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Figure 6
Proposed model. Hypoxia activates Hif-dependent gene expression, leading to metabolic shift towards glycolysis, protein breakdown, gluconeogenesis, and increases in hormonal signaling. An important hypoxia-induced hormonal factor is Stc2a. The increased Stc2a restricts growth and redirects toward critical survival processes by modulation of pappalysin metalloproteinase activity and IGF signaling. Created with
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Full text @ Front Endocrinol (Lausanne)