ZFIN Lab: Villablanca Lab

ZFIN ID: ZDB-LAB-200625-1

ZFIN ID: ZDB-LAB-200625-1

Villablanca Lab

PI/Director:	Villablanca, Eduardo J.
Contact Person:	Villablanca, Eduardo J.
Email:	eduardo.villablanca@ki.se
URL:
Address:	Center of Molecular Medicine (CMM) L8:03 171 76 Stockholm
Country:	Sweden
Phone:	+46-(0)73-628 22 89
Fax:
Line Designation:	uu

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 2 genomic features

STATEMENT OF RESEARCH INTERESTS

Our lab is seeking to understand the genetic, cellular and environmental contribution towards inflammatory bowel disease (IBD) susceptibility. We have developed a research program that integrates cellular immunology, bioinformatics and the creation of novel in vivo models to ultimately interrogate the function of IBD-associated polymorphisms as well as to study host-microbiota interactions. In particular, we are trying to understand how deregulation of intestinal immune homeostasis might lead to IBD and trying to discover the function of IBD-risk genes identified by Genome Wide Association Studies (GWAS). To discover the function of IBD-risk genes, we focus on biological processes that are involved at the initiation (priming of adaptive immune responses), progression (chronic inflammation) or resolution (tissue repair) of IBD. To translate genetic mutations to function, we have developed an innovative pipeline that integrate bioinformatics and animal models, including zebrafish and mouse, to ultimately validate candidate mutations in human tissues by using organoids.

LAB MEMBERS

Das, Srustidhar Post-Doc	Frede, Annika Post-Doc	Morales Castro, Rodrigo A. Post-Doc
Parigi, Martina Post-Doc	Sorini, Chiara Post-Doc	Tripathi, Kumar P. Post-Doc
Cardoso, Rebeca Graduate Student	Diaz, Oscar E. Graduate Student	Kulmala, Katja Graduate Student
Luo, Xinxin Graduate Student	Inampudi, Santoshnisikranth Research Staff

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Morales, R.A., Rabahi, S., Diaz, O.E., Salloum, Y., Kern, B.C., Westling, M., Luo, X., Parigi, S.M., Monasterio, G., Das, S., Hernández, P.P., Villablanca, E.J. (2022) Interleukin-10 regulates goblet cell numbers through Notch signaling in the developing zebrafish intestine. Mucosal immunology. 15(5):940-951

Diaz, O.E., Sorini, C., Morales, R.A., Luo, X., Frede, A., Krais, A.M., Chávez, M.N., Wincent, E., Das, S., Villablanca, E.J. (2021) Perfluorooctanesulfonic acid modulates barrier function and systemic T cell homeostasis during intestinal inflammation. Disease models & mechanisms. 14(12):

Kaya, B., Doñas, C., Wuggenig, P., Diaz, O.E., Morales, R.A., Melhem, H., Swiss IBD. Cohort Investigators, Hernández, P.P., Kaymak, T., Das, S., Hruz, P., Franc, Y., Geier, F., Ayata, C.K., Villablanca, E.J., Niess, J.H. (2020) Lysophosphatidic Acid-Mediated GPR35 Signaling in CX3CR1⁺ Macrophages Regulates Intestinal Homeostasis. Cell Reports. 32:107979

Parada-Kusz, M., Penaranda, C., Hagedorn, E.J., Clatworthy, A., Nair, A.V., Henninger, J.E., Ernst, C., Li, B., Riquelme, R., Jijon, H., Villablanca, E.J., Zon, L.I., Hung, D., Allende, M.L. (2018) Generation of mouse-zebrafish hematopoietic tissue chimeric embryos for hematopoiesis and host-pathogen interaction studies. Disease models & mechanisms. 11(11):