ZFIN ID: ZDB-LAB-170210-2
Ruilin Zhang Lab
PI/Director: Zhang, Ruilin
Contact Person: Zhang, Ruilin
Email: zhangruilin@whu.edu.cn
URL: http://wbm.whu.edu.cn/info/1350/5912.htm
Address: Wuhan University School of Basic Medical Sciences 185 Donghu Road, Wuchang District, Wuhan 430071, CHINA
Country: China
Phone: 86-27-68759795
Fax:
Line Designation: whu


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 20 genomic features


STATEMENT OF RESEARCH INTERESTS
Use zebrafish as model organism to study cardiovascular development and disease, regenerative medicine, signal transduction, cell fate determination and differentiation.


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Wang, Y., Zhu, Y., Wang, Y., Chang, Y., Geng, F., Ma, M., Gu, Y., Yu, A., Zhu, R., Yu, P., Sha, Z., Qi, S., Li, J., Zhao, W., Pan, W., Zhang, R., Yu, F.X. (2023) Proteolytic activation of angiomotin by DDI2 promotes angiogenesis. The EMBO journal. 42(15):e112900
Chang, C., Li, H., Zhang, R. (2023) Response Letter to: Zebrafish: An emerging and expedient model for liver studies?. Liver international : official journal of the International Association for the Study of the Liver. 43(8):1841
Chang, C., Li, H., Zhang, R. (2023) Zebrafish facilitate non-alcoholic fatty liver disease research: Tools, models and applications. Liver international : official journal of the International Association for the Study of the Liver. 43(7):1385-1398
Ma, J., Shao, X., Geng, F., Liang, S., Yu, C., Zhang, R. (2022) Ercc2/Xpd deficiency results in failure of digestive organ growth in zebrafish with elevated nucleolar stress. iScience. 25:104957
Ma, J., Tang, D., Gao, P., Liang, S., Zhang, R. (2022) Knockout of Shelterin subunit genes in zebrafish results in distinct outcomes. Biochemical and Biophysical Research Communications. 617:22-29
Wang, W., Hu, Y.F., Pang, M., Chang, N., Yu, C., Li, Q., Xiong, J.W., Peng, Y., Zhang, R. (2021) BMP and Notch Signaling Pathways differentially regulate Cardiomyocyte Proliferation during Ventricle Regeneration. International journal of biological sciences. 17:2157-2166
Peng, Y., Wang, W., Fang, Y., Hu, H., Chang, N., Pang, M., Hu, Y.F., Li, X., Long, H., Xiong, J.W., Zhang, R. (2021) Corrigendum: Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial-Mesenchymal Transition-Like Response During Ventricle Regeneration. Frontiers in cell and developmental biology. 9:699796
Geng, F., Ma, J., Li, X., Hu, Z., Zhang, R. (2021) Hemodynamic Forces Regulate Cardiac Regeneration-Responsive Enhancer Activity during Ventricle Regeneration. International Journal of Molecular Sciences. 22(8):
Peng, Y., Wang, W., Fang, Y., Hu, H., Chang, N., Pang, M., Hu, Y.F., Li, X., Long, H., Xiong, J.W., Zhang, R. (2021) Inhibition of TGF-β/Smad3 Signaling Disrupts Cardiomyocyte Cell Cycle Progression and Epithelial-Mesenchymal Transition-Like Response During Ventricle Regeneration. Frontiers in cell and developmental biology. 9:632372
Shao, X., Fu, Y., Ma, J., Li, X., Lu, C., Zhang, R. (2020) Functional alterations and transcriptomic changes during zebrafish cardiac aging. Biogerontology. 21(5):637-652
Li, X., Lu, Q., Peng, Y., Geng, F., Shao, X., Zhou, H., Cao, Y., Zhang, R. (2020) Primary cilia mediate Klf2-dependant Notch activation in regenerating heart. Protein & cell. 11(6):433-445
Gálvez-Santisteban, M., Chen, D., Zhang, R., Serrano, R., Nguyen, C., Zhao, L., Nerb, L., Masutani, E.M., Vermot, J., Burns, C.G., Burns, C.E., Del Álamo, J.C., Chi, N.C. (2019) Hemodynamic-mediated endocardial signaling controls in vivo myocardial reprogramming. eLIFE. 8:
Chang, Y., Geng, F., Hu, Y., Ding, Y., Zhang, R. (2019) Zebrafish cysteine and glycine-rich protein 3 is essential for mechanical stability in skeletal muscles. Biochemical and Biophysical Research Communications. 511(3):604-611
Zhang, R., He, J., Wang, X., Pan, W., Cao, Y., Zu, Y., Jiang, Q., Du, J., Zhong, T.P. (2018) Report of the Fifth Zebrafish Research Conference of China. Zebrafish. 16(1):128-134
Yang, D., Zheng, X., Chen, S., Wang, Z., Xu, W., Tan, J., Hu, T., Hou, M., Wang, W., Gu, Z., Wang, Q., Zhang, R., Zhang, Y., Liu, Q. (2018) Sensing of cytosolic LPS through caspy2 pyrin domain mediates noncanonical inflammasome activation in zebrafish. Nature communications. 9:3052
Cao, X., Li, C., Xiao, S., Tang, Y., Huang, J., Zhao, S., Li, X., Li, J., Zhang, R., Yu, W. (2017) Acetylation promotes TyrRS nuclear translocation to prevent oxidative damage. Proceedings of the National Academy of Sciences of the United States of America. 114(4):687-692
Han, P., Bloomekatz, J., Ren, J., Zhang, R., Grinstein, J.D., Zhao, L., Burns, C.G., Burns, C.E., Anderson, R.M., Chi, N.C. (2016) Coordinating cardiomyocyte interactions to direct ventricular chamber morphogenesis. Nature. 534:700-4
Dickover, M., Hegarty, J.M., Ly, K., Lopez, D., Yang, H., Zhang, R., Tedeschi, N., Hsiai, T.K., Chi, N.C. (2014) The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis. Developmental Biology. 389:182-91
Zhang, R., Han, P., Yang, H., Ouyang, K., Lee, D., Lin, Y.F., Ocorr, K., Kang, G., Chen, J., Stainier, D.Y., Yelon, D., and Chi, N.C. (2013) In vivo cardiac reprogramming contributes to zebrafish heart regeneration. Nature. 498(7455):497-501
Dickover, M.S., Zhang, R., Han, P., and Chi, N.C. (2013) Zebrafish cardiac injury and regeneration models: a noninvasive and invasive in vivo model of cardiac regeneration. Methods in molecular biology (Clifton, N.J.). 1037:463-473
Zhang, R., Yang, J., Zhu, J., and Xu, X. (2009) Depletion of zebrafish Tcap leads to muscular dystrophy via disrupting sarcomere-membrane interaction, not sarcomere assembly. Human molecular genetics. 18(21):4130-4140
Sun, X., Hoage, T., Bai, P., Ding, Y., Chen, Z., Zhang, R., Huang, W., Jahangir, A., Paw, B., Li, Y.G., and Xu, X. (2009) Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One. 4(8):e6596
Huang, W., Zhang, R., and Xu, X. (2009) Myofibrillogenesis in the Developing Zebrafish Heart: A Functional Study of tnnt2. Developmental Biology. 331(2):237-249
Zhang, R., and Xu, X. (2009) Transient and transgenic analysis of the zebrafish ventricular myosin heavy chain (vmhc) promoter: An inhibitory mechanism of ventricle-specific gene expression. Developmental Dynamics : an official publication of the American Association of Anatomists. 238(6):1564-1573
Zhang, R. (2009) Molecular genetics of zebrafish Tcap : a causative gene for muscular dystrophy and cardiomyopathy. Ph.D. Thesis. :173p
Sun, X., Zhang, R., Lin, X., and Xu, X. (2008) Wnt3a Regulates the Development of Cardiac Neural Crest Cells by Modulating Expression of Cysteine-Rich Intestinal Protein 2 in Rhombomere 6. Circulation research. 102(7):831-839