ZFIN ID: ZDB-LAB-040810-2
Goldsmith Lab
PI/Director: Goldsmith, Matt
Contact Person: Goldsmith, Matt
Email: goldsmith_m@kids.wustl.edu
URL: http://peds.wustl.edu/research/labs/Goldsmith_Matthew_I/
Address: Department of Pediatrics Washington University School of Medicine MPRB, 7th Floor, Entry 6 4938 Parkview Place St. Louis, MO 63110 USA
Country: United States
Phone: (314) 286-2869
Fax: (314) 286-2893
Line Designation: gw

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All or our patients are growing. Indeed, it's the sine qua non of pediatric medicine that distinguishes us from all other physicians. The research efforts of our laboratory center on understanding the biology of growth and regeneration. Growth control and the development of proper size and form is a fundamental problem for growing children, moreover multiple pediatric diseases result in undergrowth, overgrowth or dysregulated growth (i.e. structural birth defects). In addition, while many animals are capable of extensive regeneration, the ability of diseased or damaged tissues and organs to regenerate in humans is quite limited.

We are using the zebrafish, Danio rerio, as a model system for studying the biology of growth and regeneration. Current studies are focused on: 1) Using fin overgrowth mutants already identified in forward genetic screens (e.g. rapunzel) to help dissect the genetics of growth control pathways; 2) Using forward genetic and pharmacologic screens to identify novel pathways/molecules important in organ regeneration, and; 3) Understanding how the nutritional environment is integrated into an overall hierarchy of growth regulatory signals.

Charney, Rachel Post-Doc Taylor, Jennifer Post-Doc Koerber, Amy Fish Facility Staff

Buchan, J.G., Gray, R.S., Gansner, J.M., Alvarado, D.M., Burgert, L., Gitlin, J.D., Gurnett, C.A., Goldsmith, M.I. (2014) Kinesin family member 6 (kif6) is necessary for spine development in zebrafish. Developmental dynamics : an official publication of the American Association of Anatomists. 243(12):1646-57
Ha, K., Buchan, J.G., Alvarado, D.M., McCall, K., Vydyanath, A., Luther, P.K., Goldsmith, M.I., Dobbs, M.B., and Gurnett, C.A. (2013) MYBPC1 mutations impair skeletal muscle function in zebrafish models of arthrogryposis. Human molecular genetics. 22(24):4967-77
Oppedal, D., and Goldsmith, M.I. (2010) A Chemical Screen to Identify Novel Inhibitors of Fin Regeneration in Zebrafish. Zebrafish. 7(1):53-60
Green, J., Taylor, J.J., Hindes, A., Johnson, S.L., and Goldsmith, M.I. (2009) A gain of function mutation causing skeletal overgrowth in the rapunzel mutant. Developmental Biology. 334(1):224-234
Koerber, A.S., and Kalishman, J. (2009) Preparing for a Semiannual IACUC Inspection of a Satellite Zebrafish (Danio rerio) Facility. Journal of the American Association for Laboratory Animal Science : JAALAS. 48(1):65-75
Mumm, J.S., Williams, P.R., Godinho, L., Koerber, A., Pittman, A.J., Roeser, T., Chien, C.B., Baier, H., and Wong, R.O. (2006) In vivo imaging reveals dendritic targeting of laminated afferents by zebrafish retinal ganglion cells. Neuron. 52(4):609-621
Goldsmith, M.I., Iovine, M.K., O'reilly-Pol, T., and Johnson, S.L. (2006) A developmental transition in growth control during zebrafish caudal fin development. Developmental Biology. 296(2):450-457
Goldsmith, M.I., Fisher, S., Waterman, R., and Johnson, S.L. (2003) Saltatory control of isometric growth in the zebrafish caudal fin is disrupted in long fin and rapunzel mutants. Developmental Biology. 259(2):303-317