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Fig. 7
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- ZDB-IMAGE-260526-73
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- Cervino et al., 2026 - Sulfatase modifying factors control the timing of zebrafish convergence and extension morphogenesis
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- Figures for Cervino et al., 2026
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Fig. 7
A model for how sulfatase modifying factors regulate the timing of C&E morphogenesis.
Before gastrulation (orange), maternally expressed FGE (sumf1) activates Sulf1, maintaining low levels of 6-O-sulfation (cyan stars) on HSPGs. At the onset of gastrulation (light blue), an inversion in sumf1 and sumf2 transcript abundance (inversion point) increases the antagonistic action of pFGE (sumf2) on FGE (sumf1), thereby reducing Sulf1 activity. This shift leads to increased 6-O-sulfation of HSPGs, generating a permissive environment for C&E morphogenesis via an unknown downstream mechanism.
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Full text @ Nat. Commun.