ZFIN ID: ZDB-LAB-100609-1
Lila Solnica-Krezel lab –
PI/Director: Solnica-Krezel, Lilianna
Contact Person: Hindes, Anna
Email: ahindes@wustl.edu
URL: https://lsklab.wustl.edu/
Address: Department of Developmental Biology Washington University School of Medicine 4523 Clayton Avenue St. Louis, MO 63110 USA
Country: United States
Phone: (314) 362-9398
Fax: (314) 362-7058
Line Designation: stl


GENOMIC FEATURES ORIGINATING FROM THIS LAB
Show first 50 of 56 genomic features


STATEMENT OF RESEARCH INTERESTS
During embryonic development of a vertebrate embryo a series of inductive interactions and cellular rearrangements of gastrulation establishes a blueprint of the body plan. Our laboratory is studying cellular and molecular mechanisms underlying gastrulation with an emphasis on interrelationships between the inductive and morphogenetic events.


LAB MEMBERS
Chen, Jiakun Post-Doc Gray, Ryan Post-Doc Roszko, Isabelle Post-Doc
Budine, Terin Graduate Student Castelvecchi, Gina Graduate Student Liu, Yinzi Graduate Student
Canter, Stephen Research Staff Engelhard, John Research Staff Foege, Johanna Research Staff
Hindes, Anna Research Staff Sepich, Diane Research Staff Shin, Jimann Research Staff


ZEBRAFISH PUBLICATIONS OF LAB MEMBERS
Terhune, E.A., Cuevas, M.T., Monley, A.M., Wethey, C.I., Chen, X., Cattel, M.V., Bayrak, M.N., Bland, M.R., Sutphin, B., Devon Trahan, G., Taylor, M.R.G., Niswander, L.A., Jones, K.L., Baschal, E.E., Antunes, L., Dobbs, M., Gurnett, C., Appel, B., Gray, R., Miller, N.H. (2020) Mutations in KIF7 Implicated in Idiopathic Scoliosis in Humans and Axial Curvatures in Zebrafish. Human Mutation. 42(4):392-407
Gray, R.S., Gonzalez, R., Ackerman, S.D., Minowa, R., Griest, J.F., Bayrak, M.N., Troutwine, B., Canter, S., Monk, K.R., Sepich, D.S., Solnica-Krezel, L. (2020) Postembryonic screen for mutations affecting spine development in zebrafish. Developmental Biology. 471:18-33
Wang, Y., Liu, Z., Yang, G., Gao, Q., Xiao, L., Li, J., Guo, C., Troutwine, B.R., Gray, R.S., Xie, L., Zhang, H. (2020) Coding Variants Coupled With Rapid Modeling in Zebrafish Implicate Dynein Genes, dnaaf1 and zmynd10, as Adolescent Idiopathic Scoliosis Candidate Genes. Frontiers in cell and developmental biology. 8:582255
Bagnat, M., Gray, R.S. (2020) Development of a straight vertebrate body axis. Development (Cambridge, England). 147(21):
Whittle, J., Antunes, L., Harris, M., Upshaw, Z., Sepich, D.S., Johnson, A.N., Mokalled, M., Solnica-Krezel, L., Dobbs, M.B., Gurnett, C.A. (2020) MYH3-associated distal arthrogryposis zebrafish model is normalized with para-aminoblebbistatin. EMBO Molecular Medicine. 12(11):e12356
Troutwine, B.R., Gontarz, P., Konjikusic, M.J., Minowa, R., Monstad-Rios, A., Sepich, D.S., Kwon, R.Y., Solnica-Krezel, L., Gray, R.S. (2020) The Reissner Fiber Is Highly Dynamic In Vivo and Controls Morphogenesis of the Spine. Current biology : CB. 30(12):2353-2362.e3
Williams, M.L.K., Solnica-Krezel, L. (2020) Nodal and Planar Cell Polarity signaling cooperate to regulate zebrafish convergence and extension gastrulation movements. eLIFE. 9:
Budine, T.E., de Sena-Tomás, C., Williams, M.L.K., Sepich, D.S., Targoff, K.L., Solnica-Kreze, L. (2020) Gon4l/Udu Regulates Cardiomyocyte Proliferation and Maintenance of Ventricular Chamber Identity During Zebrafish Development. Developmental Biology. 462(2):223-234
Williams, M.L.K., Solnica-Krezel, L. (2020) Cellular and molecular mechanisms of convergence and extension in zebrafish. Current topics in developmental biology. 136:377-407
Konjikusic, M.J., Yeetong, P., Boswell, C.W., Lee, C., Roberson, E.C., Ittiwut, R., Suphapeetiporn, K., Ciruna, B., Gurnett, C.A., Wallingford, J.B., Shotelersuk, V., Gray, R.S. (2018) Mutations in Kinesin family member 6 reveal specific role in ependymal cell ciliogenesis and human neurological development. PLoS Genetics. 14:e1007817
Haller, G., McCall, K., Jenkitkasemwong, S., Sadler, B., Antunes, L., Nikolov, M., Whittle, J., Upshaw, Z., Shin, J., Baschal, E., Cruchaga, C., Harms, M., Raggio, C., Morcuende, J.A., Giampietro, P., Miller, N.H., Wise, C., Gray, R.S., Solnica-Krezel, L., Knutson, M., Dobbs, M.B., Gurnett, C.A. (2018) A missense variant in SLC39A8 is associated with severe idiopathic scoliosis. Nature communications. 9:4171
Malhotra, D., Shin, J., Solnica-Krezel, L., Raz, E. (2018) Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors. eLIFE. 7
Chen, J., Castelvecchi, G.D., Li-Villarreal, N., Raught, B., Krezel, A.M., McNeill, H., Solnica-Krezel, L. (2018) Atypical Cadherin Dachsous1b Interacts with Ttc28 and Aurora B to Control Microtubule Dynamics in Embryonic Cleavages. Developmental Cell. 45:376-391.e5
Khaliq, M., Ko, S., Liu, Y., Wang, H., Sun, Y., Solnica-Krezel, L., Shin, D. (2018) Stat3 regulates liver progenitor cell-driven liver regeneration in zebrafish. Gene Expression. 18(3):157-170
Williams, M.L.K., Sawada, A., Budine, T., Yin, C., Gontarz, P., Solnica-Krezel, L. (2018) Gon4l regulates notochord boundary formation and cell polarity underlying axis extension by repressing adhesion genes. Nature communications. 9:1319
Herbert, A.L., Fu, M.M., Drerup, C.M., Gray, R.S., Harty, B.L., Ackerman, S.D., O'Reilly-Pol, T., Johnson, S.L., Nechiporuk, A.V., Barres, B.A., Monk, K.R. (2017) Dynein/dynactin is necessary for anterograde transport of Mbp mRNA in oligodendrocytes and for myelination in vivo.. Proceedings of the National Academy of Sciences of the United States of America. 114:E9153-E9162
Chen, J., Xia, L., Bruchas, M.R., Solnica-Krezel, L. (2017) Imaging early embryonic calcium activity with GCaMP6s transgenic zebrafish. Developmental Biology. 430(2):385-396
Sanchez, N.E., Harty, B.L., O'Reilly-Pol, T., Ackerman, S.D., Herbert, A.L., Holmgren, M., Johnson, S.L., Gray, R.S., Monk, K.R. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda). 7(10):3415-3425
Liu, Y., Sepich, D.S., Solnica-Krezel, L. (2017) Stat3/Cdc25a-dependent cell proliferation promotes embryonic axis extension during zebrafish gastrulation. PLoS Genetics. 13:e1006564
Kaiko, G.E., Ryu, S.H., Koues, O.I., Collins, P.L., Solnica-Krezel, L., Pearce, E.J., Pearce, E.L., Oltz, E.M., Stappenbeck, T.S. (2016) The Colonic Crypt Protects Stem Cells from Microbiota-Derived Metabolites. Cell. 165:1708-20
Xie, H., Ye, D., Sepich, D., Lin, F. (2016) S1pr2/Gα13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence. Developmental Biology. 414:228-43
Sepich, D.S., Solnica-Krezel, L. (2016) Intracellular Golgi Complex Organization Reveals Tissue Specific Polarity during Zebrafish Embryogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 245(6):678-91
Nishioka, T., Arima, N., Kano, K., Hama, K., Itai, E., Yukiura, H., Kise, R., Inoue, A., Kim, S.H., Solnica-Krezel, L., Moolenaar, W.H., Chun, J., Aoki, J. (2016) ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation. Scientific Reports. 6:23433
Li-Villarreal, N., Forbes, M.M., Loza, A.J., Chen, J., Ma, T., Helde, K., Moens, C.B., Shin, J., Sawada, A., Hindes, A.E., Dubrulle, J., Schier, A.F., Longmore, G.D., Marlow, F.L., Solnica-Krezel, L. (2015) Dachsous1b cadherin regulates actin and microtubule cytoskeleton during early zebrafish embryogenesis. Development (Cambridge, England). 142(15):2704-18
Roszko, I., Sepich, D., Jessen, J.R., Chandrasekhar, A., Solnica-Krezel, L. (2015) A dynamic intracellular distribution of Vangl2 accompanies cell polarization during zebrafish gastrulation. Development (Cambridge, England). 142(14):2508-20
Dubrulle, J., Jordan, B.M., Akhmetova, L., Farrell, J.A., Kim, S.H., Solnica-Krezel, L., Schier, A.F. (2015) Response to Nodal morphogen gradient is determined by the kinetics of target gene induction. eLIFE. 4
Yang, M.L., Shin, J., Kearns, C.A., Langworthy, M.M., Snell, H., Walker, M.B., Appel, B. (2015) CNS Myelination Requires Cytoplasmic Dynein Function. Developmental dynamics : an official publication of the American Association of Anatomists. 244(2):134-45
Buchan, J.G., Gray, R.S., Gansner, J.M., Alvarado, D.M., Burgert, L., Gitlin, J.D., Gurnett, C.A., Goldsmith, M.I. (2014) Kinesin family member 6 (kif6) is necessary for spine development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 243(12):1646-57
Shin, J., Chen, J., Solnica-Krezel, L. (2014) Efficient homologous recombination-mediated genome engineering in zebrafish using TALE nucleases. Development (Cambridge, England). 141:3807-18
Li, C., Ma, H., Wang, Y., Cao, Z., Graves-Deal, R., Powell, A.E., Starchenko, A., Ayers, G.D., Washington, M.K., Kamath, V., Desai, K., Gerdes, M.J., Solnica-Krezel, L., Coffey, R.J. (2014) Excess PLAC8 promotes an unconventional ERK2-dependent EMT in colon cancer. J. Clin. Invest.. 124(5):2172-87
Gray, R.S., Wilm, T.P., Smith, J., Bagnat, M., Dale, R.M., Topczewski, J., Johnson, S.L., and Solnica-Krezel, L. (2014) Loss of col8a1a function during zebrafish embryogenesis results in congenital vertebral malformations. Developmental Biology. 386(1):72-85
Targoff, K.L., Colombo, S., George, V., Schell, T., Kim, S.H., Solnica-Krezel, L., and Yelon, D. (2013) Nkx genes are essential for maintenance of ventricular identity. Development (Cambridge, England). 140(20):4203-4213
Liu, F., Bhang, S.H., Arentson, E., Sawada, A., Kim, C.K., Kang, I., Yu, J., Sakurai, N., Kim, S.H., Yoo, J.J., Kim, P., Pahng, S.H., Xia, Y., Solnica-Krezel, L., and Choi, K. (2013) Enhanced hemangioblast generation and improved vascular repair and regeneration from embryonic stem cells by defined transcription factors. Stem Cell Reports. 1(2):166-182
Li, X., Roszko, I., Sepich, D.S., Ni, M., Hamm, H.E., Marlow, F.L., and Solnica-Krezel, L. (2013) Gpr125 modulates Dishevelled distribution and planar cell polarity signaling. Development (Cambridge, England). 140(14):3028-3039
Clément, A., Solnica-Krezel, L., and Gould, K.L. (2012) Functional redundancy between Cdc14 phosphatases in zebrafish ciliogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 241(12):1911-1921
Shin, J., Padmanabhan, A., de Groh, E.D., Lee, J.S., Haidar, S., Dahlberg, S., Guo, F., He, S., Wolman, M.A., Granato, M., Lawson, N.D., Wolfe, S.A., Kim, S.H., Solnica-Krezel, L., Kanki, J.P., Ligon, K.L., Epstein, J.A., and Look, A.T. (2012) Zebrafish neurofibromatosis type 1 genes have redundant functions in tumorigenesis and embryonic development. Disease models & mechanisms. 5(6):881-894
Carlin, D., Sepich, D., Grover, V.K., Cooper, M.K., Solnica-Krezel, L., and Inbal, A. (2012) Six3 cooperates with Hedgehog signaling to specify ventral telencephalon by promoting early expression of Foxg1a and repressing Wnt signaling. Development (Cambridge, England). 139(14):2614-2624
Zhu, S., Lee, J.S., Guo, F., Shin, J., Perez-Atayde, A.R., Kutok, J.L., Rodig, S.J., Neuberg, D.S., Helman, D., Feng, H., Stewart, R.A., Wang, W., George, R.E., Kanki, J.P., and Look, A.T. (2012) Activated ALK Collaborates with MYCN in Neuroblastoma Pathogenesis. Cancer Cell. 21(3):362-373
Schepis, A., Sepich, D., and Nelson, W.J. (2012) αE-catenin regulates cell-cell adhesion and membrane blebbing during zebrafish epiboly. Development (Cambridge, England). 139(3):537-46
Wu, S.Y., Shin, J., Sepich, D.S., and Solnica-Krezel, L. (2012) Chemokine GPCR Signaling Inhibits β-Catenin during Zebrafish Axis Formation. PLoS Biology. 10(10):e1001403
Solnica-Krezel, L. and ZFIN Staff (2011) Curation of TILLING Database Links. ZFIN Direct Data Submission.
Zhu, C., Smith, T., McNulty, J., Rayla, A.L., Lakshmanan, A., Siekmann, A.F., Buffardi, M., Meng, X., Shin, J., Padmanabhan, A., Cifuentes, D., Giraldez, A.J., Look, A.T., Epstein, J.A., Lawson, N.D., and Wolfe, S.A. (2011) Evaluation and application of modularly assembled zinc-finger nucleases in zebrafish. Development (Cambridge, England). 138(20):4555-4564
Van Raay, T.J., Fortino, N.J., Miller, B.W., Ma, H., Lau, G., Li, C., Franklin, J.L., Attisano, L., Solnica-Krezel, L., and Coffey, R.J. (2011) Naked1 Antagonizes Wnt Signaling by Preventing Nuclear Accumulation of β-Catenin. PLoS One. 6(4):e18650
Kim, S.H., Speirs, C.K., Solnica-Krezel, L., and Ess, K.C. (2011) Zebrafish model of tuberous sclerosis complex reveals cell-autonomous and non-cell-autonomous functions of mutant tuberin. Disease models & mechanisms. 4(2):255-267
Sepich, D.S., Usmani, M., Pawlicki, S., and Solnica-Krezel, L. (2011) Wnt/PCP signaling controls intracellular position of MTOCs during gastrulation convergence and extension movements. Development (Cambridge, England). 138(3):543-552
Clément, A., Solnica-Krezel, L., and Gould, K.L. (2011) The Cdc14B phosphatase contributes to ciliogenesis in zebrafish. Development (Cambridge, England). 138(2):291-302
Lee, J.S., Padmanabhan, A., Shin, J., Zhu, S., Guo, F., Kanki, J.P., Epstein, J.A., and Look, A.T. (2010) Oligodendrocyte progenitor cell numbers and migration are regulated by the zebrafish orthologs of the NF1 tumor suppressor gene. Human molecular genetics. 19(23):4643-4653
Williams, C., Kim, S.H., Ni, T.T., Mitchell, L., Ro, H., Penn, J.S., Baldwin, S.H., Solnica-Krezel, L., and Zhong, T.P. (2010) Hedgehog signaling induces arterial endothelial cell formation by repressing venous cell fate. Developmental Biology. 341(1):196-204
Hu, T., Li, C., Cao, Z., Van Raay, T.J., Smith, J.G., Willert, K., Solnica-Krezel, L., and Coffey, R.J. (2010) Myristoylated naked2 antagonizes WNT-{beta}-catenin activity by degrading dishevelled-1 at the plasma membrane. The Journal of biological chemistry. 285(18):13561-13568
Sarmah, S., Barrallo-Gimeno, A., Melville, D.B., Topczewski, J., Solnica-Krezel, L., and Knapik, E.W. (2010) Sec24D-dependent transport of extracellular matrix proteins is required for zebrafish skeletal morphogenesis. PLoS One. 5(4):e10367
Calmelet, C., and Sepich, D. (2010) Surface tension and modeling of cellular intercalation during zebrafish gastrulation. Mathematical biosciences and engineering : MBE. 7(2):259-275
Speirs, C.K., Jernigan, K.K., Kim, S.H., Cha, Y.I., Lin, F., Sepich, D.S., DuBois, R.N., Lee, E., and Solnica-Krezel, L. (2010) Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization. Development (Cambridge, England). 137(8):1327-1337
Green, J., Taylor, J.J., Hindes, A., Johnson, S.L., and Goldsmith, M.I. (2009) A gain of function mutation causing skeletal overgrowth in the rapunzel mutant. Developmental Biology. 334(1):224-234
Roszko, I., Sawada, A., and Solnica-Krezel, L. (2009) Regulation of convergence and extension movements during vertebrate gastrulation by the Wnt/PCP pathway. Seminars in cell & developmental biology. 20(8):986-997
Kim, J.D., Chun, H.S., Kim, S.H., Kim, H.S., Kim, Y.S., Kim, M.J., Shin, J., Rhee, M., Yeo, S.Y., and Huh, T.L. (2009) Normal forebrain development may require continual Wnt antagonism until mid-somitogenesis in zebrafish. Biochemical and Biophysical Research Communications. 381(4):717-721
Zeng, X.X., Zheng, X., Xiang, Y., Cho, H.P., Jessen, J.R., Zhong, T.P., Solnica-Krezel, L., and Brown, H.A. (2009) Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish. Developmental Biology. 328(2):363-376
Lin, F., Chen, S., Sepich, D.S., Panizzi, J.R., Clendenon, S.G., Marrs, J.A., Hamm, H.E., and Solnica-Krezel, L. (2009) Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. The Journal of cell biology. 184(6):909-921
Yin, C., Ciruna, B., and Solnica-Krezel, L. (2009) Convergence and extension movements during vertebrate gastrulation. Current topics in developmental biology. 89:163-192
Prober, D.A., Zimmerman, S., Myers, B.R., McDermott, B.M. Jr, Kim, S.H., Caron, S., Rihel, J., Solnica-Krezel, L., Julius, D., Hudspeth, A.J., and Schier, A.F. (2008) Zebrafish TRPA1 channels are required for chemosensation but not for thermosensation or mechanosensory hair cell function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28(40):10102-10110
Geng, X., Speirs, C., Lagutin, O., Inbal, A., Liu, W., Solnica-Krezel, L., Jeong, Y., Epstein, D.J., and Oliver, G. (2008) Haploinsufficiency of Six3 fails to activate Sonic hedgehog expression in the ventral forebrain and causes holoprosencephaly. Developmental Cell. 15(2):236-247
Kim, H., Shin, J., Kim, S., Poling, J., Park, H.C., and Appel, B. (2008) Notch-regulated oligodendrocyte specification from radial glia in the spinal cord of zebrafish embryos. Developmental dynamics : an official publication of the American Association of Anatomists. 237(8):2081-2089
Li, N., Flynt, A.S., Kim, H.R., Solnica-Krezel, L., and Patton, J.G. (2008) Dispatched Homolog 2 is targeted by miR-214 through a combination of three weak microRNA recognition sites. Nucleic acids research. 36(13):4277-4285
Yin, C., Kiskowski, M., Pouille, P.A., Farge, E., and Solnica-Krezel, L. (2008) Cooperation of polarized cell intercalations drives convergence and extension of presomitic mesoderm during zebrafish gastrulation. The Journal of cell biology. 180(1):221-232
Park, H.C., Shin, J., Roberts, R.K., and Appel, B. (2007) An olig2 reporter gene marks oligodendrocyte precursors in the postembryonic spinal cord of zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 236(12):3402-3407
Yin, C., and Solnica-Krezel, L. (2007) Convergence and extension movements affect dynamic notochord-somite interactions essential for zebrafish slow muscle morphogenesis. Developmental dynamics : an official publication of the American Association of Anatomists. 236(10):2742-2756
Van Raay, T.J., Coffey, R.J., and Solnica-Krezel, L. (2007) Zebrafish Naked1 and Naked2 antagonize both canonical and non-canonical Wnt signaling. Developmental Biology. 309(2):151-168
Inbal, A., Kim, S.H., Shin, J., and Solnica-Krezel, L. (2007) Six3 represses nodal activity to establish early brain asymmetry in zebrafish. Neuron. 55(3):407-415
Yang, C.T., Hindes, A.E., Hultman, K.A., and Johnson, S.L. (2007) Mutations in gfpt1 and skiv2l2 Cause Distinct Stage-Specific Defects in Larval Melanocyte Regeneration in Zebrafish. PLoS Genetics. 3(6):e88
Shin, J., Poling, J., Park, H.C., and Appel, B. (2007) Notch signaling regulates neural precursor allocation and binary neuronal fate decisions in zebrafish. Development (Cambridge, England). 134(10):1911-1920
Roszko, I., Faure, P., and Mathis, L. (2007) Stem cell growth becomes predominant while neural plate progenitor pool decreases during spinal cord elongation. Developmental Biology. 304(1):232-245
Yin, C., and Solnica-Krezel, L. (2007) Convergence and extension movements mediate the specification and fate maintenance of zebrafish slow muscle precursors. Developmental Biology. 304(1):141-155
von der Hardt, S., Bakkers, J., Inbal, A., Carvalho, L., Solnica-Krezel, L., Heisenberg, C.P., and Hammerschmidt, M. (2007) The Bmp Gradient of the Zebrafish Gastrula Guides Migrating Lateral Cells by Regulating Cell-Cell Adhesion. Current biology : CB. 17(6):475-487
Panizzi, J.R., Jessen, J.R., Drummond, I.A., and Solnica-Krezel, L. (2007) New functions for a vertebrate Rho guanine nucleotide exchange factor in ciliated epithelia. Development (Cambridge, England). 134(5):921-931
Zeng, X.X., Wilm, T.P., Sepich, D.S., and Solnica-Krezel, L. (2007) Apelin and Its Receptor Control Heart Field Formation during Zebrafish Gastrulation. Developmental Cell. 12(3):391-402
Kim, H.S., Shin, J., Kim, S.H., Chun, H.S., Kim, J.D., Kim, Y.S., Kim, M.J., Rhee, M., Yeo, S.Y., and Huh, T.L. (2007) Eye field requires the function of Sfrp1 as a Wnt antagonist. Neuroscience letters. 414(1):26-29
Flynt, A.S., Li, N., Thatcher, E.J., Solnica-Krezel, L., and Patton, J.G. (2007) Zebrafish miR-214 modulates Hedgehog signaling to specify muscle cell fate. Nature Genetics. 39(2):259-263
Shin, J. (2007) Genetic analysis of neuronal and glial development in zebrafish. Ph.D. Thesis. :151p
Inbal, A., Topczewski, J., and Solnica-Krezel, L. (2006) Targeted gene expression in the zebrafish prechordal plate. Genesis (New York, N.Y. : 2000). 44(12):584-588
Kirby, B.B., Takada, N., Latimer, A.J., Shin, J., Carney, T.J., Kelsh, R.N., and Appel, B. (2006) In vivo time-lapse imaging shows dynamic oligodendrocyte progenitor behavior during zebrafish development. Nature Neuroscience. 9(12):1506-1511
Blaser, H., Reichman-Fried, M., Castanon, I., Dumstrei, K., Marlow, F.L., Kawakami, K., Solnica-Krezel, L., Heisenberg, C.P., and Raz, E. (2006) Migration of zebrafish primordial germ cells: a role for Myosin contraction and cytoplasmic flow. Developmental Cell. 11(5):613-627
Mendelsohn, B.A., Yin, C., Johnson, S.L., Wilm, T.P., Solnica-Krezel, L., and Gitlin, J.D. (2006) Atp7a determines a hierarchy of copper metabolism essential for notochord development. Cell Metabolism. 4(2):155-162
Solnica-Krezel, L. (2006) Gastrulation in zebrafish - all just about adhesion?. Current opinion in genetics & development. 16(4):433-441
Cha, Y.I., Solnica-Krezel, L., and Dubois, R.N. (2006) Fishing for prostanoids: Deciphering the developmental functions of cyclooxygenase-derived prostaglandins. Developmental Biology. 289(2):263-272
Cha, Y.I., Kim, S.H., Sepich, D., Buchanan, F.G., Solnica-Krezel, L., and Dubois, R.N. (2006) Cyclooxygenase-1-derived PGE2 promotes cell motility via the G-protein-coupled EP4 receptor during vertebrate gastrulation. Genes & Development. 20(1):77-86
Ng, A.N., de Jong-Curtain, T.A., Mawdsley, D.J., White, S.J., Shin, J., Appel, B., Dong, P.D., Stainier, D.Y., and Heath, J.K. (2005) Formation of the digestive system in zebrafish: III. Intestinal epithelium morphogenesis. Developmental Biology. 286(1):114-135
Sepich, D.S., Calmelet, C., Kiskowski, M., and Solnica-Krezel, L. (2005) Initiation of convergence and extension movements of lateral mesoderm during zebrafish gastrulation. Developmental dynamics : an official publication of the American Association of Anatomists. 234(2):279-292
Park, H.C., Boyce, J., Shin, J., and Appel, B. (2005) Oligodendrocyte specification in zebrafish requires notch-regulated cyclin-dependent kinase inhibitor function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(29):6836-6844
Lin, F., Sepich, D.S., Chen, S., Topczewski, J., Yin, C., Solnica-Krezel, L., and Hamm, H. (2005) Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements. The Journal of cell biology. 169(5):777-787
Cha, Y.I., Kim, S.H., Solnica-Krezel, L., and Dubois, R.N. (2005) Cyclooxygenase-1 signaling is required for vascular tube formation during development. Developmental Biology. 282(1):274-283
Latimer, A.J., Shin, J., and Appel, B. (2005) her9 promotes floor plate development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 232(4):1098-1104
Cooper, M.S., Szeto, D.P., Sommers-Herivel, G., Topczewski, J., Solnica-Krezel, L., Kang, H.C., Johnson, I., and Kimelman, D. (2005) Visualizing morphogenesis in transgenic zebrafish embryos using BODIPY TR methyl ester dye as a vital counterstain for GFP. Developmental dynamics : an official publication of the American Association of Anatomists. 232(2):359-368
Iovine, M.K., Higgins, E.P., Hindes, A., Coblitz, B., and Johnson, S.L. (2005) Mutations in connexin43 (GJA1) perturb bone growth in zebrafish fins. Developmental Biology. 278(1):208-219
Ninkovic, J., Tallafuss, A., Leucht, C., Topczewski, J., Tannhäuser, B., Solnica-Krezel, L., and Bally-Cuif, L. (2005) Inhibition of neurogenesis at the zebrafish midbrain-hindbrain boundary by the combined and dose-dependent activity of a new hairy/E(spl) gene pair. Development (Cambridge, England). 132(1):75-88
Sepich, D.S., and Solnica-Krezel, L. (2005) Analysis of cell movements in zebrafish embryos: morphometrics and measuring movement of labeled cell populations in vivo. Methods in molecular biology (Clifton, N.J.). 294:211-234
Wilm, T.P., and Solnica-Krezel, L. (2005) Essential roles of a zebrafish prdm1/blimp1 homolog in embryo patterning and organogenesis. Development (Cambridge, England). 132(2):393-404
Park, H.C., Shin, J., and Appel, B. (2004) Spatial and temporal regulation of ventral spinal cord precursor specification by Hedgehog signaling. Development (Cambridge, England). 131(23):5959-5969
Jessen, J.R., and Solnica-Krezel, L. (2004) Identification and developmental expression pattern of van gogh-like 1, a second zebrafish strabismus homologue. Gene expression patterns : GEP. 4(3):339-344
Marlow, F., Gonzalez, E.M., Yin, C., Rojo, C., and Solnica-Krezel, L. (2004) No tail co-operates with non-canonical Wnt signaling to regulate posterior body morphogenesis in zebrafish. Development (Cambridge, England). 131(1):203-216
Solnica-Krezel, L. and Eaton, S. (2003) Embryo morphogenesis: getting down to cells and molecules. Development (Cambridge, England). 130(18):4229-4233
Topczewska, J.M., Topczewski, J., Szostak, A., Solnica-Krezel, L., and Hogan, B.L.M. (2003) Developmentally regulated expression of two members of the Nrarp family in zebrafish. Gene expression patterns : GEP. 3(2):169-171
Wilm, T.P. and Solnica-Krezel, L. (2003) Radar breaks the fog: Insights into dorsoventral patterning in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 100(8):4363-4365
Lagutin, O.V., Zhu, C.C., Kobayashi, D., Topczewski, J., Shimamura, K., Puelles, L., Russell, H.R., McKinnon, P.J., Solnica-Krezel, L., and Oliver, G. (2003) Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes & Development. 17(3):368-379
Solnica-Krezel, L. (2003) Vertebrate development: taming the nodal waves. Current biology : CB. 13(1):R7-R9
Shin, J., Park, H.-C., Topczewska, J.M., Mawdsley, D.J., and Appel, B. (2003) Neural cell fate analysis in zebrafish using olig2 BAC transgenics. Methods in cell science : an official journal of the Society for In Vitro Biology. 25(1-2):7-14
Solnica-Krezel, L. (2002) Pattern Formation in Zebrafish. Springer-Verlag. :438 p
Kim, S.-H., Shin, J., Park, H.-C., Yeo, S.-Y., Hong, S.-K., Han, S., Rhee, M., Kim, C.-H., Chitnis, A.B., and Huh, T.-L. (2002) Specification of an anterior neuroectoderm patterning by Frizzled8a-mediated Wnt8b signalling during late gastrulation in zebrafish. Development (Cambridge, England). 129(19):4443-4455
Myers, D., Sepich, D. and Solnica-Krezel, L. (2002) Convergence and extension in vertebrate gastrulae: cell movements according to or in search of identity?. Trends in genetics : TIG. 18(9):447-455
Jessen, J.R., Topczewski, J., Bingham, S., Sepich, D.S., Marlow, F., Chandrasekhar, A., and Solnica-Krezel, L. (2002) Zebrafish trilobite identifies new roles for Strabismus in gastrulation and neuronal movements. Nature cell biology. 4(8):610-615
Solnica-Krezel, L., Marlow, F., Topczewski, J., Jessen, J., and Sepich, D. (2002) Regulation of cell polarity during zebrafish gastrulation. Developmental Biology. 247(2):479
Marlow, F., Topczewski, J., Sepich, D., and Solnica-Krezel, L. (2002) Zebrafish rho kinase 2 acts downstream of wnt11 to mediate cell polarity and effective convergence and extension movements. Current biology : CB. 12(11):876-884
Myers, D., Sepich, D., and Solnica-Krezel, L. (2002) Bmp activity gradient regulates convergent extension during zebrafish gastrulation. Developmental Biology. 243(1):81-98
Solnica-Krezel, L. and Cooper, M.S. (2002) Cellular and genetic mechanisms of convergence and extension. Results and problems in cell differentiation. 40:136-165
Topczewska, J.M., Topczewski, J., Shostak, A., Kume, T., Solnica-Krezel, L., and Hogan, B.L. (2001) The winged helix transcription factor Foxc1a is essential for somitogenesis in zebrafish. Genes & Development. 15(18):2483-2493
Erter, C.E., Wilm, T.P., Basler, N., Wright, C.V., and Solnica-Krezel, L. (2001) Wnt8 is required in lateral mesendodermal precursors for neural posteriorization in vivo. Development (Cambridge, England). 128(18):3571-3583
Topczewski, J., Sepich, D.S., Myers, D.C., Walker, C., Amores, A., Lele, Z., Hammerschmidt, M., Postlethwait, J., and Solnica-Krezel, L. (2001) The zebrafish glypican Knypek controls cell polarity during gastrulation movements of convergent extension. Developmental Cell. 1(2):251-264
Solnica-Krezel, L., Topczewski, J., Sepich, D., Myers, D., Marlow, F., and Jessen, J. (2001) Genetic control of convergent extension movements during zebrafish gastrulation. Developmental Biology. 235(1):175 (#17)
Solnica-Krezel, L. (2001) Genetic control of convergent extension movements during zebrafish gastrulation. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15(5):A745
Topczewska, J.M., Topczewski, J., Solnica-Krezel, L., and Hogan, B.L. (2001) Sequence and expression of zebrafish foxc1a and foxc1b, encoding conserved forkhead/winged helix transcription factors. Mechanisms of Development. 100(2):343-347
Solnica-Krezel, L. and Driever, W. (2001) The role of the homeodomain protein Bozozok in zebrafish axis formation. The International journal of developmental biology. 45(1):299-310
Gonzalez, E.M., Fekany-Lee, K., Carmany-Rampey, A., Erter, C., Topczewski, J., Wright, C.V.E., and Solnica-Krezel, L. (2000) Head and trunk in zebrafish arise via coinhibition of BMP signaling by bozozok and chordino. Genes & Development. 14(24):3087-3092
Henry, C.A., Crawford, B.D., Sepich, D., Cooper, M.S., and Hille, M. (2000) Subcellular localization of focal adhesion kinase during zebrafish organogenesis: Distinct roles for FAK in notochord and somite morphogenesis. Molecular biology of the cell. 11:297
Kawahara, A., Wilm, T., Solnica-Krezel, L., and Dawid, I.B. (2000) Antagonistic role of vega1 and bozozok/dharma homeobox genes in organizer formation. Proceedings of the National Academy of Sciences of the United States of America. 97(22):12121-12126
Kawahara, A., Wilm, T., Solnica-Krezel, L., and Dawid, I.B. (2000) Functional interaction of vega2 and goosecoid homeobox genes in zebrafish. Genesis (New York, N.Y. : 2000). 28(2):58-67
Henry, C.A., Hall, L.A., Hille, M.B., Solnica-Krezel, L., and Cooper, M.S. (2000) Somites in zebrafish doubly mutant for knypek and trilobite form without internal mesenchymal cells or compaction. Current biology : CB. 10(17):1063-1066
Pogoda, H.M., Solnica-Krezel, L., Driever, W., and Meyer, D. (2000) The zebrafish forkhead transcription factor FoxH1/Fast1 is a modulator of Nodal signaling required for organizer formation. Current biology : CB. 10(17):1041-1049
Sepich, D.S., Myers, D.C., Short, R., Topczewski, J., Marlow, F., and Solnica-Krezel, L. (2000) Role of the zebrafish trilobite locus in gastrulation movements of convergence and extension. Genesis (New York, N.Y. : 2000). 27(4):159-173
Fekany-Lee, K., Gonzalez, E., Miller-Bertoglio, V., and Solnica-Krezel, L. (2000) The homeobox gene bozozok promotes anterior neuroectoderm formation in zebrafish through negative regulation of BMP2/4 and Wnt pathways. Development (Cambridge, England). 127(11):2333-2345
Hashimoto, H., Itoh, M., Yamanaka, Y., Yamashita, S., Shimizu, T., Solnica-Krezel, L., Hibi, M., and Hirano, T. (2000) Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Developmental Biology. 217(1):138-152
Miller-Bertoglio, V., Carmany-Rampey, A., Fürthauer, M., Gonzalez, E.M., Thisse, C., Thisse, B., Halpern, M.E., and Solnica-Krezel, L. (1999) Maternal and zygotic activity of the zebrafish ogon locus antagonizes BMP signaling. Developmental Biology. 214(1):72-86
Fekany, K., Yamanaka, Y., Leung, T., Sirotkin, H.I., Topczewski, J., Gates, M.A., Hibi, M., Renucci, A., Stemple, D., Radbill, A., Schier, A.F., Driever, W., Hirano, T., Talbot, W.S., and Solnica-Krezel, L. (1999) The zebrafish bozozok locus encodes Dharma, a homeodomain protein essential for induction of gastrula organizer and dorsoanterior embryonic structures. Development (Cambridge, England). 126:1427-1438
Solnica-Krezel, L. (1999) Pattern formation in zebrafish--fruitful liaisons between embryology and genetics. Current topics in developmental biology. 41:1-35
Topczewski, J. and Solnica-Krezel, L. (1999) Cytoskeletal dynamics of the zebrafish embryo.. Methods in cell biology. 59:205-226
Erter, C.E., Solnica-Krezel, L., and Wright, C.V.E. (1998) Zebrafish nodal-related 2 encodes an early mesendodermal inducer signaling from the extraembryonic yolk syncytial layer. Developmental Biology. 204:361-372
Drummond, I.A., Majumdar, A., Hentschel, H., Elger, M., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Stemple, D.L., Zwartkruis, F., Rangini, Z., Driever, W., and Fishman, M.C. (1998) Early development of the zebrafish pronephros and analysis of mutations affecting pronephric function. Development (Cambridge, England). 125:4655-4667
Marlow, F., Zwartkruis, F., Malicki, J., Neuhauss, S.C.F., Abbas, L., Weaver, M., Driever, W., and Solnica-Krezel, L. (1998) Functional interactions of genes mediating convergent extension, knypek and trilobite, during the partitioning of the eye primordium in zebrafish. Developmental Biology. 203:382-399
Sampath, K., Rubinstein, A.L., Cheng, A.H.S., Liang, J.O., Fekany, K., Solnica-Krezel, L., Korzh, V., Halpern, M.E., and Wright, C.V.E. (1998) Induction of the zebrafish ventral brain and floorplate requires cyclops/nodal signalling. Nature. 395:185-189
Sepich, D.S., Wegner, J., O'Shea, S., and Westerfield, M. (1998) An altered intron inhibits synthesis of the acetylcholine receptor alpha-subunit in the paralyzed zebrafish mutant nic1. Genetics. 184:361-372
Driever, W., Solnica-Krezel, L., Abdelilah, S., Meyer, D., and Stemple, D. (1997) Genetic analysis of pattern formation in the zebrafish neural plate. Cold Spring Harbor symposia on quantitative biology. 62:523-534
Abdelilah, S., Mountcastle-Shah, E., Harvey, M., Solnica-Krezel, L., Schier, A.F., Stemple, D.L., Malicki, J., Neuhauss, S.C., Zwartkruis, F., Stainier, D.Y., Rangini, Z., and Driever, W. (1996) Mutations affecting neural survival in the zebrafish Danio rerio. Development (Cambridge, England). 123:217-227
Driever, W., Solnica-Krezel, L., Schier, A.F., Neuhauss, S.C., Malicki, J., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Rangini, Z., Belak, J., and Boggs, C. (1996) A genetic screen for mutations affecting embryogenesis in zebrafish. Development (Cambridge, England). 123:37-46
Malicki, J., Neuhauss, S.C., Schier, A.F., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Abdelilah, S., Zwartkruis, F., Rangini, Z., and Driever, W. (1996) Mutations affecting development of the zebrafish retina. Development (Cambridge, England). 123:263-273
Malicki, J., Schier, A.F., Solnica-Krezel, L., Stemple, D.L., Neuhauss, S.C., Stainier, D.Y., Abdelilah, S., Rangini, Z., Zwartkruis, F., and Driever, W. (1996) Mutations affecting development of the zebrafish ear. Development (Cambridge, England). 123:275-283
Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Abdelilah, S., Stainier, D.Y., and Driever, W. (1996) Mutations affecting craniofacial development in zebrafish. Development (Cambridge, England). 123:357-367
Pack, M., Solnica-Krezel, L., Malicki, J., Neuhauss, S.C., Schier, A-, F., Stemple, D.L., Driever, W., and Fishman, M.C. (1996) Mutations affecting development of zebrafish digestive organs. Development (Cambridge, England). 123:321-328
Schier, A.F., Neuhauss, S.C., Harvey, M., Malicki, J., Solnica-Krezel, L., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., Stemple, D.L., Rangini, Z., Yang, H., and Driever, W. (1996) Mutations affecting the development of the embryonic zebrafish brain. Development (Cambridge, England). 123:165-178
Solnica-Krezel, L., Stemple, D.L., Mountcastle-Shah, E., Rangini, Z., Neuhauss, S.C., Malicki, J., Schier, A.F., Stainier, D.Y., Zwartkruis, F., Abdelilah, S., and Driever, W. (1996) Mutations affecting cell fates and cellular rearrangements during gastrulation in zebrafish. Development (Cambridge, England). 123:67-80
Stainier, D.Y., Fouquet, B., Chen, J.N., Warren, K.S., Weinstein, B.M., Meiler, S.E., Mohideen, M.A., Neuhauss, S.C., Solnica-Krezel, L., Schier, A.F., Zwartkruis, F., Stemple, D.L., Malicki, J., Driever, W., and Fishman, M.C. (1996) Mutations affecting the formation and function of the cardiovascular system in the zebrafish embryo. Development (Cambridge, England). 123:285-292
Stemple, D.L., Solnica-Krezel, L., Zwartkruis, F., Neuhauss, S.C., Schier, A.F., Malicki, J., Stainier, D.Y., Abdelilah, S., Rangini, Z., Mountcastle-Shah, E., and Driever, W. (1996) Mutations affecting development of the notochord in zebrafish. Development (Cambridge, England). 123:117-128
Weinstein, B.M., Schier, A.F., Abdelilah, S., Malicki, J., Solnica-Krezel, L., Stemple, D.L., Stainier, D.Y., Zwartkruis, F., Driever, W., and Fishman, M.C. (1996) Hematopoietic mutations in the zebrafish. Development (Cambridge, England). 123:303-309
Abdelilah, S.,Driever, W., Gorn, A., Malicki,J., Neuhauss, S., Pack, M., Rangini, Z., Schier, A., Solnica-Krezel, L., Stanier, D., and Stemple, D. (1996) Anatomy of the 24, 48, 72 and 120 hours Zebrafish (Danio rerio) Embryo. ZFIN Direct Data Submission.
Solnica-Krezel, L., Stemple, D.L., and Driever, W. (1995) Transparent things: cell fates and cell movements during early embryogenesis of zebrafish. BioEssays : news and reviews in molecular, cellular and developmental biology. 17:931-939
Solnica-Krezel, L. and Driever, W. (1994) Microtubule arrays of the zebrafish yolk cell: organization and function during epiboly. Development (Cambridge, England). 120:3-2455
Abdelilah, S., Solnica-Krezel, L., Stainier, D.Y.R., and Driever, W. (1994) Implications for dorsoventral axis determination from the zebrafish mutation janus. Nature. 370:468-471
Driever, W., Stemple, D., Schier, A., and Solnica-Krezel, L. (1994) Zebrafish: genetic tools for studying vertebrate development. Trends in genetics : TIG. 10:152-159
Solnica-Krezel, L., Schier, A.F., and Driever, W. (1994) Efficient recovery of ENU-induced mutations from the zebrafish germline. Genetics. 136:1401-1420
Sepich, D.S. (1994) Characterizations of the zebrafish acetylcholine receptor mutant, nic1. Ph.D. Thesis.
Sepich, D.S., Ho, R.K., and Westerfield, M. (1994) Autonomous expression of the nic1 acetylcholine receptor mutation in zebrafish muscle cells. Developmental Biology. 161:84-90
Kimmel, C.B., Sepich, D.S., and Trevarrow, B. (1988) Development of segmentation in zebrafish. Development (Cambridge, England). 104:197-208
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