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Figure 6
Graphical summary of the study and tested hypothesis
Initial OKR analysis in larvae revealed ocular motor deficiencies in Panx1a−/− zebrafish, leading to the hypothesis that Panx1a deletion causes structural and/or functional deficits in the eye. Subsequent analyses in adult control and mutant zebrafish confirmed that Panx1a mutation affects emmetropization, induces RGC loss, and produces cataract-like changes/structural defects in the lens, thereby verifying the hypothesis and validating the understanding that Pannexin1a regulates visual system development and ocular integrity in zebrafish.
Acknowledgments
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