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Research
General Information
ZIRC
ZFIN ID: ZDB-LAB-100915-3
Hyunsook Lee Lab
PI/Director: Lee, Hyunsook
Contact Person: Jeong, Kilhoon
Email: love03@hanmail.net
URL: http://plaza.snu.ac.kr/~hyunlee/
Address: School of Biological Sciences Seoul National University Institute of Molecular Biology and Genetics (Building No.105) Room No.306 San 56-1 Shilim-dong Kwanak-ku Seoul Korea
Country: South Korea
Phone: +82-2-886-4339
Fax: +82-2-886-4335
Line Designation: snu


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show all 1 genomic features


STATEMENT OF RESEARCH INTERESTS
We are interested in the mechanism of initiation and progression of cancer; the molecular mechanism underlying chromosome instability. Multiple systems are used in our laboratory to depending on the specific questions chosen by the lab members: first, we utilize cultured human cell lines for identifying detailed mechanisms using biochemical & cell biological methods; we make mutant mice based on the mechanism we built to understand the physiological cosequence and also to confirm the results in vivo; for visualizing chromosome segregation and study mitosis at the organismal level, we use zebrafish. In summary we try to understand the basis of genetic instability of cancer using multiple systems; cell lines, mouse, and zebrafish. Specific questions are listed below.
1. Chromosome instability in BRCA2-deficient mice
2. Regulatory Mechanisms of BubR1 Spindle assembly checkpoint
3. Understanding mitosis using zebrafish as a model organism
4. Visualizing mitosis in mice (Knockout, Knock-in and transgenic mice) and zebrafish


LAB MEMBERS
Choi, Eunhee Post-Doc Kwon, Misun Post-Doc Cho, Byuri Graduate Student
Choe, Hyerim Graduate Student Hwang, KwangWoo Graduate Student Jeon, Hee-Yeon Graduate Student
Jeong, Jun-hyeon Graduate Student Jeong, Kilhoon Graduate Student Kang, Julki Graduate Student
Ko, Eunkyong Graduate Student Lee, Yookyung Graduate Student Min, Jaewon Graduate Student
Park, Pil-gu Graduate Student Seong, Junho Graduate Student Yi, Seonju Graduate Student


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS x
Chang, H., Yeo, J., Kim, J.G., Kim, H., Lim, J., Lee, M., Kim, H.H., Ohk, J., Jeon, H.Y., Lee, H., Jung, H., Kim, K.W., Kim, V.N. (2018) Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos. Molecular Cell. 70:72-82.e7
Jeon, H.Y., and Lee, H. (2013) Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. The FEBS journal. 280(6):1518-1530
Jeong, K., Jeong, J.Y., Lee, H.O., Choi, E., and Lee, H. (2010) Inhibition of Plk1 induces mitotic infidelity and embryonic growth defects in developing zebrafish embryos. Developmental Biology. 345(1):34-48
Lee, H.O., Choe, H., Seo, K., Lee, H., Lee, J., and Kim, J. (2010) Fgfbp1 is essential for the cellular survival during zebrafish embryogenesis. Molecules and cells. 29(5):501-507
Lee, H. and Kimelman, D. (2002) A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Developmental Cell. 2(5):607-616