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Roussange et al., 2026 - Integrative analysis of drug-gene signatures in human pluripotent stem cells reveals prazosin as a novel SQSTM1 regulator for ALS therapeutics
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Figure 3 Prazosin regulates the expression of several genes involved in protein homeostasis and autophagy in fibroblasts from ALS3 patients
(A) Gene set enrichment analysis (GSEA) of transcriptomic data from hES-derived MPCs treated with 10 μM prazosin for 24 h. Data are analyzed using GSEA software to identify statistically significant enrichment in functionally related gene sets.

(B) STRING network analysis of genes regulated by prazosin treatment in hES-derived MPCs (log2 fold change >0.4) based on transcriptomic analysis after 24 h of treatment with 10 μM prazosin.

(C and D) Quantitative real-time PCR analysis of MAP1LC3B, UBC, HSPA5, HSPB8, HSPA1A, HSPA1B, HSPH1, OPTN, and SQSTM1 gene expression was conducted in control fibroblasts and two ALS3 fibroblast lines treated for 24 h with varying doses of prazosin, terazosin, and alfuzosin.

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