ZFIN ID: ZDB-LAB-090422-1
Ketting Lab
PI/Director: Ketting, René
Co-PI / Senior
Wittkopp, Nadine
Contact Person: Ketting, René
Email: R.Ketting@imb-mainz.de
Address: Institute of Molecular Biology (IMB) Ackermannweg 4, 55128 Mainz
Country: Germany
Line Designation: mz

Show all 11 genomic features

Primary research interests are germ cell development, small RNA mediated gene regulation and early development. Liquid-liquid phase separation (germ plasm) is another major focus.

Bronkhorst, Walter Post-Doc Caspani, Edoardo Graduate Student Consorte, Alessandro Graduate Student
Kornowska, Monika Fish Facility Staff Krehbiel, Saskia Fish Facility Staff El Sherif, Yasmin Technical Staff

Roovers, E.F., Kaaij, L.J.T., Redl, S., Bronkhorst, A.W., Wiebrands, K., de Jesus Domingues, A.M., Huang, H.Y., Han, C.T., Riemer, S., Dosch, R., Salvenmoser, W., Grün, D., Butter, F., van Oudenaarden, A., Ketting, R.F. (2018) Tdrd6a Regulates the Aggregation of Buc into Functional Subcellular Compartments that Drive Germ Cell Specification. Developmental Cell. 46:285-301.e9
Kaaij, L.J.T., van der Weide, R.H., Ketting, R.F., de Wit, E. (2018) Systemic Loss and Gain of Chromatin Architecture throughout Zebrafish Development. Cell Reports. 24:1-10.e4
Lebedeva, S., de Jesus Domingues, A.M., Butter, F., Ketting, R.F. (2017) Characterization of genetic loss-of-function of Fus in zebrafish. RNA Biology. 14(1):29-35
Kloosterman, W.P., Wienholds, E., Ketting, R.F., Plasterk, R.H. (2016) Expression of Concern: Substrate requirements for let-7 function in the developing zebrafish embryo. Nucleic acids research. 32(21):6284-6291
Kaaij, L.J., Mokry, M., Zhou, M., Musheev, M., Geeven, G., Melquiond, A.S., de Jesus Domingues, A.M., de Laat, W., Niehrs, C., Smith, A.D., Ketting, R.F. (2016) Enhancers reside in a unique epigenetic environment during early zebrafish development. Genome biology. 17:146
San, B., Chrispijn, N.D., Wittkopp, N., van Heeringen, S.J., Lagendijk, A.K., Aben, M., Bakkers, J., Ketting, R.F., Kamminga, L.M. (2016) Normal formation of a vertebrate body plan and loss of tissue maintenance in the absence of ezh2. Scientific Reports. 6:24658
Rosenkranz, D., Han, C.T., Roovers, E.F., Zischler, H., Ketting, R.F. (2015) Piwi proteins and piRNAs in mammalian oocytes and early embryos: From sample to sequence. Genomics Data. 5:309-13
Huang, H.Y., and Ketting, R.F. (2014) Isolation of zebrafish gonads for RNA isolation. Methods in molecular biology (Clifton, N.J.). :183-194
Basten, S.G., Davis, E.E., Gillis, A.J., van Rooijen, E., Stoop, H., Babala, N., Logister, I., Heath, Z.G., Jonges, T.N., Katsanis, N., Voest, E.E., van Eeden, F.J., Medema, R.H., Ketting, R.F., Schulte-Merker, S., Looijenga, L.H., and Giles, R.H. (2013) Mutations in LRRC50 Predispose Zebrafish and Humans to Seminomas. PLoS Genetics. 9(4):e1003384
Kaaij, L.J., Hoogstrate, S.W., Berezikov, E., and Ketting, R.F. (2013) piRNA dynamics in divergent zebrafish strains reveals long-lasting maternal influence on zygotic piRNA profiles. RNA (New York, N.Y.). 19(3):345-356
Huang, H.Y., Houwing, S., Kaaij, L.J., Meppelink, A., Redl, S., Gauci, S., Vos, H., Draper, B.W., Moens, C.B., Burgering, B.M., Ladurner, P., Krijgsveld, J., Berezikov, E., and Ketting, R.F. (2011) Tdrd1 acts as a molecular scaffold for Piwi proteins and piRNA targets in zebrafish. The EMBO journal. 30(16):3298-308
Kamminga, L.M., Luteijn, M.J., den Broeder, M.J., Redl, S., Kaaij, L.J., Roovers, E.F., Ladurner, P., Berezikov, E., and Ketting, R.F. (2010) Hen1 is required for oocyte development and piRNA stability in zebrafish. The EMBO journal. 29(21):3688-3700
den Broeder, M.J., van der Linde, H., Brouwer, J.R., Oostra, B.A., Willemsen, R., and Ketting, R.F. (2009) Generation and characterization of FMR1 knockout zebrafish. PLoS One. 4(11):e7910
Houwing, S., Berezikov, E., and Ketting, R.F. (2008) Zili is required for germ cell differentiation and meiosis in zebrafish. The EMBO journal. 27(20):2702-2711
Kloosterman, W.P., Lagendijk, A.K., Ketting, R.F., Moulton, J.D., and Plasterk, R.H. (2007) Targeted Inhibition of miRNA Maturation with Morpholinos Reveals a Role for miR-375 in Pancreatic Islet Development. PLoS Biology. 5(8):e203
Houwing, S., Kamminga, L.M., Berezikov, E., Cronembold, D., Girard, A., van den Elst, H., Filippov, D.V., Blaser, H., Raz, E., Moens, C.B., Plasterk, R.H., Hannon, G.J., Draper, B.W., and Ketting, R.F. (2007) A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell. 129(1):69-82