Lab
Lowe Lab
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Statement of Research Interest
The Lowe Lab studies membrane traffic in the secretory and endocytic pathways. A major interest is the structure and function of the Golgi apparatus. We also study the lipid phosphatase OCRL1, which is mutated in Lowe syndrome and Dent-2 disease, and which plays an important role in endocytic trafficking. We use a combination of mammalian cell culture and zebrafish as experimental systems to carry out this work.
Lab Members
| Sato, Keisuke Post-Doc | Mehta, Zenobia Graduate Student | Oltrabella, Francesca Graduate Student |
| Pietka, Grzegorz Graduate Student | Yan, Guanhua Technical Staff |
- Naylor, R.W., Lemarie, E., Jackson-Crawford, A., Davenport, J.B., Mironov, A., Lowe, M., Lennon, R. (2024) Corrigendum to "A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish." Kidney Int. 2022;102:815-827. Kidney International. 105:214215214-215
- Issler, N., Afonso, S., Weissman, I., Jordan, K., Cebrian-Serrano, A., Meindl, K., Dahlke, E., Tziridis, K., Yan, G., Robles-López, J.M., Tabernero, L., Patel, V., Kesselheim, A., Klootwijk, E.D., Stanescu, H.C., Dumitriu, S., Iancu, D., Tekman, M., Mozere, M., Jaureguiberry, G., Outtandy, P., Russell, C., Forst, A.L., Sterner, C., Heinl, E.S., Othmen, H., Tegtmeier, I., Reichold, M., Schiessl, I.M., Limm, K., Oefner, P., Witzgall, R., Fu, L., Theilig, F., Schilling, A., Shuster Biton, E., Kalfon, L., Fedida, A., Arnon-Sheleg, E., Ben Izhak, O., Magen, D., Anikster, Y., Schulze, H., Ziegler, C., Lowe, M., Davies, B., Böckenhauer, D., Kleta, R., Falik Zaccai, T.C., Warth, R. (2022) A Founder Mutation in EHD1 Presents with Tubular Proteinuria and Deafness. Journal of the American Society of Nephrology : JASN. 33(4):732-745
- Morgan, J., Yarwood, R., Starborg, T., Yan, G., Lowe, M. (2022) Pacsin2 is required for endocytosis in the zebrafish pronephric tubule. Biology Open. 11(6):
- Naylor, R.W., Lemarie, E., Jackson-Crawford, A., Davenport, J.B., Mironov, A., Lowe, M., Lennon, R. (2022) A novel nanoluciferase transgenic reporter measures proteinuria in zebrafish. Kidney International. 102(4):815-827
- Naylor, R.W., Watson, E., Williamson, S., Preston, R., Davenport, J.B., Thornton, N., Lowe, M., Williams, M., Lennon, R. (2022) Basement membrane defects in CD151-associated glomerular disease. Pediatric nephrology (Berlin, Germany). 37(12):3105-3115
- Williams, D.M., Gungordu, L., Jackson-Crawford, A., Lowe, M. (2022) Assessment of endocytic traffic and Ocrl function in the developing zebrafish neuroepithelium. Journal of Cell Science. 135(18)
- Oltrabella, F., Jackson-Crawford, A., Yan, G., Rixham, S., Starborg, T., Lowe, M. (2021) IPIP27A cooperates with OCRL to support endocytic traffic in the zebrafish pronephric tubule. Human molecular genetics. 31(8):1183-1196
- De Leo, E., Elmonem, M.A., Berlingerio, S.P., Berquez, M., Festa, B.P., Raso, R., Bellomo, F., Starborg, T., Janssen, M.J., Abbaszadeh, Z., Cairoli, S., Goffredo, B.M., Masereeuw, R., Devuyst, O., Lowe, M., Levtchenko, E., Luciani, A., Emma, F., Rega, L.R. (2020) Cell-Based Phenotypic Drug Screening Identifies Luteolin as Candidate Therapeutic for Nephropathic Cystinosis. Journal of the American Society of Nephrology : JASN. 31(7):1522-1537
- Bruning, J.M., Wang, Y., Oltrabella, F., Tian, B., Kholodar, S.A., Liu, H., Bhattacharya, P., Guo, S., Holton, J.M., Fletterick, R.J., Jacobson, M.P., England, P.M. (2019) Covalent Modification and Regulation of the Nuclear Receptor Nurr1 by a Dopamine Metabolite. Cell chemical biology. 26(5):674-685.e6
- Mondin, V.E., Ben El Kadhi, K., Cauvin, C., Jackson-Crawford, A., Bélanger, E., Decelle, B., Salomon, R., Lowe, M., Echard, A., Carréno, S. (2019) PTEN reduces endosomal PtdIns(4,5)P2 in a phosphatase-independent manner via a PLC pathway. The Journal of cell biology. 218(7):2198-2214
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