ZFIN ID: ZDB-LAB-101014-1
Kasher Lab
PI/Director: Kasher, Paul
Contact Person: Kasher, Paul
Email: paul.kasher@manchester.ac.uk
URL:
Address: Division of Neuroscience & Experimental Psychology, AV Hill Building The University of Manchester Oxford Road Manchester M13 9PT
Country: United Kingdom
Phone: +44 161 3068059
Fax:
Line Designation: umc


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 2 genomic features


STATEMENT OF RESEARCH INTERESTS


LAB MEMBERS


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Withers, S.E., Rowlands, C.F., Tapia, V.S., Hedley, F., Mosneag, I.E., Crilly, S., Rice, G.I., Badrock, A.P., Hayes, A., Allan, S.M., Briggs, T.A., Kasher, P.R. (2023) Characterization of a mutant samhd1 zebrafish model implicates dysregulation of cholesterol biosynthesis in Aicardi-Goutières syndrome. Frontiers in immunology. 14:11009671100967
Crilly, S., Parry-Jones, A., Wang, X., Selley, J.N., Cook, J., Tapia, V.S., Anderson, C.S., Allan, S.M., Kasher, P.R. (2022) Zebrafish drug screening identifies candidate therapies for neuroprotection after spontaneous intracerebral haemorrhage. Disease models & mechanisms. 15(3):
Crilly, S., Cooper, J., Bradford, L., Prise, I.E., Krishnan, S., Kasher, P.R. (2021) RNA-Seq Dataset From Isolated Leukocytes Following Spontaneous Intracerebral Hemorrhage in Zebrafish Larvae. Frontiers in Cellular Neuroscience. 15:660732
Faundes, V., Jennings, M.D., Crilly, S., Legraie, S., Withers, S.E., Cuvertino, S., Davies, S.J., Douglas, A.G.L., Fry, A.E., Harrison, V., Amiel, J., Lehalle, D., Newman, W.G., Newkirk, P., Ranells, J., Splitt, M., Cross, L.A., Saunders, C.J., Sullivan, B.R., Granadillo, J.L., Gordon, C.T., Kasher, P.R., Pavitt, G.D., Banka, S. (2021) Impaired eIF5A function causes a Mendelian disorder that is partially rescued in model systems by spermidine. Nature communications. 12:833
Rutherford, H.A., Kasher, P.R., Hamilton, N. (2021) Dirty Fish Versus Squeaky Clean Mice: Dissecting Interspecies Differences Between Animal Models of Interferonopathy. Frontiers in immunology. 11:623650
Badrock, A.P., Uggenti, C., Wacheul, L., Crilly, S., Jenkinson, E.M., Rice, G.I., Kasher, P.R., Lafontaine, D.L.J., Crow, Y.J., O'Keefe, R.T. (2020) Analysis of U8 snoRNA Variants in Zebrafish Reveals How Bi-allelic Variants Cause Leukoencephalopathy with Calcifications and Cysts. American journal of human genetics. 106(5):694-706
Crilly, S., Njegic, A., Parry-Jones, A.R., Allan, S.M., Kasher, P.R. (2019) Using Zebrafish Larvae to Study the Pathological Consequences of Hemorrhagic Stroke. Journal of visualized experiments : JoVE. (148)
Crilly, S., Njegic, A., Laurie, S.E., Fotiou, E., Hudson, G., Barrington, J., Webb, K., Young, H.L., Badrock, A.P., Hurlstone, A., Rivers-Auty, J., Parry-Jones, A.R., Allan, S.M., Kasher, P.R. (2018) Using zebrafish larval models to study brain injury, locomotor and neuroinflammatory outcomes following intracerebral haemorrhage. F1000Research. 7:1617
Kasher, P.R., Schertz, K.E., Thomas, M., Jackson, A., Annunziata, S., Ballesta-Martinez, M.J., Campeau, P.M., Clayton, P.E., Eaton, J.L., Granata, T., Guillén-Navarro, E., Hernando, C., Laverriere, C.E., Liedén, A., Villa-Marcos, O., McEntagart, M., Nordgren, A., Pantaleoni, C., Pebrel-Richard, C., Sarret, C., Sciacca, F.L., Wright, R., Kerr, B., Glasgow, E., Banka, S. (2016) Small 6q16.1 Deletions Encompassing POU3F2 Cause Susceptibility to Obesity and Variable Developmental Delay with Intellectual Disability. American journal of human genetics. 98(2):363-72
Kasher, P.R., Jenkinson, E.M., Briolat, V., Gent, D., Morrissey, C., Zeef, L.A., Rice, G.I., Levraud, J.P., Crow, Y.J. (2015) Characterization of samhd1 Morphant Zebrafish Recapitulates Features of the Human Type I Interferonopathy Aicardi-Goutières Syndrome. Journal of immunology (Baltimore, Md. : 1950). 194(6):2819-25
Schaffer, A.E., Eggens, V.R., Caglayan, A.O., Reuter, M.S., Scott, E., Coufal, N.G., Silhavy, J.L., Xue, Y., Kayserili, H., Yasuno, K., Rosti, R.O., Abdellateef, M., Caglar, C., Kasher, P.R., Cazemier, J.L., Weterman, M.A., Cantagrel, V., Cai, N., Zweier, C., Altunoglu, U., Satkin, N.B., Aktar, F., Tuysuz, B., Yalcinkaya, C., Caksen, H., Bilguvar, K., Fu, X.D., Trotta, C.R., Gabriel, S., Reis, A., Gunel, M., Baas, F., Gleeson, J.G. (2014) CLP1 Founder Mutation Links tRNA Splicing and Maturation to Cerebellar Development and Neurodegeneration. Cell. 157:651-63
Weterman, M.A., Sorrentino, V., Kasher, P.R., Jakobs, M.E., van Engelen, B.G., Fluiter, K., de Wissel, M.B., Sizarov, A., Nürnberg, G., Nürnberg, P., Zelcer, N., Schelhaas, H.J., and Baas, F. (2012) A frameshift mutation in LRSAM1 is responsible for a dominant hereditary polyneuropathy. Human molecular genetics. 21(2):358-70
Kasher, P.R., Namavar, Y., van Tijn, P., Fluiter, K., Sizarov, A., Kamermans, M., Grierson, A.J., Zivkovic, D., and Baas, F. (2011) Impairment of the tRNA splicing endonuclease subunit 54 (tsen54) gene causes neurological abnormalities and larval death in zebrafish models of Pontocerebellar Hypoplasia. Human molecular genetics. 20(8):1574-84