Lab
Lila Solnica-Krezel lab
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Statement of Research Interest
During embryonic development of a vertebrate embryo a series of inductive interactions and cellular rearrangements of gastrulation establishes a blueprint of the body plan. Our laboratory is studying cellular and molecular mechanisms underlying gastrulation with an emphasis on interrelationships between the inductive and morphogenetic events.
Lab Members
| Li, Linwei Post-Doc | Vedder, Viviana Post-Doc | Hindes, Anna Research Staff |
| McAdow, Ryan Research Staff | Sepich, Diane Research Staff | Shin, Jimann Research Staff |
| Yoon, Eun-Ja Research Staff | Brush, Jacob | Randall, Alvin |
- Kohler, J.N., Legro, N.R., Baldridge, D., Shin, J., Bowman, A., Ugur, B., Jackstadt, M.M., Shriver, L.P., Patti, G.J., Zhang, B., Feng, W., McAdow, A.R., Goddard, P., Ungar, R.A., Jensen, T., Smith, K.S., Fresard, L., Alvarez, R., Bonner, D., Reuter, C.M., McCormack, C., Kravets, E., Marwaha, S., Holt, J.M., Undiagnosed Diseases Network, Worthey, E., Ashley, E.A., Montgomery, S.B., Fisher, P., Postlethwait, J., De Camilli, P., Solnica-Krezel, L., Bernstein, J.A., Wheeler, M.T. (2024) Loss of function of FAM177A1, a Golgi complex localized protein, causes a novel neurodevelopmental disorder. Genetics in medicine : official journal of the American College of Medical Genetics. 26(9):101166
- Lee, J., Goeckel, M.E., Levitas, A., Colijn, S., Shin, J., Hindes, A., Mun, G., Burton, Z., Chintalapati, B., Yin, Y., Abello, J., Solnica-Krezel, L., Stratman, A. (2024) CXCR3-CXCL11 Signaling Restricts Angiogenesis and Promotes Pericyte Recruitment. Arteriosclerosis, Thrombosis, and Vascular Biology. 44(12):2577-2595
- Ugur, B., Schueder, F., Shin, J., Hanna, M.G., Wu, Y., Leonzino, M., Su, M., McAdow, A.R., Wilson, C., Postlethwait, J., Solnica-Krezel, L., Bewersdorf, J., De Camilli, P. (2024) VPS13B is localized at the interface between Golgi cisternae and is a functional partner of FAM177A1. The Journal of cell biology. 223(12):
- Kamimoto, K., Stringa, B., Hoffmann, C.M., Jindal, K., Solnica-Krezel, L., Morris, S.A. (2023) Dissecting cell identity via network inference and in silico gene perturbation. Nature. 614(7949):742-751
- Leid, J., Gray, R., Rakita, P., Koenig, A.L., Tripathy, R., Fitzpatrick, J.A.J., Kaufman, C., Solnica-Krezel, L., Lavine, K.J. (2023) Deletion of taf1 and taf5 in zebrafish capitulate cardiac and craniofacial abnormalities associated with TAFopathies through perturbations in metabolism. Biology Open. 12(7):
- Vedder, V.L., Reinberger, T., Haider, S.M.I., Eichelmann, L., Odenthal, N., Abdelilah-Seyfried, S., Aherrahrou, Z., Breuer, M., Erdmann, J. (2023) pyHeart4Fish: Chamber-specific heart phenotype quantification of zebrafish in high-content screens. Frontiers in cell and developmental biology. 11:11438521143852
- Stark, B.C., Gao, Y., Sepich, D.S., Belk, L., Culver, M.A., Hu, B., Mekel, M., Ferris, W., Shin, J., Solnica-Krezel, L., Lin, F., Cooper, J.A. (2021) CARMIL3 is important for cell migration and morphogenesis during early development in zebrafish. Developmental Biology. 481:148-159
- Budine, T.E., de Sena-Tomás, C., Williams, M.L.K., Sepich, D.S., Targoff, K.L., Solnica-Kreze, L. (2020) Gon4l/Udu Regulates Cardiomyocyte Proliferation and Maintenance of Ventricular Chamber Identity During Zebrafish Development. Developmental Biology. 462(2):223-234
- Gray, R.S., Gonzalez, R., Ackerman, S.D., Minowa, R., Griest, J.F., Bayrak, M.N., Troutwine, B., Canter, S., Monk, K.R., Sepich, D.S., Solnica-Krezel, L. (2020) Postembryonic screen for mutations affecting spine development in zebrafish. Developmental Biology. 471:18-33
- Troutwine, B.R., Gontarz, P., Konjikusic, M.J., Minowa, R., Monstad-Rios, A., Sepich, D.S., Kwon, R.Y., Solnica-Krezel, L., Gray, R.S. (2020) The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine. Current biology : CB. 30(12):2353-2362.e3
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