ZFIN Lab: Englert Lab

ZFIN ID: ZDB-LAB-070910-1

Englert Lab

PI/Director:	Englert, Christoph
Contact Person:	Perner, Birgit
Email:	perner@fli-leibniz.de
URL:	http://www.fli-leibniz.de/groups/englert_en.php
Address:	Molecular Genetics Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) Beutenbergstrasse 11 07745 Jena Germany
Country:	Germany
Phone:	+49 3641 656041
Fax:	+49 3641 656040
Line Designation:	li

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 21 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Bollig, Frank Post-Doc

Perner, Birgit Post-Doc

Reichardt, Claudia Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Marques, I.J., Ernst, A., Arora, P., Vianin, A., Hetke, T., Sanz-Morejón, A., Naumann, U., Odriozola, A., Langa, X., Andrés-Delgado, L., Zuber, B., Torroja, C., Osterwalder, M., Simões, F., Englert, C., Mercader, N. (2022) WT1 transcription factor impairs cardiomyocyte specification and drives a phenotypic switch from myocardium to epicardium. Development (Cambridge, England). 149(6):

Reuter, H., Perner, B., Wahl, F., Rohde, L., Koch, P., Groth, M., Buder, K., Englert, C. (2022) Aging Activates the Immune System and Alters the Regenerative Capacity in the Zebrafish Heart. Cells. 11(3):

Hopfenmüller, V.L., Perner, B., Reuter, H., Bates, T.J.D., Große, A., Englert, C. (2022) The Wilms Tumor Gene wt1a Contributes to Blood-Cerebrospinal Fluid Barrier Function in Zebrafish. Frontiers in cell and developmental biology. 9:809962

Lam, S., Hartmann, N., Benfeitas, R., Zhang, C., Arif, M., Turkez, H., Uhlén, M., Englert, C., Knight, R., Mardinoglu, A. (2021) Systems Analysis Reveals Ageing-Related Perturbations in Retinoids and Sex Hormones in Alzheimer's and Parkinson's Diseases. Biomedicines. 9(10):

Sanz-Morejón, A., García-Redondo, A.B., Reuter, H., Marques, I.J., Bates, T., Galardi-Castilla, M., Große, A., Manig, S., Langa, X., Ernst, A., Piragyte, I., Botos, M.A., González-Rosa, J.M., Ruiz-Ortega, M., Briones, A.M., Salaices, M., Englert, C., Mercader, N. (2019) Wilms Tumor 1b Expression Defines a Pro-regenerative Macrophage Subtype and Is Required for Organ Regeneration in the Zebrafish. Cell Reports. 28:1296-1306.e6

Große, A., Perner, B., Naumann, U., Englert, C. (2019) Zebrafish Wtx is a negative regulator of Wnt signaling but is dispensable for embryonic development and organ homeostasis. Developmental Dynamics : an official publication of the American Association of Anatomists. 248(9):866-881

Kindermann, B., Valkova, C., Krämer, A., Perner, B., Engelmann, C., Behrendt, L., Kritsch, D., Jungnickel, B., Kehlenbach, R.H., Oswald, F., Englert, C., Kaether, C. (2019) The nuclear pore proteins Nup88/214 and T-ALL-associated NUP214 fusion proteins regulate Notch signaling. The Journal of biological chemistry. 294(31):11741-11750

Lopez-Baez, J.C., Simpson, D.J., LLeras Forero, L., Zeng, Z., Brunsdon, H., Salzano, A., Brombin, A., Wyatt, C., Rybski, W., Huitema, L.F.A., Dale, R.M., Kawakami, K., Englert, C., Chandra, T., Schulte-Merker, S., Hastie, N.D., Patton, E.E. (2018) Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.. eLIFE. 7

Aramillo Irizar, P., Schäuble, S., Esser, D., Groth, M., Frahm, C., Priebe, S., Baumgart, M., Hartmann, N., Marthandan, S., Menzel, U., Müller, J., Schmidt, S., Ast, V., Caliebe, A., König, R., Krawczak, M., Ristow, M., Schuster, S., Cellerino, A., Diekmann, S., Englert, C., Hemmerich, P., Sühnel, J., Guthke, R., Witte, O.W., Platzer, M., Ruppin, E., Kaleta, C. (2018) Transcriptomic alterations during ageing reflect the shift from cancer to degenerative diseases in the elderly. Nature communications. 9:327

Perner, B., Schnerwitzki, D., Graf, M., Englert, C. (2016) Analysis of Zebrafish Kidney Development with Time-lapse Imaging Using a Dissecting Microscope Equipped for Optical Sectioning. Journal of visualized experiments : JoVE. (110):e53921

Baumgart, M., Priebe, S., Groth, M., Hartmann, N., Menzel, U., Pandolfini, L., Koch, P., Felder, M., Ristow, M., Englert, C., Guthke, R., Platzer, M., Cellerino, A. (2016) Longitudinal RNA-Seq Analysis of Vertebrate Aging Identifies Mitochondrial Complex I as a Small-Molecule-Sensitive Modifier of Lifespan. Cell systems. 2:122-132

Bates, T.J., Naumann, U., Englert, C. (2016) Fluorescence-Activated Cell Sorting (FACS) Protocol for Podocyte Isolation in Adult Zebrafish. Methods in molecular biology (Clifton, N.J.). 1467:133-6

Perner, B., Bates, T.J., Naumann, U., Englert, C. (2016) Function and Regulation of the Wilms' Tumor Suppressor 1 (WT1) Gene in Fish. Methods in molecular biology (Clifton, N.J.). 1467:119-28

Perner, B., Englert, C. (2016) Immunofluorescence Staining of Wt1 on Sections of Zebrafish Embryos and Larvae. Methods in molecular biology (Clifton, N.J.). 1467:129-32

Mansfeld, J., Urban, N., Priebe, S., Groth, M., Frahm, C., Hartmann, N., Gebauer, J., Ravichandran, M., Dommaschk, A., Schmeisser, S., Kuhlow, D., Monajembashi, S., Bremer-Streck, S., Hemmerich, P., Kiehntopf, M., Zamboni, N., Englert, C., Guthke, R., Kaleta, C., Platzer, M., Sühnel, J., Witte, O.W., Zarse, K., Ristow, M. (2015) Branched-chain amino acid catabolism is a conserved regulator of physiological ageing. Nature communications. 6:10043

Dong, L., Pietsch, S., Tan, Z., Perner, B., Sierig, R., Kruspe, D., Groth, M., Witzgall, R., Gröne, H., Platzer, M., Englert, C. (2015) Integration of Cistromic and Transcriptomic Analyses Identifies Nphs2, Mafb, and Magi2 as Wilms' Tumor 1 Target Genes in Podocyte Differentiation and Maintenance. Journal of the American Society of Nephrology : JASN. 26(9):2118-28

Schnerwitzki, D., Perner, B., Hoppe, B., Pietsch, S., Mehringer, R., Hänel, F., Englert, C. (2014) Alternative splicing of Wilms tumor suppressor 1 (Wt1) exon 4 results in protein isoforms with different functions. Developmental Biology. 393(1):24-32

Burghardt, T., Kastner, J., Suleiman, H., Rivera-Milla, E., Stepanova, N., Lottaz, C., Kubitza, M., Böger, C.A., Schmidt, S., Gorski, M., de Vries, U., Schmidt, H., Hertting, I., Kopp, J., Rascle, A., Moser, M., Heid, I.M., Warth, R., Spang, R., Wegener, J., Mierke, C.T., Englert, C., and Witzgall, R. (2013) LMX1B is Essential for the Maintenance of Differentiated Podocytes in Adult Kidneys. Journal of the American Society of Nephrology : JASN. 24(11):1830-48

Krämer, A., Mentrup, T., Kleizen, B., Rivera-Milla, E., Reichenbach, D., Enzensperger, C., Nohl, R., Täuscher, E., Görls, H., Ploubidou, A., Englert, C., Werz, O., Arndt, H.D., and Kaether, C. (2013) Small molecules intercept Notch signaling and the early secretory pathway. Nature Chemical Biology. 9(11):731-738

Kirsch, T., Kaufeld, J., Korstanje, R., Hentschel, D.M., Staggs, L., Bollig, F., Beese, M., Schroder, P., Boehme, L., Haller, H., and Schiffer, M. (2013) Knockdown of the Hypertension-Associated Gene NOSTRIN Alters Glomerular Barrier Function in Zebrafish (Danio rerio). Hypertension (Dallas, Tex. : 1979). 62(4):726-30

Petzold, A., Reichwald, K., Groth, M., Taudien, S., Hartmann, N., Priebe, S., Shagin, D., Englert, C., and Platzer, M. (2013) The transcript catalogue of the short-lived fish Nothobranchius furzeri provides insights into age-dependent changes of mRNA levels. BMC Genomics. 14:185

Schuler, S., Hauptmann, J., Perner, B., Kessels, M.M., Englert, C., and Qualmann, B. (2013) Ciliated sensory hair cell formation and function require the F-BAR protein syndapin I and the WH2 domain-based actin nucleator Cobl. Journal of Cell Science. 126(1):196-208

Stengel, R., Rivera-Milla, E., Sahoo, N., Ebert, C., Bollig, F., Heinemann, S.H., Schonherr, R., and Englert, C. (2012) Kcnh1 voltage-gated potassium channels are essential for early zebrafish development. The Journal of biological chemistry. 287(42):35565-35575

Müller, T., Rumpel, E., Hradetzky, S., Bollig, F., Wegner, H., Blumenthal, A., Greinacher, A., Endlich, K., and Endlich, N. (2011) Non-muscle myosin IIA is required for the development of the zebrafish glomerulus. Kidney International. 80(10):1055-63

Diep, C.Q., Ma, D., Deo, R.C., Holm, T.M., Naylor, R.W., Arora, N., Wingert, R.A., Bollig, F., Djordjevic, G., Lichman, B., Zhu, H., Ikenaga, T., Ono, F., Englert, C., Cowan, C.A., Hukriede, N.A., Handin, R.I., and Davidson, A.J. (2011) Identification of adult nephron progenitors capable of kidney regeneration in zebrafish. Nature. 470(7332):95-100

Landgraf, K., Bollig, F., Trowe, M.O., Besenbeck, B., Ebert, C., Kruspe, D., Kispert, A., Hänel, F., and Englert, C. (2010) Sipl1 and Rbck1 are novel Eya1-binding proteins with a role in craniofacial development. Molecular and cellular biology. 30(24):5764-5775

Zhou, W., Boucher, R.C., Bollig, F., Englert, C., and Hildebrandt, F. (2010) Characterization of Mesonephric Development and Regeneration Using Transgenic Zebrafish. American journal of physiology. Renal physiology. 299(5):F1040-F1047

Ashworth, S., Teng, B., Kaufeld, J., Miller, E., Tossidou, I., Englert, C., Bollig, F., Staggs, L., Roberts, I.S., Park, J.K., Haller, H., and Schiffer, M. (2010) Cofilin-1 inactivation leads to proteinuria--studies in zebrafish, mice and humans. PLoS One. 5(9):e12626

Miloslavina, A., Ebert, C., Tietze, D., Ohlenschläger, O., Englert, C., Görlach, M., and Imhof, D. (2010) An unusual peptide from Conus villepinii: synthesis, solutiuon structure, and cardioactivity. Peptides. 31(7):1292-1300

Kim, M.S., Yoon, S.K., Bollig, F., Kitagaki, J., Hur, W., Whye, N.J., Wu, Y.P., Rivera, M.N., Park, J.Y., Kim, H.S., Malik, K., Bell, D.W., Englert, C., Perantoni, A.O., and Lee, S.B. (2010) A novel Wilms Tumor 1 (WT1) target gene negatively regulates the WNT signaling pathway. The Journal of biological chemistry. 285(19):14585-14593

Bollig, F., Perner, B., Besenbeck, B., Köthe, S., Ebert, C., Taudien, S., and Englert, C. (2009) A highly conserved retinoic acid responsive element controls wt1a expression in the zebrafish pronephros. Development (Cambridge, England). 136(17):2883-2892

Skouloudaki, K., Puetz, M., Simons, M., Courbard, J.R., Boehlke, C., Hartleben, B., Engel, C., Moeller, M.J., Englert, C., Bollig, F., Schäfer, T., Ramachandran, H., Mlodzik, M., Huber, T.B., Kuehn, E.W., Kim, E., Kramer-Zucker, A., and Walz, G. (2009) Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development. Proceedings of the National Academy of Sciences of the United States of America. 106(21):8579-8584

Reichwald, K., Lauber, C., Nanda, I., Kirschner, J., Hartmann, N., Schories, S., Gausmann, U., Taudien, S., Schilhabel, M.B., Szafranski, K., Glockner, G., Schmid, M., Cellerino, A., Schartl, M., Englert, C., and Platzer, M. (2009) High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research. Genome biology. 10(2):R16

Perner, B., Englert, C., and Bollig, F. (2007) The Wilms tumor genes wt1a and wt1b control different steps during formation of the zebrafish pronephros. Developmental Biology. 309(1):87-96

Bollig, F., Mehringer, R., Perner, B., Hartung, C., Schafer, M., Schartl, M., Volff, J.N., Winkler, C., and Englert, C. (2006) Identification and comparative expression analysis of a second wt1 gene in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 235(2):554-561