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Fig. 6 Decrease in visual function following post-embryogenesis inhibition of PIKfyve. ERG recordings were performed on 6 dpf zebrafish exposed to 1% DMSO in embryo media (controls) or 500 nM apilimod from 4 to 6 dpf. A) Example ERG traces from one control and one apilimod-treated fish. B) Quantification of a-wave amplitude and implicit time. C) Quantification of b-wave amplitude and implicit time. Each dot on the graphs in B-C represents the average measurement of five recordings from an individual fish. n = 22 control fish, 23 apilimod-treated fish. ∗p < 0.05; ∗∗p < 0.01; ∗∗∗p < 0.001.
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Reprinted from Experimental Eye Research, , Attia, K., Anjum, I., Lingrell, S., Dworkind, C., Benson, M.D., MacDonald, I.M., Hocking, J.C., PIKfyve is an essential component of the endolysosomal pathway within photoreceptors and the retinal pigment epithelium, 110905110905, Copyright (2026) with permission from Elsevier. Full text @ Exp. Eye. Res.