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Publication: Perone et al., 2026 - Aip mutation leads to significant alterations in gene expression, altered sensitivity to Ahr ligands, and early lethality in zebrafish
All Figures: Figures for Perone et al., 2026

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FIGURE 3

Behavioral analysis of leflunomide-exposed five dpf larvae from the aip^wh239 line. Exposure condition is presented on the x-axis, and larval movement in mm is presented on the y-axis for LPR total distance. Genotype is denoted by color. Boxplots show the median (horizontal line), mean (circle), interquartile range (box), and 1.5x the interquartile range (whiskers). When exposed to leflunomide, the reduction in movement (hypoactivity) of aip^wh239−/− larvae was significantly greater compared to the other genotypes (p-value ≤0.05, type III ANOVA followed by pairwise t-tests of model-based estimated marginal means adjusted using Benjamini–Hochberg FDR correction).

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