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Fig. 1 The phosphoinositide kinase PIKFYVE is expressed in human ocular tissues. A) The family of phosphoinositide lipids, highlighting the conversions mediated by PIKfyve to generate PI(3,5)P2 and PI(5)P. B) Expression of PIKfyve across select human tissue types based on RNASeq data collated in eyeIntegration v2.12, NEI, NIH. Note the high expression in ocular tissues (red box). (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
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Reprinted from Experimental Eye Research, , Attia, K., Anjum, I., Lingrell, S., Dworkind, C., Benson, M.D., MacDonald, I.M., Hocking, J.C., PIKfyve is an essential component of the endolysosomal pathway within photoreceptors and the retinal pigment epithelium, 110905110905, Copyright (2026) with permission from Elsevier. Full text @ Exp. Eye. Res.