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Fig 5

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ZDB-IMAGE-260606-18

Genes

GCaMP

Publication

Biswas et al., 2026 - Canalization of neural dynamics by δ-protocadherins in the developing zebrafish optic tectum

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Figures for Biswas et al., 2026

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Fig 5 Mutations in pcdh19 or pcdh17 lead to increased phenotypic variability.
A. Cumulative distribution of all pairwise within group r values for wild type (purple), pcdh19^-10bp (blue) pcdh19^Δprom (teal), and pcdh17^-5bp (orange) mutants. (**p < 0.001, Dunn’s test). B. Hypothesized roles of Pcdh19 and Pcdh17 in canalyzing the assembly of visual circuits in the zebrafish optic tectum. In the wild type scenario (left/purple), development is canalized and the outcomes (circuit response to visual stimulation) is restricted, showing a small distribution in outcomes (shaded Gaussian). In the case of protocadherin mutants (right/teal), the developmental landscape is flattened, allowing development to stochastically explore a variety of alternative paths, leading to an increased variation among outcomes (broad shaded distribution).

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