ZFIN Lab: Vascular Signaling Group

ZFIN ID: ZDB-LAB-150420-1

Vascular Signaling Group

PI/Director:	Kroll, Jens
Contact Person:	Kroll, Jens
Email:	jens.kroll@medma.uni-heidelberg.de
URL:	http://www.angiolab.de or www. www.transregio23.de or www.umm.uni-heidelberg.de/ag/grk1874 or
Address:	Ludolf-Krehl-Str. 13-17, 68167 Mannheim, Germany
Country:	Germany
Phone:	+49 621 383 9965
Fax:	+49 621 383 9961
Line Designation:	uh

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 9 genomic features

STATEMENT OF RESEARCH INTERESTS

We use the zebrafish model trying to understand the formation and function of the vascular system. We are interested in novel signaling pathways and how these pathways contribute to endothelial cell formation, migration and proliferation. In addition, we have initiated experiments which aim to use zebrafish as a model for diabetes research.

LAB MEMBERS

Stoll, Sandra Post-Doc	Lodd, Elisabeth Graduate Student	Schmöhl, Felix Graduate Student
Sharma, Krishna Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Al-Dahmani, Z.M., Li, X., Wiggenhauser, L.M., Ott, H., Kruithof, P.D., Lunev, S., A Batista, F., Luo, Y., Dolga, A.M., Morton, N.M., Groves, M.R., Kroll, J., van Goor, H. (2022) Thiosulfate sulfurtransferase prevents hyperglycemic damage to the zebrafish pronephros in an experimental model for diabetes. Scientific Reports. 12:12077

Boger, M., Bennewitz, K., Wohlfart, D.P., Hausser, I., Sticht, C., Poschet, G., Kroll, J. (2022) Comparative Morphological, Metabolic and Transcriptome Analyses in elmo1^-/- , elmo2^-/- , and elmo3^-/- Zebrafish Mutants Identified a Functional Non-Redundancy of the Elmo Proteins. Frontiers in cell and developmental biology. 10:918529

Gegner, H.M., Mechtel, N., Heidenreich, E., Wirth, A., Cortizo, F.G., Bennewitz, K., Fleming, T., Andresen, C., Freichel, M., Teleman, A.A., Kroll, J., Hell, R., Poschet, G. (2022) Deep Metabolic Profiling Assessment of Tissue Extraction Protocols for Three Model Organisms. Frontiers in chemistry. 10:869732

Wiggenhauser, L.M., Metzger, L., Bennewitz, K., Soleymani, S., Boger, M., Tabler, C.T., Hausser, I., Sticht, C., Wohlfart, P., Volk, N., Heidenreich, E., Buettner, M., Hammes, H.P., Kroll, J. (2022) pdx1 Knockout Leads to a Diabetic Nephropathy-Like Phenotype in Zebrafish and Identifies Phosphatidylethanolamine as Metabolite Promoting Early Diabetic Kidney Damage. Diabetes. 71(5):1073-1080

Heinkele, F.J., Lou, B., Erben, V., Bennewitz, K., Poschet, G., Sticht, C., Kroll, J. (2021) Metabolic and Transcriptional Adaptations Improve Physical Performance of Zebrafish. Antioxidants (Basel, Switzerland). 10(10):

Qi, H., Schmöhl, F., Li, X., Qian, X., Tabler, C.T., Bennewitz, K., Sticht, C., Morgenstern, J., Fleming, T., Volk, N., Hausser, I., Heidenreich, E., Hell, R., Nawroth, P.P., Kroll, J. (2021) Reduced Acrolein Detoxification in akr1a1a Zebrafish Mutants Causes Impaired Insulin Receptor Signaling and Microvascular Alterations. Advanced science (Weinheim, Baden-Wurttemberg, Germany). 8(18):e2101281

Middel, C.S., Hammes, H.P., Kroll, J. (2021) Advancing Diabetic Retinopathy Research: Analysis of the Neurovascular Unit in Zebrafish. Cells. 10(6):

Li, X., Schmöhl, F., Qi, H., Bennewitz, K., Tabler, C.T., Poschet, G., Hell, R., Volk, N., Poth, T., Hausser, I., Morgenstern, J., Fleming, T., Nawroth, P.P., Kroll, J. (2020) Regulation of Gluconeogenesis by Aldo-keto-reductase 1a1b in Zebrafish. iScience. 23:101763

Lou, B., Boger, M., Bennewitz, K., Sticht, C., Kopf, S., Morgenstern, J., Fleming, T., Hell, R., Yuan, Z., Nawroth, P.P., Kroll, J. (2020) Elevated 4-hydroxynonenal induces hyperglycaemia via Aldh3a1 loss in zebrafish and associates with diabetes progression in humans. Redox Biology. 37:101723

Wiggenhauser, L.M., Qi, H., Stoll, S.J., Metzger, L., Bennewitz, K., Poschet, G., Krenning, G., Hillebrands, J.L., Hammes, H.P., Kroll, J. (2020) Activation of retinal angiogenesis in hyperglycemic pdx1^-/- zebrafish mutants. Diabetes. 69(5):1020-1031

She, J., Wu, Y., Lou, B., Lodd, E., Klems, A., Schmoehl, F., Yuan, Z., Noble, F.L., Kroll, J. (2019) Genetic compensation by epob in pronephros development in epoa mutant zebrafish. Cell cycle (Georgetown, Tex.). 18(20):2683-2696

Lodd, E., Wiggenhauser, L.M., Morgenstern, J., Fleming, T.H., Poschet, G., Büttner, M., Tabler, C.T., Wohlfart, D.P., Nawroth, P.P., Kroll, J. (2019) The combination of loss of glyoxalase1 and obesity results in hyperglycemia. JCI insight. 4(12):

Schmöhl, F., Peters, V., Schmitt, C.P., Poschet, G., Büttner, M., Li, X., Weigand, T., Poth, T., Volk, N., Morgenstern, J., Fleming, T., Nawroth, P.P., Kroll, J. (2019) CNDP1 knockout in zebrafish alters the amino acid metabolism, restrains weight gain, but does not protect from diabetic complications. Cellular and molecular life sciences : CMLS. 76(22):4551-4568

Wiggenhauser, L.M., Kroll, J. (2018) Vascular damage in obesity and diabetes: Highlighting links between endothelial dysfunction and metabolic disease in zebrafish and man. Current vascular pharmacology. 17(5):476-490

Sturtzel, C., Lipnik, K., Hofer-Warbinek, R., Testori, J., Ebner, B., Seigner, J., Qiu, P., Bilban, M., Jandrositz, A., Preisegger, K.H., Untergasser, G., Gunsilius, E., de Martin, R., Kroll, J., Hofer, E. (2018) FOXF1 Mediates Endothelial Progenitor Functions and Regulates Vascular Sprouting. Frontiers in bioengineering and biotechnology. 6:76

Hitzel, J., Lee, E., Zhang, Y., Bibli, S.I., Li, X., Zukunft, S., Pflüger, B., Hu, J., Schürmann, C., Vasconez, A.E., Oo, J.A., Kratzer, A., Kumar, S., Rezende, F., Josipovic, I., Thomas, D., Giral, H., Schreiber, Y., Geisslinger, G., Fork, C., Yang, X., Sigala, F., Romanoski, C.E., Kroll, J., Jo, H., Landmesser, U., Lusis, A.J., Namgaladze, D., Fleming, I., Leisegang, M.S., Zhu, J., Brandes, R.P. (2018) Oxidized phospholipids regulate amino acid metabolism through MTHFD2 to facilitate nucleotide release in endothelial cells. Nature communications. 9:2292

Wiggenhauser, L.M., Kohl, K., Dietrich, N., Hammes, H.P., Kroll, J. (2017) Studying Diabetes Through the Eyes of a Fish: Microdissection, Visualization, and Analysis of the Adult tg(fli:EGFP) Zebrafish Retinal Vasculature. Journal of visualized experiments : JoVE. (130)

She, J., Yuan, Z., Wu, Y., Chen, J., Kroll, J. (2017) Targeting erythropoietin protects against proteinuria in type 2 diabetic patients and in zebrafish. Molecular metabolism. 8:189-202

Heckler, K., Kroll, J. (2017) Zebrafish as a Model for the Study of Microvascular Complications of Diabetes and Their Mechanisms. International Journal of Molecular Sciences. 18(9)

Sharma, K.R., Heckler, K., Stoll, S.J., Hillebrands, J.L., Kynast, K., Herpel, E., Porubsky, S., Elger, M., Hadaschik, B., Bieback, K., Hammes, H.P., Nawroth, P.P., Kroll, J. (2016) ELMO1 protects renal structure and ultrafiltration in kidney development and under diabetic conditions. Scientific Reports. 6:37172

Kiesow, K., Bennewitz, K., Miranda, L.G., Stoll, S.J., Hartenstein, B., Angel, P., Kroll, J., Schorpp-Kistner, M. (2015) Junb controls lymphatic vascular development in zebrafish via miR-182. Scientific Reports. 5:15007

Schaeker, K., Bartsch, S., Patry, C., Cramer-Stoll, S., Hillebrands, J.L., Wieland, T., Kroll, J. (2015) The bipartite Rac1 guanine nucleotide exchange factor engulfment and cell motility 1/dedicator of cytokinesis 180 (Elmo1/Dock180) protects endothelial cells from apoptosis in blood vessel development. The Journal of biological chemistry. 290(10):6408-18

Jörgens, K., Stoll, S.J., Pohl, J., Fleming, T.H., Sticht, C., Nawroth, P.P., Hammes, H.P., Kroll, J. (2015) High tissue glucose alters intersomitic blood vessels in zebrafish via methylglyoxal targeting the VEGF receptor signalling cascade. Diabetes. 64(1):213-25

Feng, Y., Gross, S., Wolf, N.M., Butenschön, V.M., Qiu, Y., Devraj, K., Liebner, S., Kroll, J., Skolnik, E.Y., Hammes, H.P., Wieland, T. (2014) Nucleoside Diphosphate Kinase B Regulates Angiogenesis Through Modulation of Vascular Endothelial Growth Factor Receptor Type 2 and Endothelial Adherens Junction Proteins. Arterioscler. Thromb. Vasc. Biol.. 34(10):2292-300

Manavski, Y., Carmona, G., Bennewitz, K., Tang, Z., Zhang, F., Sakurai, A., Zeiher, A.M., Gutkind, J.S., Li, X., Kroll, J., Dimmeler, S., and Chavakis, E. (2014) Brag2 differentially regulates beta1- and beta3-integrin-dependent adhesion in endothelial cells and is involved in developmental and pathological angiogenesis. Basic Research in Cardiology. 109(2):404

Hollenbach, M., Stoll, S.J., Jörgens, K., Seufferlein, T., and Kroll, J. (2013) Different Regulation of Physiological and Tumor Angiogenesis in Zebrafish by Protein Kinase D1 (PKD1). PLoS One. 8(7):e68033

Kaluza, D., Kroll, J., Gesierich, S., Manavski, Y., Boeckel, J., Doebele, C., Zelent, A., Rossig, L., Zeiher, A. M., Augustin, H. G., Urbich, C., Dimmeler, S. (2013) Histone deacetylase 9 promotes angiogenesis by targeting the antiangiogenic microRNA-17-92 cluster in endothelial cells.. Arteriosclerosis, Thrombosis, and Vascular Biology. 33:533-543

Stoll, S.J., Bartsch, S., and Kroll, J. (2013) HOXC9 Regulates Formation of Parachordal Lymphangioplasts and the Thoracic Duct in Zebrafish via Stabilin 2. PLoS One. 8(3):e58311

Hassel, D., Cheng, P., White, M.P., Ivey, K.N., Kroll, J., Augustin, H.G., Katus, H.A., Stainier, D.Y., and Srivastava, D. (2012) MicroRNA-10 Regulates the Angiogenic Behavior of Zebrafish and Human Endothelial Cells by Promoting Vascular Endothelial Growth Factor Signaling. Circulation research. 111(11):1421-1433

Jörgens, K., Hillebrands, J.L., Hammes, H.P., and Kroll, J. (2012) Zebrafish: A Model for Understanding Diabetic Complications. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association. 120(4):186-187

Urbich, C., Kaluza, D., Frömel, T., Knau, A., Bennewitz, K., Boon, R.A., Bonauer, A., Doebele, C., Boeckel, J.N., Hergenreider, E., Zeiher, A.M., Kroll, J., Fleming, I., and Dimmeler, S. (2012) MicroRNA-27a/b controls endothelial cell repulsion and angiogenesis by targeting semaphorin 6A. Blood. 119(6):1607-1616

Jörgens, K., Schäker, K., and Kroll, J. (2011) The model organism zebrafish in biomedical research: applications and perspectives in vascular biology and medicine. Deutsche medizinische Wochenschrift (1946). 136(37):1865-1868

Kaluza, D., Kroll, J., Gesierich, S., Yao, T.P., Boon, R.A., Hergenreider, E., Tjwa, M., Rössig, L., Seto, E., Augustin, H.G., Zeiher, A.M., Dimmeler, S., and Urbich, C. (2011) Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. The EMBO journal. 30(20):4142-56

Stoll, S.J., Bartsch, S., Augustin, H.G., and Kroll, J. (2011) The Transcription Factor HOXC9 Regulates Endothelial Cell Quiescence and Vascular Morphogenesis in Zebrafish via Inhibition of Interleukin 8. Circulation research. 108:1367-1377

Epting, D., Wendik, B., Bennewitz, K., Dietz, C.T., Driever, W., and Kroll, J. (2010) The Rac1 Regulator ELMO1 Controls Vascular Morphogenesis in Zebrafish. Circulation research. 107(1):45-55