ZFIN ID: ZDB-LAB-020725-1
Friedrich Lab
PI/Director: Friedrich, Rainer
Contact Person: Friedrich, Rainer
Email: Rainer.Friedrich@fmi.ch
URL: http://www.fmi.ch/friedrich.r/
Address: Friedrich Miescher Institute for Biomedical Research Maulbeerstrasse 66 Basel CH-4058 Switzerland
Country: Switzerland
Phone: 41-61-6978614
Fax: 41-61-6973976
Line Designation: fmi

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In adult zebrafish, we combine electrophysiology, imaging (mainly 2-photon calcium imaging), optogenetics, behavior and computational modeling to study the representation and processing of odor information in the olfactory system. Furthermore, we study the functional development of neuronal circuits in the olfactory bulb, reconstruct neuronal circuits by 3D-EM, and create transgenic lines as tools.

Anneser, Lukas Post-Doc

Gemmer, A., Mirkes, K., Anneser, L., Eilers, T., Kibat, C., Mathuru, A., Ryu, S., Schuman, E. (2022) Oxytocin receptors influence the development and maintenance of social behavior in zebrafish (Danio rerio). Scientific Reports. 12:4322
Anneser, L., Gemmer, A., Eilers, T., Alcantara, I.C., Loos, A.Y., Ryu, S., Schuman, E.M. (2022) The neuropeptide Pth2 modulates social behavior and anxiety in zebrafish. iScience. 25:103868
Rupprecht, P., Carta, S., Hoffmann, A., Echizen, M., Blot, A., Kwan, A.C., Dan, Y., Hofer, S.B., Kitamura, K., Helmchen, F., Friedrich, R.W. (2021) A database and deep learning toolbox for noise-optimized, generalized spike inference from calcium imaging. Nature Neuroscience. 24(9):1324-1337
Anneser, L., Alcantara, I.C., Gemmer, A., Mirkes, K., Ryu, S., Schuman, E.M. (2020) The neuropeptide Pth2 dynamically senses others via mechanosensation. Nature. 588(7839):653-657
Huang, K.H., Rupprecht, P., Frank, T., Kawakami, K., Bouwmeester, T., Friedrich, R.W. (2020) A virtual reality system to analyze neural activity and behavior in adult zebrafish. Nature Methods. 17(3):343-351
Wanner, A.A., Friedrich, R.W. (2020) Whitening of odor representations by the wiring diagram of the olfactory bulb. Nature Neuroscience. 23(3):433-442
Frank, T., Mönig, N.R., Satou, C., Higashijima, S.I., Friedrich, R.W. (2019) Associative conditioning remaps odor representations and modifies inhibition in a higher olfactory brain area. Nature Neuroscience. 22(11):1844-1856
Rupprecht, P., Friedrich, R.W. (2018) Precise Synaptic Balance in the Zebrafish Homolog of Olfactory Cortex. Neuron. 100(3):669-683.e5
Genoud, C., Titze, B., Graff-Meyer, A., Friedrich, R.W. (2018) Fast Homogeneous En Bloc Staining of Large Tissue Samples for Volume Electron Microscopy.. Frontiers in Neuroanatomy. 12:76
Namekawa, I., Moenig, N.R., Friedrich, R.W. (2018) Rapid olfactory discrimination learning in adult zebrafish. Experimental brain research. 236(11):2959-2969
Jacobson, G.A., Rupprecht, P., Friedrich, R.W. (2017) Experience-Dependent Plasticity of Odor Representations in the Telencephalon of Zebrafish. Current biology : CB. 28(1):1-14.e3
Wanner, A.A., Genoud, C., Friedrich, R.W. (2016) 3-dimensional electron microscopic imaging of the zebrafish olfactory bulb and dense reconstruction of neurons. Scientific data. 3:160100
Wanner, A.A., Genoud, C., Masudi, T., Siksou, L., Friedrich, R.W. (2016) Dense EM-based reconstruction of the interglomerular projectome in the zebrafish olfactory bulb. Nature Neuroscience. 19:816-825
Rupprecht, P., Prendergast, A., Wyart, C., Friedrich, R.W. (2016) Remote z-scanning with a macroscopic voice coil motor for fast 3D multiphoton laser scanning microscopy. Biomedical Optics Express. 7:1656-71
Zou, M., Friedrich, R.W., Bianco, I.H. (2016) Targeted Electroporation in Embryonic, Larval, and Adult Zebrafish. Methods in molecular biology (Clifton, N.J.). 1451:259-69
Friedrich, R.W., Wiechert, M.T. (2014) Neuronal circuits and computations: pattern decorrelation in the olfactory bulb. FEBS letters. 588(15):2504-2513
Zou, M., De Koninck, P., Neve, R.L., Friedrich, R.W. (2014) Fast gene transfer into the adult zebrafish brain by herpes simplex virus 1 (HSV-1) and electroporation: methods and optogenetic applications. Frontiers in neural circuits. 8:41
Friedrich, R.W. (2014) Calcium imaging in the intact olfactory system of zebrafish and mouse. Cold Spring Harbor protocols. 2014:310-6
Zhu, P., Frank, T., Friedrich, R.W. (2013) Equalization of odor representations by a network of electrically coupled inhibitory interneurons. Nature Neuroscience. 16:1678-86
Hinz, C., Namekawa, R., Behrmann-Godel, J., Oppelt, C., Jaeschke, A., Müller, A., Friedrich, R.W., and Gerlach, G. (2013) Olfactory imprinting is triggered by MHC peptide ligands. Scientific Reports. 3:2800
Friedrich, R.W. (2013) Neuronal Computations in the Olfactory System of Zebrafish. Annual review of neuroscience. 36:383-402
Miyasaka, N., Wanner, A.A., Li, J., Mack-Bucher, J., Genoud, C., Yoshihara, Y., and Friedrich, R.W. (2013) Functional development of the olfactory system in zebrafish. Mechanisms of Development. 130(6-8):336-46
Friedrich, R.W., Genoud, C., and Wanner, A.A. (2013) Analyzing the structure and function of neuronal circuits in zebrafish. Frontiers in neural circuits. 7:71
Fajardo, O., Zhu, P., and Friedrich, R.W. (2013) Control of a specific motor program by a small brain area in zebrafish. Frontiers in neural circuits. 7:67
Schärer, Y.P., Shum, J., Moressis, A., and Friedrich, R.W. (2012) Dopaminergic modulation of synaptic transmission and neuronal activity patterns in the zebrafish homolog of olfactory cortex. Frontiers in neural circuits. 6:76
Honisch, C., Friedrich, R., Hörner, F., and Denz, C. (2012) Extended Kramers-Moyal analysis applied to optical trapping. Physical review. E, Statistical, nonlinear, and soft matter physics. 86(2 Pt 2):026702
Zhu, P., Fajardo, O., Shum, J., Zhang Schärer, Y.P., and Friedrich, R.W. (2012) High-resolution optical control of spatiotemporal neuronal activity patterns in zebrafish using a digital micromirror device. Nature Protocols. 7(7):1410-1425
Bundschuh, S.T., Zhu, P., Schärer, Y.P., and Friedrich, R.W. (2012) Dopaminergic modulation of mitral cells and odor responses in the zebrafish olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32(20):6830-6840
Mathuru, A.S., Kibat, C., Cheong, W.F., Shui, G., Wenk, M.R., Friedrich, R.W., and Jesuthasan, S. (2012) Chondroitin fragments are odorants that trigger fear behavior in fish. Current biology : CB. 22(6):538-544
Blumhagen, F., Zhu, P., Shum, J., Schärer, Y.P., Yaksi, E., Deisseroth, K., and Friedrich, R.W. (2011) Neuronal filtering of multiplexed odour representations. Nature. 479(7374):493-8
Wiechert, M.T., Judkewitz, B., Riecke, H., and Friedrich, R.W. (2010) Mechanisms of pattern decorrelation by recurrent neuronal circuits. Nature Neuroscience. 13(8):1003-1010
Niessing, J., and Friedrich, R.W. (2010) Olfactory pattern classification by discrete neuronal network states. Nature. 465(7294):47-52
Friedrich, R.W., Jacobson, G.A., and Zhu, P. (2010) Circuit neuroscience in zebrafish. Current biology : CB. 20(8):R371-R381
Zhu, P., Narita, Y., Bundschuh, S.T., Fajardo, O., Schärer, Y.P., Chattopadhyaya, B., Bouldoires, E.A., Stepien, A.E., Deisseroth, K., Arber, S., Sprengel, R., Rijli, F.M., and Friedrich, R.W. (2009) Optogenetic Dissection of Neuronal Circuits in Zebrafish using Viral Gene Transfer and the Tet System. Frontiers in neural circuits. 3:21
Friedrich, R.W., Yaksi, E., Judkewitz, B., and Wiechert, M.T. (2009) Processing of odor representations by neuronal circuits in the olfactory bulb. Annals of the New York Academy of Sciences. 1170:293-297
Yaksi, E., von Saint Paul, F., Niessing, J., Bundschuh, S.T., and Friedrich, R.W. (2009) Transformation of odor representations in target areas of the olfactory bulb. Nature Neuroscience. 12(4):474-482
Tabor, R., Yaksi, E., and Friedrich, R.W. (2008) Multiple functions of GABA(A) and GABA(A) receptors during pattern processing in the zebrafish olfactory bulb. The European journal of neuroscience. 28(1):117-127
Tabor, R., and Friedrich, R.W. (2008) Pharmacological analysis of ionotropic glutamate receptor function in neuronal circuits of the zebrafish olfactory bulb. PLoS One. 3(1):e1416
Yaksi, E., Judkewitz, B., and Friedrich, R.W. (2007) Topological Reorganization of Odor Representations in the Olfactory Bulb. PLoS Biology. 5(7):e178
Mack-Bucher, J.A., Li, J., and Friedrich, R.W. (2007) Early functional development of interneurons in the zebrafish olfactory bulb. The European journal of neuroscience. 25(2):460-470
Yaksi, E., and Friedrich, R.W. (2006) Reconstruction of firing rate changes across neuronal populations by temporally deconvolved Ca2+ imaging. Nature Methods. 3(5):377-383
Feng, B., Bulchand, S., Yaksi, E., Friedrich, R.W., and Jesuthasan, S.J. (2005) The recombination activation gene 1 (Rag1) is expressed in a subset of zebrafish olfactory neurons but is not essential for axon targeting or amino acid detection. BMC Neuroscience. 6:46
Li, J., Mack, J.A., Souren, M., Yaksi, E., Higashijima, S., Mione, M., Fetcho, J.R., and Friedrich, R.W. (2005) Early development of functional spatial maps in the zebrafish olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25(24):5784-95
Friedrich, R.W., Habermann, C.J., and Laurent, G. (2004) Multiplexing using synchrony in the zebrafish olfactory bulb. Nature Neuroscience. 7(8):862-871
Tabor, R., Yaksi, E., Weislogel, J.M., and Friedrich, R.W. (2004) Processing of odor mixtures in the zebrafish olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(29):6611-6620
Friedrich, R.W., and Laurent, G. (2004) Dynamics of olfactory bulb input and output activity during odor stimulation in zebrafish. Journal of neurophysiology. 91(6):2658-2669
Sidi, S., Busch-Nentwich, E., Friedrich, R., Schoenberger, U., and Nicolson, T. (2004) gemini encodes a zebrafish L-type calcium channel that localizes at sensory hair cell ribbon synapses. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24(17):4213-4223
Sidi, S., Friedrich, R.W., and Nicolson, T. (2003) NompC TRP channel required for vertebrate sensory hair cell mechanotransduction. Science (New York, N.Y.). 301(5629):96-99
Friedrich, R.W. and Stopfer, M. (2001) Recent dynamics in olfactory population coding. Current opinion in neurobiology. 11:468-474
Friedrich, R.W. and Laurent, G. (2001) Dynamic optimization of odor representations by slow temporal patterning of mitral cell activity. Science (New York, N.Y.). 291(5505):889-894
Friedrich, R.W. and Laurent, G. (2000) Ensemble representation of odors in the zebrafish olfactory bulb. The European journal of neuroscience. 12:496
Friedrich, R.W. and Korsching, S.I. (1998) Chemotopic, combinatorial, and noncombinatorial odorant representations in the olfactory bulb revealed using a voltage-sensitive axon tracer. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18:9977-9988
Nicolson, T., Rüsch, A., Friedrich, R.W., Granato, M., Ruppersberg, J.P., and Nüsslein-Volhard, C. (1998) Genetic analysis of vertebrate sensory hair cell mechanosensation: the zebrafish circler mutants. Neuron. 20:271-283
Friedrich, R.W. and Korsching, S.I. (1997) Combinatorial and chemotopic odorant coding in the zebrafish olfactory bulb visualized by optical imaging. Neuron. 18(5):737-752
Korsching, S.I., Argo, S., Campenhausen, H., Friedrich, R.W., Rummrich, A., and Weth, F. (1997) Olfaction in zebrafish: what does a tiny teleost tell us?. Seminars in cell & developmental biology. 8:181-187