Lab
Kurrasch Lab
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Statement of Research Interest
Statement of Research Interests: The Kurrasch lab studies the genetic programs that govern hypothalamic development. We are interested in cell fate decisions as well as neuronal migration mechanisms that cause neurons to coalesce into a nucleus. In addition, we examine how environmental challenges (e.g., endocrine disrupting chemicals, toxicants) perturb normal development of this region.
Lab Members
| Ibhazehiebo, Kingsley Post-Doc | Zhang, Zi Wei Post-Doc | Kinch, Cassandra Graduate Student |
| Obasuyi, Osahon Graduate Student | Kaushik, Gaurav Research Staff | Rehak, Renata Research Staff |
| Vandenbrink, Alicia Administrative Staff |
- Dogra, D., Meza-Santoscoy, P.L., Gavrilovici, C., Rehak, R., de la Hoz, C.L.R., Ibhazehiebo, K., Rho, J.M., Kurrasch, D.M. (2023) kcna1a mutant zebrafish model episodic ataxia type 1 (EA1) with epilepsy and respond to first-line therapy carbamazepine. Epilepsia. 64(8):2186-2199
- Lessey, A.J., Mirczuk, S.M., Chand, A.N., Kurrasch, D.M., Korbonits, M., Niessen, S.J.M., McArdle, C.A., McGonnell, I.M., Fowkes, R.C. (2023) Pharmacological and Genetic Disruption of C-Type Natriuretic Peptide (nppcl) Expression in Zebrafish (Danio rerio) Causes Stunted Growth during Development. International Journal of Molecular Sciences. 24(16):
- Ibhazehiebo, K., Rho, J.M., Kurrasch, D.M. (2020) Metabolism-based drug discovery in zebrafish: An emerging strategy to uncover new anti-seizure therapies. Neuropharmacology. 167:107988
- Ibhazehiebo, K., Gavrilovici, C., de la Hoz, C.L., Ma, S.C., Rehak, R., Kaushik, G., Meza Santoscoy, P.L., Scott, L., Nath, N., Kim, D.Y., Rho, J.M., Kurrasch, D.M. (2018) A novel metabolism-based phenotypic drug discovery platform in zebrafish uncovers HDACs 1 and 3 as a potential combined anti-seizure drug target. Brain : a journal of neurology. 141(3):744-761
- Best, C., Kurrasch, D.M., Vijayan, M.M. (2017) Maternal cortisol stimulates neurogenesis and affects larval behaviour in zebrafish. Scientific Reports. 7:40905
- Nesan, D., Sewell, L.C., Kurrasch, D.M. (2017) Opening the black box of endocrine disruption of brain development: Lessons from the characterization of Bisphenol A. Hormones and behavior. 101:50-58
- Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63
- Kinch, C.D., Kurrasch, D.M., Habibi, H.R. (2016) Adverse morphological development in embryonic zebrafish exposed to environmental concentrations of contaminants individually and in mixture. Aquatic toxicology (Amsterdam, Netherlands). 175:286-298
- Kinch, C.D., Ibhazehiebo, K., Jeong, J.H., Habibi, H.R., Kurrasch, D.M. (2015) Low-dose exposure to bisphenol A and replacement bisphenol S induces precocious hypothalamic neurogenesis in embryonic zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 112(5):1475-80
- Kurrasch, D.M., Nevin, L.M., Wong, J., Baier, H., and Ingraham, H.A. (2009) Neuroendocrine transcriptional programs adapt dynamically to the supply and demand for neuropeptides as revealed in NSF mutant zebrafish. Neural Development. 4:22
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