Lab
Tiso Lab
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Statement of Research Interest
Our research interests mainly concern signaling pathway analysis and disease modeling in zebrafish, with particular attention to the neural, pancreatic, thyroidal, cardiac and mitochondrial compartment.
These studies are carried out by mRNA and morpholino microinjection, microarray strategies, single or double whole mount in situ hybridisation in zebrafish embryos, xeno-transplantations, Crispr/Cas9 genome editing, analysis of mutants and production of pathway reporter transgenic lines.
These studies are carried out by mRNA and morpholino microinjection, microarray strategies, single or double whole mount in situ hybridisation in zebrafish embryos, xeno-transplantations, Crispr/Cas9 genome editing, analysis of mutants and production of pathway reporter transgenic lines.
Lab Members
| Zatti, Carlo MD/Veterinarian | Beffagna, Giorgia Post-Doc | Busolin, Giorgia Post-Doc |
| Facchinello, Nicola Post-Doc | Giuliodori, Alice Post-Doc | Porazzi, Patrizia Post-Doc |
| Risato, Giovanni Post-Doc | Branas Casas, Raquel Graduate Student | Milanetto, Martina Fish Facility Staff |
| Pivotti, Luigi Fish Facility Staff |
- Minoia, A., Piritore, F.C., Bolognin, S., Pessoa, J., Bernardes de Jesus, B., Tiso, N., Romanelli, M.G., Schwamborn, J.C., Dalle Carbonare, L., Valenti, M.T. (2025) Antioxidant, Osteogenic, and Neuroprotective Effects of Homotaurine in Aging and Parkinson's Disease Models. Antioxidants (Basel, Switzerland). 14:
- Astone, M., Tesoriero, C., Schiavone, M., Facchinello, N., Tiso, N., Argenton, F., Vettori, A. (2024) Wnt/β-Catenin Signaling Regulates Yap/Taz Activity during Embryonic Development in Zebrafish. International Journal of Molecular Sciences. 25(18):
- Brañas Casas, R., Zuppardo, A., Risato, G., Dinarello, A., Celeghin, R., Fontana, C., Grelloni, E., Gilea, A.I., Viscomi, C., Rasola, A., Dalla Valle, L., Lodi, T., Baruffini, E., Facchinello, N., Argenton, F., Tiso, N. (2024) Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment. Cell Death & Disease. 15:281281
- Barazzuol, L., Cieri, D., Facchinello, N., Calì, T., Washbourne, P., Argenton, F., Pizzo, P. (2023) Unraveling Presenilin 2 Functions in a Knockout Zebrafish Line to Shed Light into Alzheimer's Disease Pathogenesis. Cells. 12(3):
- Canato, E., Grigoletto, A., Zanotto, I., Tedeschini, T., Campara, B., Quaglio, G., Toffoli, G., Mandracchia, D., Dinarello, A., Tiso, N., Argenton, F., Sayaf, K., Guido, M., Gabbia, D., De Martin, S., Pasut, G. (2023) Anti-HER2 Super Stealth Immunoliposomes for Targeted-Chemotherapy. Advanced Healthcare Materials. 12(29):e2301650
- Celeghin, R., Risato, G., Beffagna, G., Cason, M., Bueno Marinas, M., Della Barbera, M., Facchinello, N., Giuliodori, A., Brañas Casas, R., Caichiolo, M., Vettori, A., Grisan, E., Rizzo, S., Dalla Valle, L., Argenton, F., Thiene, G., Tiso, N., Pilichou, K., Basso, C. (2023) A novel DSP zebrafish model reveals training- and drug-induced modulation of arrhythmogenic cardiomyopathy phenotypes. Cell death discovery. 9:441441
- Dalla Barba, F., Soardi, M., Mouhib, L., Risato, G., Akyürek, E.E., Lucon-Xiccato, T., Scano, M., Benetollo, A., Sacchetto, R., Richard, I., Argenton, F., Bertolucci, C., Carotti, M., Sandonà, D. (2023) Modeling Sarcoglycanopathy in Danio rerio. International Journal of Molecular Sciences. 24(16):
- Dinarello, A., Betto, R.M., Diamante, L., Tesoriere, A., Ghirardo, R., Cioccarelli, C., Meneghetti, G., Peron, M., Laquatra, C., Tiso, N., Martello, G., Argenton, F. (2023) STAT3 and HIF1α cooperatively mediate the transcriptional and physiological responses to hypoxia. Cell death discovery. 9:226226
- Fontana, C.M., Terrin, F., Facchinello, N., Meneghetti, G., Dinarello, A., Gambarotto, L., Zuccarotto, A., Caichiolo, M., Brocca, G., Verin, R., Nazio, F., Carnevali, O., Cecconi, F., Bonaldo, P., Dalla Valle, L. (2023) Zebrafish ambra1b knockout reveals a novel role for Ambra1 in primordial germ cells survival, sex differentiation and reproduction. Biological research. 56:1919
- Mignani, L., Facchinello, N., Varinelli, M., Massardi, E., Tiso, N., Ravelli, C., Mitola, S., Schu, P., Monti, E., Finazzi, D., Borsani, G., Zizioli, D. (2023) Deficiency of AP1 Complex Ap1g1 in Zebrafish Model Led to Perturbation of Neurodevelopment, Female and Male Fertility; New Insight to Understand Adaptinopathies. International Journal of Molecular Sciences. 24(8):
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