ZFIN Lab: Childs Lab

ZFIN ID: ZDB-LAB-010814-1

Childs Lab

PI/Director:	Childs, Sarah J.
Contact Person:	Childs, Sarah J.
Email:	schilds@ucalgary.ca
URL:	http://homepages.ucalgary.ca/~schilds/Childs.htm
Address:	Smooth Muscle Research Group Department of Biochemistry and Molecular Biology University of Calgary 3330 Hospital Drive NW Calgary, Alberta, T2N 4N1 Canada
Country:	Canada
Phone:	(403) 220-8277
Fax:	(403) 270-2211
Line Designation:	ca

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 23 genomic features

STATEMENT OF RESEARCH INTERESTS

LAB MEMBERS

Zeng, Lei Post-Doc

Lamont, Ryan Graduate Student

Liu, Jing Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

McGarry, S.D., Adjekukor, C., Ahuja, S., Greysson-Wong, J., Vien, I., Rinker, K.D., Childs, S.J. (2023) Vessel Metrics: A software tool for automated analysis of vascular structure in confocal imaging. Microvascular Research. 151:104610104610

Greysson-Wong, J., Rode, R., Ryu, J.R., Chan, J.L., Davari, P., Rinker, K.D., Childs, S.J. (2023) rasa1-related arteriovenous malformation is driven by aberrant venous signalling. Development (Cambridge, England). 150(18):

Ryu, J.R., Ahuja, S., Arnold, C.R., Potts, K.G., Mishra, A., Yang, Q., Sargurupremraj, M., Mahoney, D.J., Seshadri, S., Debette, S., Childs, S.J. (2022) Stroke-associated intergenic variants modulate a human FOXF2 transcriptional enhancer. Proceedings of the National Academy of Sciences of the United States of America. 119:e2121333119

Zink, M., Seewald, A., Rohrbach, M., Brodehl, A., Liedtke, D., Williams, T., Childs, S.J., Gerull, B. (2022) Altered Expression of TMEM43 Causes Abnormal Cardiac Structure and Function in Zebrafish. International Journal of Molecular Sciences. 23(17)

Blackwell, D.L., Fraser, S.D., Caluseriu, O., Vivori, C., Tyndall, A.V., Lamont, R.E., Parboosingh, J.S., Innes, A.M., Bernier, F.P., Childs, S.J. (2022) Hnrnpul1 controls transcription, splicing, and modulates skeletal and limb development in vivo. G3 (Bethesda). 12(5):

Watterston, C., Halabi, R., McFarlane, S., Childs, S.J. (2021) Endothelial Semaphorin 3fb regulates Vegf pathway-mediated angiogenic sprouting. PLoS Genetics. 17:e1009769

Bahrami, N., Childs, S.J. (2020) Development of vascular regulation in the zebrafish embryo. Development (Cambridge, England). 147(10):

Whitesell, T.R., Chrystal, P.W., Ryu, J.R., Munsie, N., Grosse, A., French, C.R., Workentine, M.L., Li, R., Zhu, L.J., Waskiewicz, A., Lehmann, O.J., Lawson, N.D., Childs, S.J. (2019) foxc1 is required for embryonic head vascular smooth muscle differentiation in zebrafish. Developmental Biology. 453(1):34-47

Guo, J.C., Fang, S.S., Wu, Y., Zhang, J.H., Chen, Y., Liu, J., Wu, B., Wu, J.R., Li, E.M., Xu, L.Y., Sun, L., Zhao, Y. (2019) CNIT: a fast and accurate web tool for identifying protein-coding and long non-coding transcripts based on intrinsic sequence composition. Nucleic acids research. 47(W1):W516-W522

Watterston, C., Zeng, L., Onabadejo, A., Childs, S.J. (2019) MicroRNA26 attenuates vascular smooth muscle maturation via endothelial BMP signalling. PLoS Genetics. 15:e1008163

Brodehl, A., Rezazadeh, S., Williams, T., Munsie, N.M., Liedtke, D., Oh, T., Ferrier, R., Shen, Y., Jones, S.J.M., Stiegler, A.L., Boggon, T.J., Duff, H.J., Friedman, J.M., Gibson, W.T., FORGE Canada Consortium, Childs, S.J., Gerull, B. (2019) Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy. Translational research : the journal of laboratory and clinical medicine. 208:15-29

Krall, M., Htun, S., Schnur, R.E., Brooks, A.S., Baker, L., de Alba Campomanes, A., Lamont, R.E., Gripp, K.W., Care 4 Rare Canada Consortium, Schneidman-Duhovny, D., Innes, A.M., Mancini, G.M.S., Slavotinek, A.M. (2019) Biallelic sequence variants in INTS1 in patients with developmental delays, cataracts, and craniofacial anomalies. European journal of human genetics : EJHG. 27(4):582-593

Gomez-Garcia, M.J., Doiron, A.L., Steele, R.R.M., Labouta, H.I., Vafadar, B., Shepherd, R.D., Gates, I.D., Cramb, D.T., Childs, S.J., Rinker, K.D. (2018) Nanoparticle localization in blood vessels: dependence on fluid shear stress, flow disturbances, and flow-induced changes in endothelial physiology. Nanoscale. 10(32):15249-15261

Bahrami, N., Childs, S.J. (2018) Pericyte Biology in Zebrafish. Advances in experimental medicine and biology. 1109:33-51

Yang, Y., Ji, D., Huang, X., Zhang, J., Liu, J. (2017) Effects of metals on enantioselective toxicity and biotransformation of cis-bifenthrin in zebrafish. Environmental toxicology and chemistry. 36(8):2139-2146

Zhang, J., Liu, J., Wang, L.M., Li, Z.Y., Yuan, Z. (2017) Retroreflective-type Janus microspheres as a novel contrast agent for enhanced optical coherence tomography. Journal of biophotonics. 10(6-7):878-886

Jiang, X.Y., Sarsons, C.D., Gomez-Garcia, M.J., Cramb, D.T., Rinker, K.D., Childs, S.J. (2017) Quantum Dot Interactions and Flow Effects in Angiogenic Zebrafish (Danio rerio) Vessels and Human Endothelial Cells. Nanomedicine : nanotechnology, biology, and medicine. 13(3):999-1010

Cheng, J., Lv, S., Nie, S., Liu, J., Tong, S., Kang, N., Xiao, Y., Dong, Q., Huang, C., Yang, D. (2016) Chronic perfluorooctane sulfonate (PFOS) exposure induces hepatic steatosis in zebrafish. Aquatic toxicology (Amsterdam, Netherlands). 176:45-52

Hanwell, D., Hutchinson, S.A., Collymore, C., Bruce, A.E., Louis, R., Ghalami, A., Allison, W.T., Ekker, M., Eames, B.F., Childs, S., Kurrasch, D.M., Gerlai, R., Thiele, T., Scott, I., Ciruna, B., Dowling, J.J., McFarlane, S., Huang, P., Wen, X.Y., Akimenko, M.A., Waskiewicz, A.J., Drapeau, P., Babiuk, L.A., Dragon, D., Smida, A., Buret, A.G., O'Grady, E., Wilson, J., Sowden-Plunkett, L., Tropepe, V. (2016) Restrictions on the Importation of Zebrafish into Canada Associated with Spring Viremia of Carp Virus. Zebrafish. 13 Suppl 1:S153-63

Lamont, R.E., Wu, C.Y., Ryu, J.R., Vu, W., Davari, P., Sobering, R.E., Kennedy, R.M., Munsie, N.M., Childs, S.J. (2016) The LIM-homeodomain transcription factor Islet2a promotes angioblast migration. Developmental Biology. 414:181-92

Yang, Y., Ye, X., He, B., Liu, J. (2016) Cadmium potentiates toxicity of cypermethrin in zebrafish. Environmental toxicology and chemistry. 35(2):435-45

Goi, M., Childs, S.J. (2016) Patterning Mechanisms of the Sub-Intestinal Venous Plexus in Zebrafish. Developmental Biology. 409(1):114-28

Wheway, G., Schmidts, M., Mans, D.A., Szymanska, K., Nguyen, T.M., Racher, H., Phelps, I.G., Toedt, G., Kennedy, J., Wunderlich, K.A., Sorusch, N., Abdelhamed, Z.A., Natarajan, S., Herridge, W., van Reeuwijk, J., Horn, N., Boldt, K., Parry, D.A., Letteboer, S.J., Roosing, S., Adams, M., Bell, S.M., Bond, J., Higgins, J., Morrison, E.E., Tomlinson, D.C., Slaats, G.G., van Dam, T.J., Huang, L., Kessler, K., Giessl, A., Logan, C.V., Boyle, E.A., Shendure, J., Anazi, S., Aldahmesh, M., Al Hazzaa, S., Hegele, R.A., Ober, C., Frosk, P., Mhanni, A.A., Chodirker, B.N., Chudley, A.E., Lamont, R., Bernier, F.P., Beaulieu, C.L., Gordon, P., Pon, R.T., Donahue, C., Barkovich, A.J., Wolf, L., Toomes, C., Thiel, C.T., Boycott, K.M., McKibbin, M., Inglehearn, C.F., Stewart, F., Omran, H., Huynen, M.A., Sergouniotis, P.I., Alkuraya, F.S., Parboosingh, J.S., Innes, A.M., Willoughby, C.E., Giles, R.H., Webster, A.R., Ueffing, M., Blacque, O., Gleeson, J.G., Wolfrum, U., Beales, P.L., Gibson, T., Doherty, D., Mitchison, H.M., Roepman, R., Johnson, C.A. (2015) An siRNA-based functional genomics screen for the identification of regulators of ciliogenesis and ciliopathy genes. Nature cell biology. 17:1074-87

Arnold, C.R., Lamont, R.E., Walker, J.T., Spice, P.J., Chan, C.K., Ho, C.Y., Childs, S.J. (2015) Comparative analysis of genes regulated by Dzip1/iguana and Hedgehog in zebrafish. Developmental Dynamics : an official publication of the American Association of Anatomists. 244(2):211-23

Tamplin, O.J., Durand, E.M., Carr, L.A., Childs, S.J., Hagedorn, E.J., Li, P., Yzaguirre, A.D., Speck, N.A., Zon, L.I. (2015) Hematopoietic Stem Cell Arrival Triggers Dynamic Remodeling of the Perivascular Niche. Cell. 160:241-252

French, C.R., Seshadri, S., Destefano, A.L., Fornage, M., Arnold, C.R., Gage, P.J., Skarie, J.M., Dobyns, W.B., Millen, K.J., Liu, T., Dietz, W., Kume, T., Hofker, M., Emery, D.J., Childs, S.J., Waskiewicz, A.J., Lehmann, O.J. (2014) Mutation of FOXC1 and PITX2 induces cerebral small-vessel disease. J. Clin. Invest.. 124(11):4877-81

Ebert, A.M., Childs, S.J., Hehr, C.L., Cechmanek, P.B., McFarlane, S. (2014) Sema6a and Plxna2 mediate spatially regulated repulsion within the developing eye to promote eye vesicle cohesion. Development (Cambridge, England). 141:2473-82

Whitesell, T.R., Kennedy, R.M., Carter, A.D., Rollins, E.L., Georgijevic, S., Santoro, M.M., Childs, S.J. (2014) An alpha-smooth muscle actin (acta2/alphasma) zebrafish transgenic line marking vascular mural cells and visceral smooth muscle cells. PLoS One. 9:e90590

Yang, Y., Ma, H., Zhou, J., Liu, J., and Liu, W. (2014) Joint toxicity of permethrin and cypermethrin at sublethal concentrations to the embryo-larval zebrafish. Chemosphere. 96:146-154

Christoph, S., Deryckere, D., Schlegel, J., Frazer, J.K., Batchelor, L.A., Trakhimets, A.Y., Sather, S., Hunter, D.M., Cummings, C., Liu, J., Yang, C., Kireev, D., Simpson, C., Norris-Drouin, J., Hull-Ryde, E.A., Janzen, W.P., Johnson, G.L., Wang, X., Frye, S.V., Earp, H.S., and Graham, D.K. (2013) UNC569, a novel small molecule Mer inhibitor with efficacy against acute lymphoblastic leukemia in vitro and in vivo. Molecular cancer therapeutics. 12(11):2367-77

Zeng, L., and Childs, S.J. (2012) The smooth muscle microRNA miR-145 regulates gut epithelial development via a paracrine mechanism. Developmental Biology. 367(2):178-186

Ebert, A.M., Lamont, R.E., Childs, S.J., and McFarlane, S. (2012) Neuronal expression of class 6 semaphorins in zebrafish. Gene expression patterns : GEP. 12(3-4):117-122

Liu, J., Zeng, L., Kennedy, R.M., Gruenig, N.M., and Childs, S.J. (2012) betaPix plays a dual role in cerebral vascular stability and angiogenesis, and interacts with integrin alphavbeta8. Developmental Biology. 363(1):95-105

Christie, T.L., Carter, A., Rollins, E.L., and Childs, S.J. (2010) Syk and Zap-70 function redundantly to promote angioblast migration. Developmental Biology. 340(1):22-29

Lamont, R.E., Vu, W., Carter, A.D., Serluca, F.C., MacRae, C.A., and Childs, S.J. (2010) Hedgehog signaling via angiopoietin1 is required for developmental vascular stability. Mechanisms of Development. 127(3-4):159-168

Zuccolo, J., Bau, J., Childs, S.J., Goss, G.G., Sensen, C.W., and Deans, J.P. (2010) Phylogenetic Analysis of the MS4A and TMEM176 Gene Families. PLoS One. 5(2):e9369

Zeng, L., Carter, A.D., and Childs, S.J. (2009) miR-145 directs intestinal maturation in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 106(42):17793-17798

Lamont, R.E., Lamont, E.J., and Childs, S.J. (2009) Antagonistic interactions among Plexins regulate the timing of intersegmental vessel formation. Developmental Biology. 331(2):199-209

Wang, N., Sun, Y.H., Liu, J., Wu, G., Su, J.G., Wang, Y.P., and Zhu, Z.Y. (2007) Knock down of gfp and no tail expression in zebrafish embryo by in vivo-transcribed short hairpin RNA with T7 plasmid system. Journal of Biomedical Science. 14(6):767-776

Callander, D.C., Lamont, R.E., Childs, S.J., and McFarlane, S. (2007) Expression of multiple class three semaphorins in the retina and along the path of zebrafish retinal axons. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(10):2918-2924

Liu, J., Fraser, S.D., Faloon, P.W., Rollins, E.L., Vom Berg, J., Starovic-Subota, O., Laliberte, A.L., Chen, J.N., Serluca, F.C., and Childs, S.J. (2007) A βPix–Pak2a signaling pathway regulates cerebral vascular stability in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 104(35):13990-13995

Georgijevic, S., Subramanian, Y., Rollins, E.L., Starovic-Subota, O., Tang, A.C., Childs, S.J. (2007) Spatiotemporal expression of smooth muscle markers in developing zebrafish gut. Developmental Dynamics : an official publication of the American Association of Anatomists. 236(6):1623-1632

Wang, N., Sun, Y.H., Liu, J., Wang, Y.P., and Zhu, Z.Y. (2007) Molecular characterization of common carp (Cyprinus carpio) Sonic Hedgehog and discovery of its maternal expression. Development genes and evolution. 217(4):299-305

Liu, J., Sun, Y.H., Wang, N., Wang, Y.P., and Zhu, Z.Y. (2006) Cloning, characterization and promoter analysis of common carp hairy/Enhancer-of-split-related gene, her6. Journal of genetics. 85(3):171-178

Liu, J., Sun, Y.H., Wang, N., Wang, Y.P., and Zhu, Z.Y. (2006) Upstream Regulatory Region of Zebrafish lunatic fringe: Isolation and Promoter Analysis. Marine biotechnology (New York, N.Y.). 8(4):357-365

Christie, T.L., Starovic-Subota, O., and Childs, S. (2006) Zebrafish collapsin response mediator protein (CRMP)-2 is expressed in developing neurons. Gene expression patterns : GEP. 6(2):193-200

Torres-Vazquez, J., Gitler, A.D., Fraser, S.D., Berk, J.D., Pham, V.N., Fishman, M.C., Childs, S., Epstein, J.A., and Weinstein, B.M. (2004) Semaphorin-plexin signaling guides patterning of the developing vasculature. Developmental Cell. 7(1):117-123

Garrity, D.M., Childs, S., and Fishman, M.C. (2002) The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome. Development (Cambridge, England). 129(19):4635-4645

Roman, B.L., Pham, V., Lawson, N.D., Kulik, M., Childs, S., Lekven, A.C., Garrity, D.M., Moon, R.T., Fishman, M.C., Lechleider, R.J., and Weinstein, B.M. (2002) Disruption of acvrl1 increases endothelial cell number in zebrafish cranial vessels. Development (Cambridge, England). 129(12):3009-3019

Childs, S., Chen, J.-N., Garrity, D.M., and Fishman, M.C. (2002) Patterning of angiogenesis in the zebrafish embryo. Development (Cambridge, England). 129(4):973-982

Zhong, T.P., Childs, S., Leu, J.P., and Fishman, M.C. (2001) Gridlock signalling pathway fashions the first embryonic artery. Nature. 414(6860):216-220

Chen, J.-N., van Bebber, F., Goldstein, A.M., Serluca, F.C., Jackson, D., Childs, S., Serbedzija, G., Warren, K.S., Mably, J.D., Lindahl, P., Mayer, A., Haffter, P., and Fishman, M.C. (2001) Genetic steps to organ laterality in zebrafish. Comparative and functional genomics. 2(2):60-68

Childs, S., Weinstein, B.M., Mohideen, M.A.P.K., Donohue, S., Bonkovsky, H., and Fishman, M.C. (2000) Zebrafish dracula encodes ferrochelatase and its mutation provides a model for erythropoietic protoporphyria. Current biology : CB. 10(16):1001-1004