Fig. 3.
- ID
- ZDB-IMAGE-260522-43
- Antibodies
- Publication
- Dockery et al., 2026 - Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration
- All Figures
- Figures for Dockery et al., 2026
|
Fig. 3. The canonical eif4ea partially compensates for Δeif4e1c phenotypes. (A) Δeif4ea/Δeif4e1c double mutants are at 24% the level of single Δeif4e1c. (B) The Δeif4ea/Δeif4e1c double mutants weigh (purple) 55% less than the Δeif4e1c singles (light green) and 65% less than their wildtype (black) siblings (Mean: wildtype = 0.293g, Δeif4e1c = 0.223g, Δeif4ea/Δeif4e1c = 0.102g, ANOVA p-value <0.0001, N = 95, 66, 16). (C) The double mutants are also shorter (Mean: wildtype = 28.8 mm, Δeif4e1c = 27.5 mm, Δeif4ea/Δeif4e1c = 21.3 mm, ANOVA p-value <0.0001, N = 95, 66, 20). (D, E) double mutant hearts have 66% the number of CMs versus wildtype siblings and 74% the number of CMs as Δeif4e1c siblings (Mean: wildtype = 3122, Δeif4e1c = 2763, Δeif4ea/Δeif4e1c = 2055, ANOVA p-value <0.0001, N = 47, 61, 23). Error bars represent mean ± s.e.m. Scale bar = 100um. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)
Reprinted from Developmental Biology, 534, Dockery, R., Zevallos, M., McNulty, C., Zecchino, T., Ratermann, R., White, R., Kolonay, D., Baskin, K., Goldman, J.A., Genes for 5'mRNA cap binding proteins, eif4ea and eif4eb, have alternative roles during heart regeneration, 50-60, Copyright (2026) with permission from Elsevier. Full text @ Dev. Biol.