ZFIN Image: Gao et al., 2026, Figure 1

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Figure Caption

Figure 1

Expression patterns and prognostic relevance of glycosylation-related genes in colorectal cancer. (A) Volcano plot displaying differentially expressed glycosylation-related genes between colorectal cancer and adjacent normal tissues based on TCGA database analysis. Red dots represent upregulated genes, blue dots represent downregulated genes. (B) Heatmap showing hierarchical clustering of differentially expressed glycosylation-related genes in cancer versus normal samples. (C) KEGG pathway enrichment analysis of 24 upregulated glycosylation-related genes. (D) Gene Ontology Biological Process (GO-BP) enrichment analysis of upregulated glycosylation-related genes. (E) KEGG pathway enrichment analysis of 30 downregulated glycosylation-related genes. (F) GO-BP enrichment analysis of downregulated glycosylation-related genes. (G) Oncoprint showing mutation profiles of differentially expressed glycosylation-related genes in colorectal cancer samples. (H–K) Kaplan-Meier survival curves illustrating the association between mutations in UGGT2 (H), GCNT4 (I), PIGZ (J), and GALNT12 (K) genes and overall survival in colorectal cancer patients.

Acknowledgments

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