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Figure 5
Protein–protein interaction (PPI) network generated with STRING for the 42 increased proteins identified in HaCaT keratinocytes after treatment with PsBU. Functional enrichment analysis (Reactome) highlighted “Transport of Mature mRNA derived from an Intron-Containing Transcript” (HSA-159236) as the top pathway (4 of 73 proteins in the pathway). Central nodes include the nucleoporins NUP85 and NDC1 together with the mRNA-processing/export factors SRSF3 and U2AFBP, underscoring a coordinated role in nucleocytoplasmic export of mature mRNA.
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