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ZFIN ID: ZDB-LAB-100915-3
Hyunsook Lee Lab
PI/Director: Lee, Hyunsook
Contact Person: Jeong, Kilhoon
Address: School of Biological Sciences Seoul National University Institute of Molecular Biology and Genetics (Building No.105) Room No.306 San 56-1 Shilim-dong Kwanak-ku Seoul Korea
Country: South Korea
Phone: +82-2-886-4339
Fax: +82-2-886-4335
Line Designation: snu

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We are interested in the mechanism of initiation and progression of cancer; the molecular mechanism underlying chromosome instability. Multiple systems are used in our laboratory to depending on the specific questions chosen by the lab members: first, we utilize cultured human cell lines for identifying detailed mechanisms using biochemical & cell biological methods; we make mutant mice based on the mechanism we built to understand the physiological cosequence and also to confirm the results in vivo; for visualizing chromosome segregation and study mitosis at the organismal level, we use zebrafish. In summary we try to understand the basis of genetic instability of cancer using multiple systems; cell lines, mouse, and zebrafish. Specific questions are listed below.
1. Chromosome instability in BRCA2-deficient mice
2. Regulatory Mechanisms of BubR1 Spindle assembly checkpoint
3. Understanding mitosis using zebrafish as a model organism
4. Visualizing mitosis in mice (Knockout, Knock-in and transgenic mice) and zebrafish

Choi, Eunhee Post-Doc Kwon, Misun Post-Doc Cho, Byuri Graduate Student
Choe, Hyerim Graduate Student Hwang, KwangWoo Graduate Student Jeon, Hee-Yeon Graduate Student
Jeong, Jun-hyeon Graduate Student Jeong, Kilhoon Graduate Student Kang, Julki Graduate Student
Ko, Eunkyong Graduate Student Lee, Yookyung Graduate Student Min, Jaewon Graduate Student
Park, Pil-gu Graduate Student Seong, Junho Graduate Student Yi, Seonju Graduate Student

Chang, H., Yeo, J., Kim, J.G., Kim, H., Lim, J., Lee, M., Kim, H.H., Ohk, J., Jeon, H.Y., Lee, H., Jung, H., Kim, K.W., Kim, V.N. (2018) Terminal Uridylyltransferases Execute Programmed Clearance of Maternal Transcriptome in Vertebrate Embryos. Molecular Cell. 70:72-82.e7
Jeon, H.Y., and Lee, H. (2013) Depletion of Aurora-A in zebrafish causes growth retardation due to mitotic delay and p53-dependent cell death. The FEBS journal. 280(6):1518-1530
Jeong, K., Jeong, J.Y., Lee, H.O., Choi, E., and Lee, H. (2010) Inhibition of Plk1 induces mitotic infidelity and embryonic growth defects in developing zebrafish embryos. Developmental Biology. 345(1):34-48
Lee, H.O., Choe, H., Seo, K., Lee, H., Lee, J., and Kim, J. (2010) Fgfbp1 is essential for the cellular survival during zebrafish embryogenesis. Molecules and cells. 29(5):501-507
Lee, H. and Kimelman, D. (2002) A dominant-negative form of p63 is required for epidermal proliferation in zebrafish. Developmental Cell. 2(5):607-616