, J.R., Porteous, D.J., Jackson, I.J., and Patton, E.E. (2008) mc1r Pathway regulation of zebrafish melanosome dispersion. Zebrafish. 5(4):289-295