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Publication: Pérez-Escudero et al., 2026 - GPER1 reduces skin inflammation by inhibiting keratinocyte proliferation
All Figures: Figures for Pérez-Escudero et al., 2026

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Fig. 1 Differential expression profile of the genes related to the GPER1 signaling pathway in psoriasis lesional skin compared to healthy or non-lesional skin.

Transcriptomic data obtained from a human psoriasis patient cohort (GSD4602) from the GEO database. a–e Comparison of the expression of several genes implicated in the analyzed pathway between healthy, non-lesional and lesional skin. f, g Analysis of the correlation between GPER1 and the inflammatory markers IL1B and CXCL8, the proliferation marker PCNA, and the differentiation markers FLG and LRC. Each point represents one individual, and the mean ± SEM for each group is also shown. p-values were calculated using one-way ANOVA in Graphs (a–e) and Pearson Correlation test in Graph (f). * p ≤ 0.05, ** p ≤ 0.01, *** p ≤ 0.001, **** p ≤ 0.0001.

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