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Fig. 8 In situ B16F10 cTYR inhibition effects of derivatives 2, 5, and 6. These derivatives were used as test samples, and PTU and KA were used as positive reference substances. KA was tested at 20 μM, whereas 2, 5, 6, and PTU were tested at concentrations of 3.2, 8, and 20 μM. Following 1 h of sample treatment, stimulators (IBMX/α-MSH [200 μM/1 μM]) were administered to B16F10 cells for 72 h. Following l-DOPA (2 mM) treatment for 2 h, melanin-stained cells were photographed to determine in situ cTYR activity. The red arrows indicate cells that are heavily stained with melanin.
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