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Fig S12

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Publication: Docampo-Seara et al., 2026 - The microglia-derived protein sema4ab attenuates regenerative neurogenesis after spinal cord injury in zebrafish
All Figures: Figures for Docampo-Seara et al., 2026

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Fig S12 scRNA-seq shows that genes analyzed in this study are also expressed in a spinal injury site in adult zebrafish.
(A) UMAP of the main cell types in the lesion site of adult zebrafish from Cigliola et al. 2023 Nat Commun 14:4857 is shown. (B) Feature plots show the expression of reference genes for relevant cell types (microglia: p2ry12; ERGs: her4.1; and fibroblasts-like cells: pdgfrb), as well as the expression of genes of interest for this study, sema4ab, plxnb1a, plxnb1b and tgfb3. Circles label expression in cell types that is conserved between larvae and adults. (C) HCR-FISH in cross sections of unlesioned spinal cords of 4-month-old adult zebrafish show expression of plxnb1a and plxnb1b in the ventricular zone. Dorsal is up and ventral is down. Dotted circle shows the central canal. Scale bar: 50 µm.

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