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Fig. 8 Safety assessment of KMU-11361 in zebrafish embryos. A Effect of KMU-11361 on the morphological characteristics of the developing zebrafish embryo. Zebrafish embryos were treated with KMU-11361 at the indicated concentrations for 24 h. Magnified image of the anterior-median-posterior region of zebrafish larvae. B Danio viability, affected fraction and heart beats per minute. heart size, relative size of the eye, relative brain volume in the anterior area, and body length. C A representative fluorescent image of acridine orange-stained zebrafish, demonstrating cellular uptake and distribution (left). The number of apoptotic cells was quantitatively evaluated and compared with those in the vehicle control group (right)