ZFIN Lab: Higashijima Lab

ZFIN ID: ZDB-LAB-061108-1

Higashijima Lab

PI/Director:	Higashijima, Shin-ichi
Contact Person:	Higashijima, Shin-ichi
Email:	shigashi@nips.ac.jp
URL:
Address:	National Institutes of Natural Sciences Okazaki Institute for Integrative Bioscience Higashiyama 5-1 Myodaiji Okazaki Aichi 444-8787, Japan
Country:	Japan
Phone:
Fax:
Line Designation:	nns

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show first 50 of 70 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Pallucchi, I., Bertuzzi, M., Madrid, D., Fontanel, P., Higashijima, S.I., El Manira, A. (2023) Molecular blueprints for spinal circuit modules controlling locomotor speed in zebrafish. Nature Neuroscience. 27(1):78-89

Miyadai, M., Takada, H., Shiraishi, A., Kimura, T., Watakabe, I., Kobayashi, H., Nagao, Y., Naruse, K., Higashijima, S.I., Shimizu, T., Kelsh, R.N., Hibi, M., Hashimoto, H. (2023) A gene regulatory network combining Pax3/7, Sox10 and Mitf generates diverse pigment cell types in medaka and zebrafish. Development (Cambridge, England). 150(19):

Sugioka, T., Tanimoto, M., Higashijima, S.I. (2023) Biomechanics and neural circuits for vestibular-induced fine postural control in larval zebrafish. Nature communications. 14:12171217

Ma, M., Brunal, A.A., Clark, K.C., Studtmann, C., Stebbins, K., Higashijima, S.I., Pan, Y.A. (2023) Deficiency in the cell-adhesion molecule dscaml1 impairs hypothalamic CRH neuron development and perturbs normal neuroendocrine stress axis function. Frontiers in cell and developmental biology. 11:11136751113675

Tanimoto, M., Watakabe, I., Higashijima, S.I. (2022) Tiltable objective microscope visualizes selectivity for head motion direction and dynamics in zebrafish vestibular system. Nature communications. 13:76227622

Laureano, A.S., Flaherty, K., Hinman, A.M., Jadali, A., Nakamura, T., Higashijima, S.I., Sabaawy, H.E., Kwan, K.Y. (2022) shox2 is required for vestibular statoacoustic neuron development. Biology Open. 11(12):

Ratanayotha, A., Matsuda, M., Kimura, Y., Takenaga, F., Mizuno, T., Hossain, M.I., Higashijima, S.I., Kawai, T., Ogasawara, M., Okamura, Y. (2022) Voltage-sensing phosphatase (Vsp) regulates endocytosis-dependent nutrient absorption in chordate enterocytes. Communications biology. 5:948

Kawano, K., Kato, K., Sugioka, T., Kimura, Y., Tanimoto, M., Higashijima, S.I. (2022) Long descending commissural V0v neurons ensure coordinated swimming movements along the body axis in larval zebrafish. Scientific Reports. 12:4348

Böhm, U.L., Kimura, Y., Kawashima, T., Ahrens, M.B., Higashijima, S.I., Engert, F., Cohen, A.E. (2022) Voltage imaging identifies spinal circuits that modulate locomotor adaptation in zebrafish. Neuron. 110(7):1211-1222.e4

Liu, Z., Kimura, Y., Higashijima, S.I., Hildebrand, D.G.C., Morgan, J.L., Bagnall, M.W. (2020) Central Vestibular Tuning Arises from Patterned Convergence of Otolith Afferents. Neuron. 108(4):748-762.e4

Mizoguchi, T., Fukada, M., Iihama, M., Song, X., Fukagawa, S., Kuwabara, S., Omaru, S., Higashijima, S.I., Itoh, M. (2020) Transient activation of the Notch-her15.1 axis plays an important role in the maturation of V2b interneurons. Development (Cambridge, England). 147(16):

Uemura, Y., Kato, K., Kawakami, K., Kimura, Y., Oda, Y., Higashijima, S.I. (2020) Neuronal circuits that control rhythmic pectoral fin movements in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 40(35):6678-6690

Satou, C., Sugioka, T., Uemura, Y., Shimazaki, T., Zmarz, P., Kimura, Y., Higashijima, S.I. (2020) Functional Diversity of Glycinergic Commissural Inhibitory Neurons in Larval Zebrafish. Cell Reports. 30:3036-3050.e4

Frank, T., Mönig, N.R., Satou, C., Higashijima, S.I., Friedrich, R.W. (2019) Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area. Nature Neuroscience. 22(11):1844-1856

Callahan, R.A., Roberts, R., Sengupta, M., Kimura, Y., Higashijima, S.I., Bagnall, M.W. (2019) Spinal V2b neurons reveal a role for ipsilateral inhibition in speed control. eLIFE. 8:

Kimura, Y., Higashijima, S.I. (2019) Regulation of locomotor speed and selection of active sets of neurons by V1 neurons. Nature communications. 10:2268

Shimazaki, T., Tanimoto, M., Oda, Y., Higashijima, S.I. (2018) Behavioral role of the reciprocal inhibition between a pair of Mauthner cells during fast escapes in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39(7):1182-1194

Watakabe, I., Hashimoto, H., Kimura, Y., Yokoi, S., Naruse, K., Higashijima, S.I. (2018) Highly efficient generation of knock-in transgenic medaka by CRISPR/Cas9-mediated genome engineering. Zoological letters. 4:3

Taniguchi, A., Kimura, Y., Mori, I., Nonaka, S., Higashijima, S.I. (2017) Axially-confined in vivo single-cell labeling by primed conversion using blue and red lasers with conventional confocal microscopes. Development, growth & differentiation. 59(9):741-748

Ratanayotha, A., Kawai, T., Higashijima, S.I., Okamura, Y. (2017) Molecular and functional characterization of the voltage-gated proton channel in zebrafish neutrophils. Physiological Reports. 5(15)

Ota, S., Taimatsu, K., Yanagi, K., Namiki, T., Ohga, R., Higashijima, S.I., Kawahara, A. (2016) Functional visualization and disruption of targeted genes using CRISPR/Cas9-mediated eGFP reporter integration in zebrafish. Scientific Reports. 6:34991

Chou, M.Y., Amo, R., Kinoshita, M., Cherng, B.W., Shimazaki, H., Agetsuma, M., Shiraki, T., Aoki, T., Takahoko, M., Yamazaki, M., Higashijima, S., Okamoto, H. (2016) Social conflict resolution regulated by two dorsal habenular subregions in zebrafish. Science (New York, N.Y.). 352:87-90

Kawamura, A., Ovara, H., Ooka, Y., Kinoshita, H., Hoshikawa, M., Nakajo, K., Yokota, D., Fujino, Y., Higashijima, S.I., Takada, S., Yamasu, K. (2016) Posterior-anterior gradient of zebrafish hes6 expression in the presomitic mesoderm is established by the combinatorial functions of the downstream enhancer and 3'UTR. Developmental Biology. 409(2):543-54

Marquart, G.D., Tabor, K.M., Brown, M., Strykowski, J.L., Varshney, G.K., LaFave, M.C., Mueller, T., Burgess, S.M., Higashijima, S., Burgess, H.A. (2015) A 3D Searchable Database of Transgenic Zebrafish Gal4 and Cre Lines for Functional Neuroanatomy Studies. Frontiers in neural circuits. 9:78

Marquart, G.D., Tabor, K.M., Brown, M., Strykowski, J.L., Varshney, G.K., LaFave, M.C., Mueller, T., Burgess, S.H., Higashijima, S., and Burgess, H.A. (2015) Enhancer Trap Transgenics. ZFIN Direct Data Submission.

Amo, R., Fredes, F., Kinoshita, M., Aoki, R., Aizawa, H., Agetsuma, M., Aoki, T., Shiraki, T., Kakinuma, H., Matsuda, M., Yamazaki, M., Takahoko, M., Tsuboi, T., Higashijima, S.I., Miyasaka, N., Koide, T., Yabuki, Y., Yoshihara, Y., Fukai, T., Okamoto, H. (2014) The Habenulo-Raphe Serotonergic Circuit Encodes an Aversive Expectation Value Essential for Adaptive Active Avoidance of Danger. Neuron. 84:1034-1048

Kimura, Y., Hisano, Y., Kawahara, A., Higashijima, S. (2014) Efficient generation of knock-in transgenic zebrafish carrying reporter/driver genes by CRISPR/Cas9-mediated genome engineering. Scientific Reports. 4:6545

Okigawa, S., Mizoguchi, T., Okano, M., Tanaka, H., Isoda, M., Jiang, Y.J., Suster, M., Higashijima, S.I., Kawakami, K., Itoh, M. (2014) Different combinations of Notch ligands and receptors regulate V2 interneuron progenitor proliferation and V2a/V2b cell fate determination. Developmental Biology. 391(2):196-206

Hirabayashi, R., Hozumi, S., Higashijima, S.I., and Kikuchi, Y. (2013) Ddx46 Is Required for Multi-Lineage Differentiation of Hematopoietic Stem Cells in Zebrafish. Stem cells and development. 22(18):2532-42

Mizuno, H., Sassa, T., Higashijima, S.I., Okamoto, H., and Miyawaki, A. (2013) Transgenic zebrafish for ratiometric imaging of cytosolic and mitochondrial Ca2+ response in teleost embryo. Cell Calcium. 54(3):236-45

Satou, C., Kimura, Y., Hirata, H., Suster, M.L., Kawakami, K., and Higashijima, S. (2013) Transgenic tools to characterize neuronal properties of discrete populations of zebrafish neurons. Development (Cambridge, England). 140(18):3927-3931

Aoki, T., Kinoshita, M., Aoki, R., Agetsuma, M., Aizawa, H., Yamazaki, M., Takahoko, M., Amo, R., Arata, A., Higashijima, S.I., Tsuboi, T., and Okamoto, H. (2013) Imaging of Neural Ensemble for the Retrieval of a Learned Behavioral Program. Neuron. 78(5):881-894

Kimura, Y., Satou, C., Fujioka, S., Shoji, W., Umeda, K., Ishizuka, T., Yawo, H., and Higashijima, S. (2013) Hindbrain V2a Neurons in the Excitation of Spinal Locomotor Circuits during Zebrafish Swimming. Current biology : CB. 23(10):843-849

Shimozono, S., Iimura, T., Kitaguchi, T., Higashijima, S.I., and Miyawaki, A. (2013) Visualization of an endogenous retinoic acid gradient across embryonic development. Nature. 496(7445):363-6

Jusuf, P.R., Albadri, S., Paolini, A., Currie, P.D., Argenton, F., Higashijima, S., Harris, W.A., and Poggi, L. (2012) Biasing Amacrine Subtypes in the Atoh7 Lineage through Expression of Barhl2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(40):13929-13944

Eklöf-Ljunggren, E., Haupt, S., Ausborn, J., Dehnisch, I., Uhlén, P., Higashijima, S.I., and El Manira, A. (2012) Origin of excitation underlying locomotion in the spinal circuit of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 109(14):5511-5516

Asakawa, K., Higashijima, S.I., and Kawakami, K. (2012) An mnr2b/hlxb9lb enhancer trap line that labels spinal and abducens motor neurons in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 241(2):327-332

Satou, C., Kimura, Y., and Higashijima, S. (2012) Generation of multiple classes of v0 neurons in zebrafish spinal cord: progenitor heterogeneity and temporal control of neuronal diversity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(5):1771-1783

Behra, M., Gallardo, V.E., Bradsher, J., Torrado, A., Elkahloun, A., Idol, J., Sheehy, J., Zonies, S., Xu, L., Shaw, K.M., Satou, C., Higashijima, S.I., Weinstein, B.M., and Burgess, S.M. (2012) Transcriptional signature of accessory cells in the lateral line, using the Tnk1bp1:EGFP transgenic zebrafish line. BMC Developmental Biology. 12(1):6

Tsutsui, H., Higashijima, S., Miyawaki, A., and Okamura, Y. (2011) Visualizing voltage dynamics in Zebrafish heart. Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology. 138(6):234-238

Muto, A., Ohkura, M., Kotani, T., Higashijima, S.I., Nakai, J., and Kawakami, K. (2011) Genetic visualization with an improved GCaMP calcium indicator reveals spatiotemporal activation of the spinal motor neurons in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(13):5425-5430

Wibowo, I., Pinto-Teixeira, F., Satou, C., Higashijima, S., and Lopez-Schier, H. (2011) Compartmentalized Notch signaling sustains epithelial mirror symmetry. Development (Cambridge, England). 138(6):1143-1152

Kinkhabwala, A., Riley, M., Koyama, M., Monen, J., Satou, C., Kimura, Y., Higashijima, S.I., and Fetcho, J. (2011) A structural and functional ground plan for neurons in the hindbrain of zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 108(3):1164-1169

Koyama, M., Kinkhabwala, A., Satou, C., Higashijima, S.I., and Fetcho, J. (2011) Mapping a sensory-motor network onto a structural and functional ground plan in the hindbrain. Proceedings of the National Academy of Sciences of the United States of America. 108(3):1170-1175

Agetsuma, M., Aizawa, H., Aoki, T., Nakayama, R., Takahoko, M., Goto, M., Sassa, T., Amo, R., Shiraki, T., Kawakami, K., Hosoya, T., Higashijima, S.I., and Okamoto, H. (2010) The habenula is crucial for experience-dependent modification of fear responses in zebrafish. Nature Neuroscience. 13(11):1354-1356

Kani, S., Bae, Y.K., Shimizu, T., Tanabe, K., Satou, C., Parsons, M.J., Scott, E., Higashijima, S.I., and Hibi, M. (2010) Proneural gene-linked neurogenesis in zebrafish cerebellum. Developmental Biology. 343(1-2):1-17

Tsutsui, H., Higashijima, S.I., Miyawaki, A., and Okamura, Y. (2010) Visualizing Voltage Dynamics in Zebrafish Heart. The Journal of physiology. 588(Pt 12):2017-2021

Wada, H., Ghysen, A., Satou, C., Higashijima, S.I., Kawakami, K., Hamaguchi, S., and Sakaizumi, M. (2010) Dermal morphogenesis controls lateral line patterning during postembryonic development of teleost fish. Developmental Biology. 340(2):583-594

Sugiyama, M., Sakaue-Sawano, A., Iimura, T., Fukami, K., Kitaguchi, T., Kawakami, K., Okamoto, H., Higashijima, S.I., and Miyawaki, A. (2009) Illuminating cell-cycle progression in the developing zebrafish embryo. Proceedings of the National Academy of Sciences of the United States of America. 106(49):20812-20817

Bae, Y.K., Kani, S., Shimizu, T., Tanabe, K., Nojima, H., Kimura, Y., Higashijima, S.I., and Hibi, M. (2009) Anatomy of zebrafish cerebellum and screen for mutations affecting its development. Developmental Biology. 330(2):406-426

Satou, C., Kimura, Y., Kohashi, T., Horikawa, K., Takeda, H., Oda, Y., and Higashijima, S. (2009) Functional role of a specialized class of spinal commissural inhibitory neurons during fast escapes in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(21):6780-6793

Miyasaka, N., Morimoto, K., Tsubokawa, T., Higashijima, S., Okamoto, H., and Yoshihara, Y. (2009) From the olfactory bulb to higher brain centers: genetic visualization of secondary olfactory pathways in zebrafish. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29(15):4756-4767

Vitorino, M., Jusuf, P.R., Maurus, D., Yukiko, Y., Higashijima, S.I., and Harris, W.A. (2009) Vsx2 in the zebrafish retina: restricted lineages through derepression. Neural Development. 4:14

Kimura, Y., Satou, C., and Higashijima, S.I. (2008) V2a and V2b neurons are generated by the final divisions of pair-producing progenitors in the zebrafish spinal cord. Development (Cambridge, England). 135(18):3001-3005

Higashijima, S.I. (2008) Transgenic zebrafish expressing fluorescent proteins in central nervous system neurons. Development, growth & differentiation. 50(6):407-413

Hossain, M.I., Iwasaki, H., Okochi, Y., Chahine, M., Higashijima, S., Nagayama, K., and Okamura, Y. (2008) Enzyme domain affects the movement of the voltage sensor in ascidian and zebrafish VSPs. The Journal of biological chemistry. 283(26):18248-18259

Fetcho, J.R., Higashijima, S.I., and McLean, D.L. (2008) Zebrafish and motor control over the last decade. Brain Research Reviews. 57(1):86-93

McLean, D.L., Fan, J., Higashijima, S., Hale, M.E., and Fetcho, J.R. (2007) A topographic map of recruitment in spinal cord. Nature. 446(7131):71-75

Kimura, Y., Okamura, Y., and Higashijima, S. (2006) alx, a zebrafish homolog of Chx10, marks ipsilateral descending excitatory interneurons that participate in the regulation of spinal locomotor circuits. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26(21):5684-5697

Li, J., Mack, J.A., Souren, M., Yaksi, E., Higashijima, S., Mione, M., Fetcho, J.R., and Friedrich, R.W. (2005) Early development of functional spatial maps in the zebrafish olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(24):5784-95

Uemura, O., Okada, Y., Ando, H., Guedj, M., Higashijima, S., Shimazaki, T., Chino, N., Okano, H., and Okamoto, H. (2005) Comparative functional genomics revealed conservation and diversification of three enhancers of the isl1 gene for motor and sensory neuron-specific expression. Developmental Biology. 278(2):587-606

Higashijima, S.I., Mandel, G., and Fetcho, J.R. (2004) Distribution of prospective glutamatergic, glycinergic, and GABAergic neurons in embryonic and larval zebrafish. The Journal of comparative neurology. 480(1):1-18

Higashijima, S.I., Schaefer, M., and Fetcho, J.R. (2004) Neurotransmitter properties of spinal interneurons in embryonic and larval zebrafish. The Journal of comparative neurology. 480(1):19-37

Higashijima, S., Masino, M.A., Mandel, G., and Fetcho, J.R. (2004) Engrailed-1 expression marks a primitive class of inhibitory spinal interneuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(25):5827-5839

Li, W.C., Higashijima, S., Parry, D.M., Roberts, A., and Soffe, S.R. (2004) Primitive roles for inhibitory interneurons in developing frog spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(25):5840-5848

Higashijima, S.I., Masino, M.A., Mandel, G., and Fetcho, J.R. (2003) Imaging neuronal activity during zebrafish behavior with a genetically encoded calcium indicator. Journal of neurophysiology. 90(6):3986-3997

Gleason, M.R., Higashijima, S.I., Dallman, J., Liu, K., Mandel, G., and Fetcho, J.R. (2003) Translocation of CaM kinase II to synaptic sites in vivo. Nature Neuroscience. 6(3):217-218

Zeller, J., Schneider, V., Malayaman, S., Higashijima, S., Okamoto, H., Gui, J., Lin, S., and Granato, M. (2002) Migration of zebrafish spinal motor nerves into the periphery requires multiple myotome-derived cues. Developmental Biology. 252(2):241-256

Ono, F., Shcherbatko, A., Higashijima, S.-I., Mandel, G., and Brehm, P. (2002) The zebrafish motility mutant twitch once reveals new roles for rapsyn in synaptic function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22(15):6491-6498

Bingham, S., Higashijima, S.-I., Okamoto, H., and Chandrasekhar, A. (2002) The zebrafish trilobite gene is essential for tangential migration of branchiomotor neurons. Developmental Biology. 242(2):149-160

Ono, F., Higashijima, S., Shcherbatko, A., Fetcho, J.R., and Brehm, P. (2001) Paralytic zebrafish lacking acetylcholine receptors fail to localize rapsyn clusters to the synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21(15):5439-5448

Segawa, H., Miyashita, T., Hirate, Y., Higashijima, S., Chino, N., Uyemura, K., Kikuchi, Y., and Okamoto, H. (2001) Functional repression of islet-2 by disruption of complex with Ldb impairs peripheral axonal outgrowth in embryonic zebrafish. Neuron. 30(2):423-436

Wada, H., Okamoto, H., and Higashijima, S. (2000) [Study of mechanisms for the axonal pathfinding of the trigeminal motor neurons by using transgenic zebrafish].. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 45(Suppl. 17):2803-2809

Higashijima, S., Hotta, Y., and Okamoto, H. (2000) Visualization of cranial motor neurons in live transgenic zebrafish expressing green fluorescent protein under the control of the islet-1 promoter/enhancer. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20(1):206-218

Higashijima, S., Nose, A., Eguchi, G., Hotta, Y., and Okamoto, H. (1997) Mindin/F-spondin family: novel ECM proteins expressed in the zebrafish embryonic axis. Developmental Biology. 192:211-227

Higashijima, S., Okamoto, H., Ueno, N., Hotta, Y., and Eguchi, G. (1997) High-frequency generation of transgenic zebrafish which reliably express GFP in whole muscles or the whole body by using promoters of zebrafish origin. Developmental Biology. 192:289-299