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Figure 2.
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- Gan et al., 2026 - COMMD9-regulated endothelial cell abnormality-induced hypercoagulability is associated with Budd-Chiari syndrome
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Figure 2.
Cluster2 genes enriched for rare variants in the BCS group are intolerant to loss-of-function mutations based on PPI network analysis. (A) The PPI network was constructed using STRING and 2037 significant genes detected in the SKAT analysis. (B) Distribution of pLI scores for all genes, known VaMs-associated genes, and 10 gene clusters identified by ClusterOne. (C) PPI among proteins encoded by genes in Cluster2. (D) Ratio of NSV to SV for rare variants (defined as MAF < 0.01) among all genes, known VaMs-associated genes, and genes in Cluster2. ***P < 0.001; **P < 0.01.
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