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Fig. 3

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ZDB-IMAGE-260601-3

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Ab15-tuba

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Bertrand et al., 2026 - ⍺TAT1-dependent microtubule acetylation is required for touch sensation in zebrafish but not for cilia-driven morphogenesis

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Fig. 3 ⍺TAT1 is required for neuronal ⍺-tub^K40Ac and normal touch-evoked behavior. (A) Immunofluorescence of zebrafish trunks at 6 dpf stained for ⍺-tub^K40Ac and neurofilament (NF). Scale bar, 50 μm. (B) Still images from touch-evoked escape assays in 6 dpf wild-type siblings and atat1 mutants. t = 0s marks the first tail stimulus; subsequent stimuli in atat1 mutants occurred at 2.0 s and 3.1 s. Scale bar, 1 mm. (C) Immunofluorescence of the Mauthner circuit at 6 dpf. Laterally projecting cranial nerves can be observed flanking Mauthner axons. Scale bar, 20 μm. (D) Quantification of touch responsiveness. A significantly greater proportion of atat1 mutants failed to respond compared with wild-type siblings (n = 16 per group; P = 6.8 × 10⁻⁵, chi-square test). (E) Swim distance following touch-evoked responses. Dots represent individual fish and error bars show standard deviation. P = 0.6 (unpaired t-test). (F) Swim velocity following touch-evoked responses. Dots represent individual fish and error bars show standard deviation. P = 0.55 (unpaired t-test).

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Reprinted from Developmental Biology, 535, Bertrand, S.G., Grimes, D.T., ⍺TAT1-dependent microtubule acetylation is required for touch sensation in zebrafish but not for cilia-driven morphogenesis, 124-132, Copyright (2026) with permission from Elsevier. Full text @ Dev. Biol.