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Zebrafish Publications of lab members

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• Das, I., Gad, H., Bräutigam, L., Pudelko, L., Tuominen, R., Höiom, V., Almlöf, I., Rajagopal, V., Hansson, J., Helleday, T., Egyházi Brage, S., Warpman Berglund, U. (2020) AXL and CAV-1 play a role for MTH1 inhibitor TH1579 sensitivity in cutaneous malignant melanoma. Cell death and differentiation. 27(7):2081-2098
• Pudelko, L., Rouhi, P., Sanjiv, K., Gad, H., Kalderén, C., Höglund, A., Squatrito, M., Schuhmacher, A.J., Edwards, S., Hägerstrand, D., Berglund, U.W., Helleday, T., Bräutigam, L. (2020) CORRECTION: Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. Oncotarget. 11:827
• Scaletti, E.R., Vallin, K.S., Bräutigam, L., Sarno, A., Berglund, U.W., Helleday, T., Stenmark, P., Jemth, A.S. (2020) MutT homologue 1 (MTH1) removes N6-methyl-dATP from the dNTP pool. The Journal of biological chemistry. 295(15):4761-4772
• Jemth, A.S., Gustafsson, R., Bräutigam, L., Henriksson, L., Vallin, K.S.A., Sarno, A., Almlöf, I., Homan, E., Rasti, A., Warpman Berglund, U., Stenmark, P., Helleday, T. (2018) MutT homologue 1 (MTH1) catalyzes the hydrolysis of mutagenic O6-methyl-dGTP. Nucleic acids research. 46(20):10888-10904
• Narwal, M., Jemth, A.S., Gustafsson, R., Almlöf, I., Warpman Berglund, U., Helleday, T., Stenmark, P. (2018) Crystal Structures and Inhibitor Interactions of Mouse and Dog MTH1 Reveal Species-Specific Differences in Affinity. Biochemistry. 57:593-603
• Pudelko, L., Edwards, S., Balan, M., Nyqvist, D., Al-Saadi, J., Dittmer, J., Almlöf, I., Helleday, T., Bräutigam, L. (2018) An orthotopic glioblastoma animal model suitable for high-throughput screenings. Neuro-Oncology. 20(11):1475-1484
• Pudelko, L., Rouhi, P., Sanjiv, K., Gad, H., Kalderén, C., Höglund, A., Squatrito, M., Schuhmacher, A.J., Edwards, S., Hägerstrand, D., Berglund, U.W., Helleday, T., Bräutigam, L. (2017) Glioblastoma and glioblastoma stem cells are dependent on functional MTH1. Oncotarget. 8:84671-84684
• Bräutigam, L., Pudelko, L., Jemth, A.S., Gad, H., Narwal, M., Gustafsson, R., Karsten, S., Carreras-Puigvert, J., Homan, E., Berndt, C., Warpman Berglund, U., Stenmark, P., Helleday, T. (2016) Hypoxic signaling and the cellular redox tumor environment determine sensitivity to MTH1 inhibition. Cancer research. 76(8):2366-75

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