Figure 2

Figure 2

ERp44 KO mice display skeletal anomalies by means of CT scan

(A) Representative phenotype of ERp44 KO mouse at 2 months of age; note the exacerbated column curvature.

(B) Skeleton top view of three littermate mice (females) at 2 months of age.

(C) Femoral, tibial, and foot length quantification of the three genotype mice at 11 weeks of age (n = 12, three WT: 1 male and 2 females; five Het: 2 males and 3 females; and four KO mice: 2 males and 2 females). Average values ± SD, Student’s t test with Welch’s correction (∗p < 0.05, ∗∗p < 0.01).

(D) Skeleton lateral view of the same mice in Figure 2B to highlight the typical column curvature of the KO mice.

(E) Skull of 2 month-old mice (females): note open cranial suture of the frontal bones in KO mice (2E, top), which remains partially open at 5 months of age (2E, bottom).