ZFIN ID: ZDB-LAB-040116-2
Tropepe Lab
PI/Director: Tropepe, Vincent
Contact Person: Tropepe, Vincent
Email: v.tropepe@utoronto.ca
URL: http://web.me.com/v.tropepe/Tropepe_Lab_at_University_of_Toronto/Welcome.html
Address: Department of Cell & Systems Biology University of Toronto 25 Harbord Street, RW 618 Toronto, Ontario, M5S 3G5 Canada
Country: Canada
Phone: (416) 946-0338
Fax: (416) 978-8532
Line Designation: uot

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Our lab investigates the molecular and cellular processes that govern neurogenesis during development and in the adult brain.

Forgione, Nicole Graduate Student Wong, Loksum Graduate Student

Miles, A., Blair, C., Emili, A., Tropepe, V. (2021) Usher syndrome Type 1-associated gene, pcdh15b, is required for photoreceptor structural integrity in zebrafish. Disease models & mechanisms. 14(12):
Wolf, E.J., Miles, A., Lee, E.S., Nabeel-Shah, S., Greenblatt, J.F., Palazzo, A.F., Tropepe, V., Emili, A. (2020) MKRN2 Physically Interacts with GLE1 to Regulate mRNA Export and Zebrafish Retinal Development. Cell Reports. 31:107693
Lindsey, B.W., Hall, Z.J., Heuzé, A., Joly, J.S., Tropepe, V., Kaslin, J. (2018) The role of neuro-epithelial-like and radial-glial stem and progenitor cells in development, plasticity, and repair. Prog. Neurobiol.. 170:99-114
Hall, Z.J., Tropepe, V. (2018) Movement maintains forebrain neurogenesis via peripheral neural feedback in larval zebrafish. eLIFE. 7
Hall, Z.J., Tropepe, V. (2018) Visual experience facilitates BDNF-dependent adaptive recruitment of new neurons in the postembryonic optic tectum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38(8):2000-2014
Morrow, J.M., Lazic, S., Fox, M.D., Kuo, C., Schott, R.K., Gutierrez, E.A., Santini, F., Tropepe, V., Chang, B.S. (2017) A second visual rhodopsin gene, rh1-2, is expressed in zebrafish photoreceptors and found in other ray-finned fishes. The Journal of experimental biology. 220(Pt 2):294-303
Olsen, J.B., Wong, L., Deimling, S., Miles, A., Guo, H., Li, Y., Zhang, Z., Greenblatt, J.F., Emili, A., Tropepe, V. (2016) G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis. Stem Cell Reports. 7(3):454-70
Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63
Miles, A., Tropepe, V. (2016) Coordinating progenitor cell cycle exit and differentiation in the developing vertebrate retina. Neurogenesis (Austin, Tex.). 3:e1161697
Wong, L., Power, N., Miles, A., Tropepe, V. (2015) Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression. Developmental Biology. 402(2):216-28
Ben-Omran, T., Fahiminiya, S., Sorfazlian, N., Almuriekhi, M., Nawaz, Z., Nadaf, J., Abu Khadija, K., Zaineddin, S., Kamel, H., Majewski, J., Tropepe, V. (2015) Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome. Journal of Medical Genetics. 52(6):381-90
Hall, Z.J., De Serrano, A.R., Rodd, F.H., Tropepe, V. (2014) Casting a wider fish net on animal models in neuropsychiatric research. Progress in neuro-psychopharmacology & biological psychiatry. 55C:7-15
Lindsey, B.W., Di Donato, S., Kaslin, J., Tropepe, V. (2014) Sensory-specific modulation of adult neurogenesis in sensory structures is associated with the type of stem cell present in the neurogenic niche of the zebrafish brain. The European journal of neuroscience. 40(11):3591-607
Lindsey, B.W., Tropepe, V. (2014) Changes in the social environment induce neurogenic plasticity predominantly in niches residing in sensory structures of the zebrafish brain independently of cortisol levels. Developmental Neurobiology. 74(11):1053-77
Lindsey, B.W., Darabie, A., and Tropepe, V. (2012) The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain. The Journal of comparative neurology. 520(10):2275-2316
Kalueff, A.V., Stewart, A.M., Kyzar, E.J., Cachat, J., Gebhardt, M., Landsman, S., Robinson, K., Maximino, C., Herculano, A.M., Jesuthasan, S., Wisenden, B., Bally-Cuif, L., Lange, M., Vernier, P., Norton, W., Tierney, K., Tropepe, V., and Neuhauss, S. (2012) Time to recognize zebrafish ‘affective’ behavior. Behaviour. 149:1019-1036
de Souza, B.R., Romano-Silva, M.A., and Tropepe, V. (2011) Dopamine d2 receptor activity modulates akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31(14):5512-5525
de Souza, B.R., and Tropepe, V. (2011) The role of dopaminergic signalling during larval zebrafish brain development: a tool for investigating the developmental basis of neuropsychiatric disorders. Reviews in the Neurosciences. 22(1):107-119
Wong, L., Weadick, C.J., Kuo, C., Chang, B.S., and Tropepe, V. (2010) Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development. BMC Developmental Biology. 10:100
Chang, L., Khoo, B., Wong, L., and Tropepe, V. (2006) Genomic sequence and spatiotemporal expression comparison of zebrafish mbx1 and its paralog, mbx2. Development genes and evolution. 216(10):647-654
Tropepe, V. and Sive, H.L. (2003) Can zebrafish be used as a model to study the neurodevelopmental causes of autism?. Genes, brain, and behavior. 2(5):268-281