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Publication: Pistocchi et al., 2026 - Neurotrophic Modulation Restores Motor and Developmental Defects in Zebrafish Models of ints11 Deficiency
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FIGURE 1

ints11 deficient embryos displayed developmental delay and altered motor response. (A–C) Representative images of 4 dpf controls (ctrl) injected with (A) either standard morpholino (std‐MO) or Cas9/tracrRNA and larvae injected with (B) ints11‐sMO and (C) ints11‐sgRNA. Scale bar indicates 300 μm. (D) Touch‐evoked escape response assay performed at 2.5 dpf in controls (n = 40), ints11‐sMO (n = 38) and ints11‐sgRNA (n = 42) embryos. Proportion of embryos with normal TR: Ctrl 39/40; ints11‐sMO: 13/38; ints11‐sgRNA: 12/42. Proportion of embryos with altered TR: Ctrl 1/40; ints11‐sMO: 25/38; ints11‐sgRNA: 30/42. In the histograms the percentage of embryos is expressed as mean ± SEM. Chi‐squared test with Holm–Bonferroni. Refer to Table S3 for raw statistical data. ***p < 0.001. ns not significant.

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