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Fig 6

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Publication: Flannery et al., 2026 - Impact of maternal compensation on developmental phenotypes in a zebrafish model of severe congenital muscular dystrophy
All Figures: Figures for Flannery et al., 2026

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Fig 6 Differential gene expression analysis in MHets and MZKOs at 10 dpf.

A: Volcano plot showing 810 significantly downregulated DEGs and 149 significantly upregulated DEGs. B: Gene Ontology analysis showing various enriched Biological Processes, Molecular Functions, and Cellular Components among the downregulated DEGs pertaining to lipid and cholesterol metabolism and muscle differentiation and function. D, E: STRING local networks analysis of interactions among the protein products of the downregulated DEGs showing a large, interconnected network of proteins involved in muscle contraction and actin filament capping, as well as fatty acid binding, coagulation, and complement activation (D), and smaller networks of proteins involved in glycolysis and gluconeogenesis, glycerophospholipid metabolism, amino acid metabolism (glycine, serine, threonine), and sterol biosynthesis (E).

Acknowledgments

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